The role of interval hypoxytherapy and enteral oxygen therapy in the rehabilitation of the patients presenting with chronic obstructive pulmonary disease

Borukaeva I.Kh.; Abazova Z.Kh.; Ivanov A.B.; Shkhagumov K.Yu.

doi:https://doi.org/10.17116/kurort20199602127

Borukaeva I.Kh.

FGBOU VPO "Kabardino-Balkarskiĭ gosudarstvennyĭ universitet im. Kh.M. Berbekova", Nal'chik;
FGBU "Rossiĭskiĭ nauchnyĭ tsentr meditsinskoĭ reabilitatsii i kurortologii" Minzdravsotsrazvitiia Rossii, Moskva

Abazova Z.Kh.

Kabardino-Balkarskij gosudarstvennyj universitet im. H.M. Berbekova, meditsinskij fakul'tet, ul. Chernyshevskogo, 173, Nal'chik, Rossijskaja Federatsija, 360004

Ivanov A.B.

Kabardino-Balkarskij gosudarstvennyj universitet im. H.M. Berbekova, meditsinskij fakul'tet, ul. Chernyshevskogo, 173, Nal'chik, Rossijskaja Federatsija, 360004

Shkhagumov K.Yu.

Kh.M. Berbekov Kabardino-Balkarian State University, Nalchik, Russia

The role of interval hypoxytherapy and enteral oxygen therapy in the rehabilitation of the patients presenting with chronic obstructive pulmonary disease

Authors:

Borukaeva I.Kh., Abazova Z.Kh., Ivanov A.B., Shkhagumov K.Yu.

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Journal: Problems of Balneology, Physiotherapy and Exercise Therapy. 2019;96(2): 27‑32

DOI: 10.17116/kurort20199602127

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To cite this article:

Borukaeva IKh, Abazova ZKh, Ivanov AB, Shkhagumov KYu. The role of interval hypoxytherapy and enteral oxygen therapy in the rehabilitation of the patients presenting with chronic obstructive pulmonary disease. Problems of Balneology, Physiotherapy and Exercise Therapy. 2019;96(2):27‑32. (In Russ.)
https://doi.org/10.17116/kurort20199602127

Подписка 2026 Вопросы курортологии, физиотерапии и лечебной физической культуры (Problems of Balneology, Physiotherapy and Exercise Therapy)

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Abstract:

Background. The efficiency of the application of normobaric interval hypoxic therapy and enteral oxygen therapy for the treatment of the patients suffering from chronic obstructive pulmonary disease remains to be confirmed. Aims. The objective of the present study was the identification of the pathophysiological mechanisms responsible for the efficiency of normobaric interval hypoxic therapy and enteral oxygen therapy in the patients presenting with a chronic obstructive pulmonary disease. Material and methods. A total of 230 patients at the age from 45 to 60 years were examined. All of them presented with chronic obstructive pulmonary disease (COPD). 150 patients were given a course of normobaric interval hypoxic therapy and enteral oxygen therapy while the remaining 80 ones constituted the control group. Results. It was shown that the combined application of normobaric interval hypoxic therapy and enteral oxygen therapy provided an effective tool for the correction of the health status in the patients with chronic obstructive pulmonary disease. This method allowed to improve arterial blood supply with oxygen, increase the blood hemoglobin level and its oxygen capacity, augment oxygen tension and content in the arterial blood. The combination of the intake of oxygen cocktails and hypoxic therapy resulted in the improvement of metabolic processes in the lungs manifested as the alteration in the characteristics of the condensate of the exhaled air. The decrease in the content of malondialdehyde gave evidence of the reduction of lipid peroxidation while the enhanced activities of glutathione peroxidase and superoxide dismutase in blood confirmed the activation of the antioxidant system. The improved oxygen supply at all stages of its mass transfer along with the resulting improvement of oxygen utilization by the tissues was responsible for the reduction of hypoxia in the bronchial tree and lung tissue. Conclusions. The present study confirmed the high effectiveness of the combined application of normobaric interval hypoxic therapy and enteral oxygen therapy for the rehabilitation of the patients presenting with chronic obstructive pulmonary disease.

Keywords:

chronic obstructive pulmonary disease; hypoxia; oxygen therapy; lipid peroxidation; antioxidants

Authors:

Borukaeva I.Kh.

Abazova Z.Kh.

Kabardino-Balkarskij gosudarstvennyj universitet im. H.M. Berbekova, meditsinskij fakul'tet, ul. Chernyshevskogo, 173, Nal'chik, Rossijskaja Federatsija, 360004

Ivanov A.B.

Kabardino-Balkarskij gosudarstvennyj universitet im. H.M. Berbekova, meditsinskij fakul'tet, ul. Chernyshevskogo, 173, Nal'chik, Rossijskaja Federatsija, 360004

Shkhagumov K.Yu.

Kh.M. Berbekov Kabardino-Balkarian State University, Nalchik, Russia

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References:

Ivanova EV, Bilichenko TN, Chuchalin AG. Morbidity and mortality from respiratory diseases in employable population of Russia in 2010—2012. Pul’monologiya. 2015;25:3:291-297. (In Russ.)
Meshcheryakova NN, Belevskiy AS. Depression in patients with chronic obstructive pulmonary disease and effects of pulmonary rehabilitation. Pul’monologiya. 2015;25:1:64-67. (In Russ.)
Hronicheskaya obstruktivnaya bolezn’ legkih. Prakticheskoe rukovodstvo dlya vrachei. Federal’naya programma. Ed by Chuchalin AG. Izd. 2-e, pererab. i dop. M. 2004. (In Russ.) http://www.pulmonology.ru/about/gard/COPD_federal_program_2004.pdf
Vasilenko AM, Agasarov LG, Sharipova MM. The physical methods for the prevention and management of weather-dependent pathological reactions (a literature review). Problems of balneology, physiotherapy, and exercise therapy. 2016;93:5:58-65. (In Russ.) https://doi.org/10.17116/kurort2016558-65
Vasilenko AM, Radzievskij SA, Agasarov LG, Bugaev SA. Reflexotherapy in the context of rehabilitative medicine. Problems of balneology, physiotherapy, and exercise therapy. 2013;90:1:32-38. (In Russ.)
Airapetova NS, Eremushkin MA, Antonovich IV, Kuznetsov OF, Samorukov AE, Budylin SP, Tarasova LYu, Derevnina NA. The rehabilitative treatment of the patients presenting with chronic obstructive pulmonary disease including the application of the manual handling methods. Problems of balneology, physiotherapy, and exercise therapy. 2017;94:3:11-16. (In Russ.) https://doi.org/10.17116/kurort201794311-16
Ivanova DA, Khan MA., Lyan NA, Mikitchenko NA. The application of the pulsed low-frequency electrostatic field for the combined treatment of the children presenting with bronchial asthma. Problems of balneology, physiotherapy, and exercise therapy. 2015;92:4:30-35. (In Russ.) https://doi.org/10.17116/kurort2015430-35
Konova OM, Namazova-Baranova LS, Dmitrienko EG, Davydova IV. The role of enteral oxygen-therapy in the correction of functional disturbances in the vegetative nervous system of the children presenting with chronic diseases of the respiratory organs. Problems of balneology, physiotherapy, and exercise therapy. 2014;91:6:16-21. (In Russ.)
Nikitin AV, Marks SI. The application of chromo- and laserotherapy for the treatment of the patients presenting with chronic obstructive pulmonary disease and concomitant arterial hypertension. Problems of balneology, physiotherapy, and exercise therapy. 2014;91:4:3-6. (In Russ.)
Han MA, Badalov NG, Uyanaeva AI, Lyan NA, Chukina IM, Mikitchenko NA. The comparative characteristic of the effectiveness of sanatorium-resort treatment of children with bronchial asthma in the conditions of the resort Gelendzhik. Problems of balneology, physiotherapy, and exercise therapy. 2017;94(2):152-153. (In Russ.)
Abazova ZH, Ivanov AB, Borukaeva IH, Kumykov VK. The application of normobaric hypoxytherapy for the subclinical hypothyroidism. Problems of balneology, physiotherapy, and exercise therapy. 2015;92:2:28-31. (In Russ.) https://doi.org/10.17116/kurort2015228-31
Abazova ZH, Kumykov VK, Bajsiev AH-M, Efendieva MK. Hypoxytherapy in combined treatment of autoimmune thyropathy. Problems of balneology, physiotherapy, and exercise therapy. 2006;3:11-13. (In Russ.)
Dolgih VV, Rychkova LV, Vlasenko AV. Efficiency of normobaric hypoxytherapy in the combined rehabilitation of children and adolescents with arterial hypertension. Problems of balneology, physiotherapy, and exercise therapy. 2009;86:6:11-14. (In Russ.)
Kolchinskaya AZ, Abazova ZH, Kumykov VK, Hatsukov BH. The main milestones of development of science about a hypoxia. Problemy sotsial’noy gigieny, zdravookhraneniya i istorii meditsiny. 2002;2:52-54. (In Russ.)
Kolchinskaja AZ, Tsyganova TN, Ostapenko LA. Normobaricheskaya interval’naya gipoksicheskaya trenirovka v meditsine i sporte. M.: Meditsina; 2003. (In Russ.)
Borukaeva IH, Ivanov AB, Abazova ZH. Mehanizmy effektivnosti adaptatsii k gipoksii u bol’nyh hronicheskimi obstruktivnymi boleznyami legkih. (Conference proceedings) Mezhdunarodnaya nauchnaya konferentsiya, posvyashhennaya 75-letiyu AGU. Maikop. 2015. (In Russ.) http://www.adygnet.ru/node/6386
Edil’bieva AS, Frolkov VK, Nagornev SN, Hudov VV. Dynamics of lipoperoxidation processes state in patients with chronic obstructive lung disease at course application of hypoxic training combined with physical load. Kurortnaya meditsina. 2017;2:106-112. (In Russ.).
Sirotinin NN. Vliyanie na organizm peroral’nogo vvedeniya kislorodnoi peny. (Conference proceedings) Respublikanskaya nauchno-prakticheskaya konferentsiya «Enteral’naya oksigenoterapiya». Kiev. 1968. (In Russ.) http://www.informio.ru/publications/id1375/Vlijanie-kislorodnyh-kokteilei-na-organizm-cheloveka
Antonyuk MV, Gvozdenko TA. Medical rehabilitation of patients with pulmonary diseases: modern view on the problem and perspectives of treatment in the Far East. Byulleten’ fiziologii i patologii dyhaniya. 2016;59:87-97. (In Russ.)
Uryasev OM, Isaeva IA, Baylovskiy YuYu. Non-medical treatment in patients with bronchial asthma with concomitant cardio-vescular diseases. Zemskii vrach. 2017;1:12-16. (In Russ.)