The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Bel'skaia G.N.

Kafedra nevrologii fakul'teta poslevuzovskogo i dopolnitel'nogo professional'nogo obrazovaniia GBOU VPO "Iuzhno-Ural'skiĭ gosudarstvennykh meditsinskiĭ universitet" Minzdrava Rossii, Cheliabinsk

Stepanova S.B.

Kafedra nevrologii fakul'teta poslevuzovskogo i dopolnitel'nogo professional'nogo obrazovaniia GBOU VPO "Iuzhno-Ural'skiĭ gosudarstvennykh meditsinskiĭ universitet" Minzdrava Rossii, Cheliabinsk

Makarova L.D.

South Ural State Medical University, Ministry of Health of Russia, Chelyabinsk, Russia

Sergienko D.A.

Sechenov First Moscow Medical State University, Moscow, Russia

Krilova L.G.

South-Ural State Medical University, Chelyabinsk

Antimonova K.V.

South Ural State Medical University, Ministry of Health of Russia, Chelyabinsk, Russia

Acupuncture in the prevention and treatment of stroke: a review of foreign studies

Authors:

Bel'skaia G.N., Stepanova S.B., Makarova L.D., Sergienko D.A., Krilova L.G., Antimonova K.V.

More about the authors

Journal: Problems of Balneology, Physiotherapy and Exercise Therapy. 2020;97(2): 68‑77

DOI: 10.17116/kurort20209702168

Read: 21067 times

Download PDF (RU)
Contact the author
Table of contents

ACUPUNCTURE IN THE PREVENTION AND TREATMENT OF STROKE: A REVIEW OF FOREIGN STUDIES
ACUPUNCTURE IN THE PREVENTION AND TREATMENT OF STROKE: A REVIEW OF FOREIGN STUDIES

To cite this article:

Bel'skaia GN, Stepanova SB, Makarova LD, Sergienko DA, Krilova LG, Antimonova KV. Acupuncture in the prevention and treatment of stroke: a review of foreign studies. Problems of Balneology, Physiotherapy and Exercise Therapy. 2020;97(2):68‑77. (In Russ.)
https://doi.org/10.17116/kurort20209702168

Подписка 2026 Вопросы курортологии, физиотерапии и лечебной физической культуры (Problems of Balneology, Physiotherapy and Exercise Therapy)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Vali­dation of ballistocardiography data for predicting the sleep effi­ciency in healthy indi­viduals and patients with inso­mnia. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(10):60-66
The influence of hydrokinesitherapy on motor and cardiorespiratory functions in here­ditary myopathy of childhood. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11-2):88-95
Proton pump inhi­bitors: posi­tive and nega­tive properties. On the 45th anni­versary of their discovery. Russian Journal of Preventive Medi­cine. 2024;(11):135-140
Effi­ciency of complex medi­cal reha­bilitation after pulmonary enda­rterectomy. Russian Journal of Cardiology and Cardiovascular Surgery. 2024;(6):629-636
Reflexotherapy as an effe­ctive component of postoperative pain relief. Russian Journal of Pain. 2024;(4):41-45
Stroke: current state of the problem. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):7-18
Evaluation of the effe­ctiveness of the drug Cortexin in combination with the use of the application Apha­sia.No (Afaziyam.Net) in the correction of speech diso­rders in patients with cere­bral infa­rction. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):147-151
Sano­genetic commonality of ultraviolet irra­diation of blood and intravenous ozone therapy. Choice of the opti­mal method of this impact for reha­bilitation of patients after nephrolitholapaxy. Rege­nerative Biotechnologies, Preventive, Digi­tal and Predictive Medi­cine. 2024;(4):95-99
Study of opinions of medi­cal students on medi­cal prevention issues. Russian Journal of Preventive Medi­cine. 2024;(12):69-74
Asse­ssment of risk of deve­loping fractures and sarcopenia and quality of life of patients with chro­nic kidney disease at the outpatient stage. Russian Journal of Preventive Medi­cine. 2024;(12):88-91
Abstract:

Acupuncture has been recommended by the World Health Organization (WHO) as an alternative and complementary method for treating stroke and a way to increase the effectiveness of rehabilitation. The data available in the literature suggest that acupuncture has a beneficial effect on the status of patients with stroke. The mechanism of action of acupuncture for stroke includes the following components: 1) stimulation of neurogenesis and cell proliferation in the CNS; 2) regulation of cerebral blood flow; 3) antiapoptosis; 4) regulation of neurotransmitters; 5) improvement of the neuronal synaptic function, stimulation of long-term potentiation; 6) stimulation of neuroplasticity; and 7) decrease in blood-brain barrier permeability. Acupuncture has been proven to have a positive impact on the restoration of stroke-related dysfunctions, such as motor disorders, spasticity, cognitive impairment, and dysphagia. The most commonly used acupuncture points for the treatment of motor disorders are GV20, GB20, LI4, ST36, SP6, LI11, GB39, and motor scalp area; those for the treatment of cognitive dysfunction are GV20 and EX-HN-1, and those for the treatment of dysphagia are GV20, GV16, and CV23. A review of the literature indicates that studies of the clinical potential of acupuncture in the treatment of complications and the prevention of stroke are insufficient. It is assumed that the international community’s recent interest in acupuncture methods used in the treatment of stroke will lead to the emergence of new studies and publications.

Keywords:

acupuncture
stroke
cerebral ischemia
rehabilitation
prevention
acupuncture
stroke
cerebral ischemia
rehabilitation
prevention

Authors:

Bel'skaia G.N.

Kafedra nevrologii fakul'teta poslevuzovskogo i dopolnitel'nogo professional'nogo obrazovaniia GBOU VPO "Iuzhno-Ural'skiĭ gosudarstvennykh meditsinskiĭ universitet" Minzdrava Rossii, Cheliabinsk

Stepanova S.B.

Kafedra nevrologii fakul'teta poslevuzovskogo i dopolnitel'nogo professional'nogo obrazovaniia GBOU VPO "Iuzhno-Ural'skiĭ gosudarstvennykh meditsinskiĭ universitet" Minzdrava Rossii, Cheliabinsk

Makarova L.D.

South Ural State Medical University, Ministry of Health of Russia, Chelyabinsk, Russia

Sergienko D.A.

Sechenov First Moscow Medical State University, Moscow, Russia

Krilova L.G.

South-Ural State Medical University, Chelyabinsk

Antimonova K.V.

South Ural State Medical University, Ministry of Health of Russia, Chelyabinsk, Russia

Close metadata

References:

  1. World Health Organization. Acupuncture: Review and analysis reports on controlled clinical trials. Geneva: WHO; 2002.
  2. Weng S-W, Chen T-L, Yeh C-C, Liao C-C, Lane H-L, Lin J-G, Shih C-C. An investigation of the use of acupuncture in stroke patients in Taiwan: a national cohort study. BMC Complement Altern Med. 2016;16(1):321-328.
  3. Chavez LM, Huang S-S, MacDonald I, Lin J-G, Lee Y-C, Chen Y-H. Mechanisms of Acupuncture Therapy in Ischemic Stroke Rehabilitation: A Literature Review of Basic Studies. Int J Mol Sci. 2017;18(11):2270-2283.
  4. Kim YR, Kim HN, Ahn SM, Choi YH, Shin HK, Choi BT. Electroacupuncture promotes post-stroke functional recovery via enhancing endogenous neurogenesis in mouse focal cerebral ischemia. PLoS ONE. 2014;9(2):e90000.
  5. Hong J, Wu G, Zou Y, Tao J, Chen L. Electroacupuncture promotes neurological functional recovery via the retinoic acid signaling pathway in rats following cerebral ischemia-reperfusion injury. Int J Mol Med. 2013;31:225-231.
  6. Chen B, Tao J, Lin Y, Lin R, Liu W, Chen L. Electro-acupuncture exerts beneficial effects against cerebral ischemia and promotes the proliferation of neural progenitor cells in the cortical peri-infarct area through the Wnt/β-catenin signaling pathway. Int J Mol Med. 2015;36:1215-1222.
  7. Lu T, Luo Y, Sun H, Qin W, Li Y. Electroacupuncture improves behavioral recovery and increases SCF/c-kit expression in a rat model of focal cerebral ischemia/reperfusion. Neurol Sci. 2013;34:487-495.
  8. Huang J, Ye X, You Y, Liu W, Gao Y, Yang S, Peng J, Hong Z, Tao J, Chen L. Electroacupuncture promotes neural cell proliferation in vivo through activation of the ERK1/2 signaling pathway. Int J Mol Med. 2014;33:1547-1553.
  9. Xie G, Yang S, Chen A, Lan L, Lin Z, Gao Y, Huang J, Lin J, Peng J, Tao J, Chen L. Electroacupuncture at Quchi and Zusanli treats cerebral ischemia-reperfusion injury through activation of ERK signaling. Exp Ther Med. 2013;5:1593-1597.
  10. Tao J, Zheng Y, Liu W, Yang S, Huang J, Xue X, Shang G, Wang X, Lin R, Chen L. Electro-acupuncture at LI11 and ST36 acupoints exerts neuroprotective effects via reactive astrocyte proliferation after ischemia and reperfusion injury in rats. Brain Res Bull. 2016;120:14-24.
  11. Kim JH, Choi KH, Jang YJ, Bae SS, Shin BC, Choi BT, Shin HK. Electroacupuncture acutely improves cerebral blood flow and attenuates moderate ischemic injury via an endothelial mechanism in mice. PLoS ONE. 2013;8:e56736.
  12. Li J, He J, Du Y1, Cui J, Ma Y, Zhang X. Electroacupuncture improves cerebral blood flow and attenuates moderate ischemic injury via Angiotensin II its receptors-mediated mechanism in rats. BMC Complement Altern Med. 2014;14:441.
  13. Kim YR, Kim HN, Jang JY, Park C, Lee JH, Shin HK, Choi YH, Choi BT. Effects of electroacupuncture on apoptotic pathways in a rat model of focal cerebral ischemia. Int J Mol Med. 2013;32:1303-1310.
  14. Xue X, You Y, Tao J, Ye X, Huang J, Yang S, Lin Z, Hong Z, Peng J, Chen L. Electro-acupuncture at points of Zusanli and Quchi exerts anti-apoptotic effect through the modulation of PI3K/Akt signaling pathway. Neurosci Lett. 2014;558:14-19.
  15. Cheng CY, Lin JG, Su SY, Tang NY, Kao ST, Hsieh CL. Electroacupuncture-like stimulation at Baihui and Dazhui acupoints exerts neuroprotective effects through activation of the brain-derived neurotrophic factor-mediated MEK1/2/ERK1/2/p90RSK/bad signaling pathway in mild transient focal cerebral ischemia in rats. BMC Complement Altern Med. 2014;14:92.
  16. Wu C, Wang J, Li C, Zhou G, Xu X, Zhang X, Lan X. Effect of electroacupuncture on cell apoptosis and ERK signal pathway in the hippocampus of adult rats with cerebral ischemia-reperfusion. Evid Based Complement Altern Med. 2015;414965.
  17. Cheng CY, Lin JG, Tang NY, Kao ST, Hsieh CL. Electroacupuncture at different frequencies (5 and 25 Hz) ameliorates cerebral ischemia-reperfusion injury in rats: Possible involvement of p38 MAPK-mediated anti-apoptotic signaling pathways. BMC Complement Altern Med. 2015;15:241.
  18. Cheng CY, Lin JG, Tang NY, Kao ST, Hsieh CL. Electroacupuncture-like stimulation at the Baihui (GV20) and Dazhui (GV14) acupoints protects rats against subacute-phase cerebral ischemia-reperfusion injuries by reducing S100B-mediated neurotoxicity. PLoS ONE. 2014;9(3):e91426.
  19. Feng X, Yang S, Liu J, Huang J, Peng J, Lin J, Tao J, Chen L. Electroacupuncture ameliorates cognitive impairment through inhibition of NF-κB-mediated neuronal cell apoptosis in cerebral ischemia-reperfusion injured rats. Mol Med Rep. 2013;7:1516-1522.
  20. Chen M, Sun HY, Hu P, et al. Activation of BKca channels mediates hippocampal neuronal death after reoxygenation and reperfusion. Mol Neurobiol. 2013;48:794-807.
  21. Wang Y, Shen Y, Lin HP, Li Z, Chen YY, Wang S. Large-conductance Ca2+-activated K+ channel involvement in suppression of cerebral ischemia/reperfusion injury after electroacupuncture at Shuigou(GV26) acupoint in rats. Neural Regen Res. 2016;11(6):957-962.
  22. Xu Q, Yang JW, Cao Y, Zhang LW, Zeng XH, Li F, Du SQ, Wang LP, Liu CZ. Acupuncture improves locomotor function by enhancing GABA receptor expression in transient focal cerebral ischemia rats. Neurosci Lett. 2015;588:88-94.
  23. Ng GY-Q, Lim Y-A, Sobey CG, Dheen T, Fann DY-W, Arumugam TV. Epigenetic regulation of inflammation in stroke. Ther Adv Neurol Disord. 2018;11:1756286418771815.
  24. Xu H, Sun H, Chen SH, Zhang YM, Piao YL, Gao Y. Effects of acupuncture at Baihui (DU20) and Zusanli (ST36) on the expression of heat shock protein 70 and tumor necrosis factor α in the peripheral serum of cerebral ischemia-reperfusion-injured rats. Chin J Integr Med. 2014;20:369-374.
  25. Lan L, Tao J, Chen A, Xie G, Huang J, Lin J, Peng J, Chen L. Electroacupuncture exerts anti-inflammatory effects in cerebral ischemia-reperfusion injured rats via suppression of the TLR4/NF-κB pathway. Int J Mol Med. 2013;31:75-80.
  26. Shi P, Sun LL, Lee YS, Tu Y. Electroacupuncture regulates the stress-injury-repair chain of events after cerebral ischemia/reperfusion injury. Neural Regen Res. 2017;12(6):925-930.
  27. Shi GX, Wang XR, Yan CQ, He T, Yang JW, Zeng XH, Xu Q, Zhu W, Du SQ, Liu CZ. Acupuncture elicits neuroprotective effect by inhibiting NAPDH oxidase-mediated reactive oxygen species production in cerebral ischaemia. Sci Rep. 2015;5:17981.
  28. Jittiwat J. Laser Acupuncture at GV20 Improves Brain Damage and Oxidative Stress in Animal Model of Focal Ischemic Stroke. J Acupunct Meridian Stud. 2017;10(5):324-330.
  29. Mehan S, Parveen S, Kaur G, Kukkar U, Dudi R, Rajput M, Kalra S. Targeting Phytochemical Driver in AC/cAMP/PKA/CREB Activation: The Next Frontier for Alleviating Huntington’s Type Neurodegenerative Disorders in 3-NP Animal Model: A Complete Review. EC Neurology. 2017;6(3):77-131.
  30. Li QQ, Shi GX, Yang JW, Li ZX, Zhang ZH, He T, Wang J, Liu LY, Liu CZ. Hippocampal cAMP/PKA/CREB is required for neuroprotective effect of acupuncture. Physiol Behav. 2015;139:482-490.
  31. Liu W, Wu J, Huang J, Zhuo P, Lin Y, Wang L, Lin R, Chen L, Tao J. Electroacupuncture Regulates Hippocampal Synaptic Plasticity via miR-134-Mediated LIMK1 Function in Rats with Ischemic Stroke. Neural Plast. 2017;9545646.
  32. Zhang Y, Lin R, Tao J, Wu Y, Chen B, Yu K, Chen J, Li X, Chen L-D. Electroacupuncture improves cognitive ability following cerebral ischemia reperfusion injury via CaM-CaMKIV-CREB signaling in the rat hippocampus. Exp Ther Med. 2016;12(2):777-782.
  33. Zhang Y, Li K-S, Ning Y-Z, Fu C-H, Liu H-W, Han X, Cui F-Y, Ren Y, Zou Y-H. Altered structural and functional connectivity between the bilateral primary motor cortex in unilateral subcortical stroke: a multimodal magnetic resonance imaging study. Medicine (Baltimore). 2016;95:e4534.
  34. Li Y, Wang D, Zhang H, Wang Y, Wu P, Zhang H, Yang Y, Huang W. Changes of brain connectivity in the primary motor cortex after subcortical stroke: a multimodal magnetic resonance imaging study. Medicine (Baltimore). 2016;95:e2579.
  35. Fu CH, Li KS, Ning YZ, Tan ZJ, Zhang Y, Liu HW, Han X, Zou YH. Altered effective connectivity of resting state networks by acupuncture stimulation in stroke patients with left hemiplegia. A multivariate granger analysis Medicine (Baltimore). 2017;96(47):e8897.
  36. Fu S, Gu Y, Jiang JQ, Chen X, Xu M, Chen X, Shen J. Calycosin-7-O-β-D-glucoside regulates nitric oxide /caveolin-1/matrix metalloproteinases pathway and protects blood-brain barrier integrity in experimental cerebral ischemia-reperfusion injury. Journal of Ethnopharmacology. 2014;155(1):692-701.
  37. Li HQ, Li Y, Chen ZX, Zhang XG, Zheng XW, Yang WT, Chen S, Zheng GQ. Electroacupuncture Exerts Neuroprotection through Caveolin-1 Mediated Molecular Pathway in Intracerebral Hemorrhage of Rats. Neural Plast. 2016;7308261.
  38. You YN, Cho MR, Kim JH, Park JH, Park GC, Song MY, Choi JB, Han JY. Assessing the quality of reports about randomized controlled trials of scalp acupuncture combined with another treatment for stroke. BMC Complement Altern Med. 2017;17(1):452.
  39. Xu M, Li D, Zhang S. Acupuncture for acute stroke. Cochrane Database Syst Rev. 2018. [Epub ahead of print].
  40. Lim SM, Yoo J, Lee E, Kim HJ, Shin S, Han G, Ahn HS. Acupuncture for Spasticity after Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Evid Based Complement Alternat Med. 2015;870398.
  41. Li Y, Wang Y, Zhang H, Wu P, Huang W. The effect of acupuncture on the motor function and white matter microstructure in ischemic stroke patients. Evid Based Complement Alternat Med. 2015;10.
  42. Jin Y, Jin X, Chen Y, Zhu J. Acupuncture and constraint-induced movement therapy for a patient with chronic stroke. One-year follow-up case report. Medicine (Baltimore). 2017;96(46):e8737.
  43. Du XZ, Bao CL, Dong GR, Yang XM. Immediate effects of scalp acupuncture with twirling reinforcing manipulation on hemiplegia following acute ischemic stroke: a hidden association study. Neural Regen Res. 2016;11(5):758-764.
  44. Chen L, Fang J, Ma R, Gu X, Chen L, Li J, Xu S. Additional effects of acupuncture on early comprehensive rehabilitation in patients with mild to moderate acute ischemic stroke: a multicenter randomized controlled trial. BMC Complement Altern Med. 2016;16:226.
  45. Li Y, Wang Y, Liao C, Huang W, Wu P. Longitudinal Brain Functional Connectivity Changes of the Cortical Motor-Related Network in Subcortical Stroke Patients with Acupuncture Treatment. Neural Plast. 2017;5816263.
  46. Ye Q, Xie Y, Shi J, Xu Z, Ou A, Xu N. Systematic Review on Acupuncture for Treatment of Dysphagia after Stroke. Evid Based Complement Alternat Med. 2017;6421852.
  47. Li LX, Deng K, Qu Y. Acupuncture Treatment for Post-Stroke Dysphagia: An Update Meta-Analysis of Randomized Controlled Trials. Chin J Integr Med. 2018. [Epub ahead of print].
  48. Chen D, Guo H. Therapeutic effects of acupuncture combined with rehabilitation training on dysphagia in post-stroke pseudobulbar palsy. Zhongguo Zhen Jiu. 2018;38(4):364-368.
  49. Liu F, Li ZM, Jiang YJ, Chen LD. A meta-analysis of acupuncture use in the treatment of cognitive impairment after stroke. J Altern Complement Med. 2014;20(7):535-544.
  50. Wang S, Yang H, Zhang J, Zhang B, Liu T, Gan L, Zheng J. Efficacy and safety assessment of acupuncture and nimodipine to treat mild cognitive impairment after cerebral infarction: a randomized controlled trial. BMC Complement Altern Med. 2016;16:361.
  51. Weng SW, Liao CC, Yeh CC, Chen TL, Lane HL, Lin JG, Shih CC. Risk of epilepsy in stroke patients receiving acupuncture treatment: a nationwide retrospective matched-cohort study. BMJ Open. 2016;6(7):e010539.
  52. Chuang S-F, Shih C-C, Yeh C-C, Lane H-L, Tsai C-C, Chen T-L, Lin J-G, Tainsong C, Liao C-C. Decreased risk of acute myocardial infarction in stroke patients receiving acupuncture treatment: a nationwide matched retrospective cohort study. BMC Complement Altern Med. 2015;15:318.
  53. Tseng SP, Hsu YC, Chiu CJ, Wu ST. A Population-Based Cohort Study on the Ability of Acupuncture to Reduce Post-Stroke Depression. Medicines (Basel). 2017;4(1):16.
  54. Ferre A, Ribó M, Rodríguez-Luna D, Romero O, Sampol G, Molina CA, Álvarez-Sabin J. Strokes and their relationship with sleep and sleep disorders. Neurologia. 2013;28(2):103-118.
  55. Glozier N, Moullaali TJ, Sivertsen B, Kim D, Mead G, Jan S, Li Q, Hackett ML. The Course and Impact of Poststroke Insomnia in Stroke Survivors Aged 18 to 65 Years: Results from the Psychosocial Outcomes In StrokE (POISE) Study. Cerebrovasc Dis Extra. 2017;7(1):9-20.
  56. McDermott M, Brown DL, Chervin RD. Sleep disorders and the risk of stroke. Expert Rev Neurother. 2018;18(7):523-531.
  57. Lee SH, Lim SM. Acupuncture for insomnia after stroke: a systematic review and meta-analysis. BMC Complement Altern Med. 2016;16:228.
  58. Zhao KC. Acupuncture for the Treatment of Insomnia. Int Rev Neurobiol. 2013;111:217-234.
  59. Shih CC, Liao CC, Sun MF, Su YC, Wen CP, Morisky DE, Sung FC, Hsu C-Y, Lin JG. A Retrospective Cohort Study Comparing Stroke Recurrence Rate in Ischemic Stroke Patients With and Without Acupuncture Treatment. Medicine (Baltimore). 2015;94(39):e1572.
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.