We undertook the comprehensive examination and treatment with the interval hypoxic training and enteral oxygen therapy of 285 patients presenting with mild and moderately severe bronchial asthma. The study has demonstrated the improvement of oxygen supply to various organs at all stages of its mass transfer and the enhanced oxygen consumption by the tissue. These effects promoted normalization of the function of the respiratory system, characteristics of the exhaled air condensate, the state of the pro-oxidant and anti-oxidant systems. The data obtained confirm the high efficacy of application of the combined therapeutic modality including interval hypoxic training and enteral oxygen therapy for the treatment of patients with bronchial asthma. Its clinical effect was achieved in the first place due to the activation of the mechanisms of adaptation to interval hypoxia, such as the improvement of the alveolar ventilation process during breathing, and blood circulation patterns. The beneficial influence on the mechanisms of adaptation to hypoxia and oxygen leads to the significant improvement of blood respiration function, enhanced saturation and oxygen tension in the arterial blood, arteriovenous oxygen difference, the rate and intensity of oxygen consumption in the tissues.