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Kryukov A.I.

Pirogov Russian National Research Medical University;
Sverzhevsky Research Clinical Institute of Otorhinolaryngology

Gurov A.V.

N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia;
Sverzhevsky Research Institute of Clinical Otorhinolaryngology

Cherkasov D.S.

Pirogov Russian National Research Medical University

Magomedov M.A.

Pirogov Russian National Research Medical University 1, Ostrovityanov St.;
Pirogov City Clinical Hospital No. 1

Lapchenko A.A.

Pirogov City Clinical Hospital No. 1

Raji Y.A.

Pirogov Russian National Research Medical University 1, Ostrovityanov St.

Yarushina E.O.

Pirogov City Clinical Hospital No. 1

Clinical efficiency of polyvalent piobacteriophage in the complex treatment of nosocomial sinusitis

Authors:

Kryukov A.I., Gurov A.V., Cherkasov D.S., Magomedov M.A., Lapchenko A.A., Raji Y.A., Yarushina E.O.

More about the authors

Journal: Russian Bulletin of Otorhinolaryngology. 2025;90(4): 33‑38

DOI: 10.17116/otorino20259004133

Read: 536 times

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Table of contents

CLINICAL EFFICIENCY OF POLYVALENT PIOBACTERIOPHAGE IN THE COMPLEX TREATMENT OF NOSOCOMIAL SINUSITIS
CLINICAL EFFICIENCY OF POLYVALENT PIOBACTERIOPHAGE IN THE COMPLEX TREATMENT OF NOSOCOMIAL SINUSITIS

To cite this article:

Kryukov AI, Gurov AV, Cherkasov DS, Magomedov MA, Lapchenko AA, Raji YA, Yarushina EO. Clinical efficiency of polyvalent piobacteriophage in the complex treatment of nosocomial sinusitis. Russian Bulletin of Otorhinolaryngology. 2025;90(4):33‑38. (In Russ.)
https://doi.org/10.17116/otorino20259004133

Подписка 2026 Вестник оториноларингологии (Russian Bulletin of Otorhinolaryngology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The article presents the results of the study of polyvalent pyobacteriophage in the complex therapy of nosocomial sinusitis in 30 patients of intensive care units of a multidisciplinary hospital in Moscow. The etiologic factors of nosocomial sinusitis manifestation were the following microorganisms: Klebsiella pneumoniae, Acinetobacter baumannii, Staphylococcus aureus, Acinetobacter nosocomialis, Pseudomonas aeruginosa, Proteus mirabilis, Enterobacter aerogenes. According to the results of the study it was revealed that at the empirical phage therapy the regression of the main clinical symptomatology was achieved in 90% of patients. The average number of days of this therapy before registration of clinical sanation of the maxillary sinus was 4±1.9. Microbiological sanitation of the maxillary sinuses was achieved in 46.7% of cases.

Keywords:

bacteriophages
phage therapy
sinusitis
nosocomial infections
nosocomial strains of microorganisms

Authors:

Kryukov A.I.

Pirogov Russian National Research Medical University;
Sverzhevsky Research Clinical Institute of Otorhinolaryngology

Gurov A.V.

N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia;
Sverzhevsky Research Institute of Clinical Otorhinolaryngology

Cherkasov D.S.

Pirogov Russian National Research Medical University

Magomedov M.A.

Pirogov Russian National Research Medical University 1, Ostrovityanov St.;
Pirogov City Clinical Hospital No. 1

Lapchenko A.A.

Pirogov City Clinical Hospital No. 1

Raji Y.A.

Pirogov Russian National Research Medical University 1, Ostrovityanov St.

Yarushina E.O.

Pirogov City Clinical Hospital No. 1

Received:

13.02.2025

Accepted:

08.04.2025

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References:

  1. Letarov AV. History of early bacteriophage research and the birth of basic virology concepts (review). Biokhimia. 2020;(9):1189-1212. (In Russ.).
  2. Gould K. Antibiotics: from prehistory to the present day. Journal of Antimicrobial Chemotherapy. 2016;71(3):572-575.  https://doi.org/10.1093/jac/dkv484
  3. Perepanova TS, Kazachenko AV, Hazan PL, Malova YuA. Therapeutic applications of bacteriophages: back to the future. Klinicheskaya mikrobiologiya i antimikrobnaya khimioterapiya. 2021;(1):55-64. (In Russ.).
  4. Sannathimmappa MB, Nambiar V, Aravindakshan R. Antibiotics at the crossroads — Do we have any therapeutic alternatives to control the emergence and spread of antimicrobial resistance? Journal of Education and Health Promotion. 2021;10:438.  https://doi.org/10.4103/jehp.jehp_557_21
  5. Lemiech-Mirowska E, Kiersnowska ZM, Michałkiewicz M, Depta A, Marczak M. Nosocomial infections as one of the most important problems of healthcare system. Annals of Agricultural and Environmental Medicine: AAEM. 2021;28(3):361-366.  https://doi.org/10.26444/aaem/122629
  6. Gordillo Altamirano FL, Barr JJ. Phage Therapy in the Postantibiotic Era. Clinical Microbiology Reviews. 2019;32(2):e00066-18.  https://doi.org/10.1128/CMR.00066-18
  7. Kryukov AI, Gurov AV, Izotova GN, Lapenko EG. Results of the observational (non-interventional) research ‘Analysis of therapeutic efficiency of the polyvalent Piobacteriophag (Secstaphag) in the treatment of acute sinusitis’. Russian Bulletin of Otorhinolaryngology. 2019;84(5):55-60. (In Russ.). https://doi.org/10.17116/otorino20198405155
  8. Lazareva LA, Skibitskii VV, Dorofeeva YuI, Ashuba IL. The experience of application of gel preparations containing bacteriophages in the complex therapy of nosocomial rhinosinusitises. Rossijskaya otorinolaringologiya. 2017;5(90):119-127. (In Russ.).
  9. Krukov AI, Gurov AV, Izotova GN, Lapenko EG. Bacteriophages therapy in otorhinolaryngology. History and contemporaneity. Russian Bulletin of Otorhinolaryngology. 2019;84(1):84-89. (In Russ.). https://doi.org/10.17116/otorino20198401184
  10. Mevio E, Benazzo M, Quaglieri S, Mencherini S. Sinus infection in intensive care patients. Rhinology. 1996;34(4):232-236. 
  11. Bert F, Lambert-Zechovsky N. Sinusitis in mechanically ventilated patients and its role in the pathogenesis of nosocomial pneumonia. European Journal of Clinical Microbiology and Infectious Diseases. 1996;15(7):533-544.  https://doi.org/10.1007/BF01709360
  12. Tagliaferri TL, Jansen M, Horz HP. Fighting Pathogenic Bacteria on Two Fronts: Phages and Antibiotics as Combined Strategy. Frontiers in Cellular and Infection Microbiology. 2019;9:22.  https://doi.org/10.3389/fcimb.2019.00022
  13. Schmerer M, Molineux IJ, Bull JJ. Synergy as a rationale for phage therapy using phage cocktails. PeerJ. 2014;2:e590. https://doi.org/10.7717/peerj.590
  14. Ilyina TS, Romanova YuM. Bacterial biofilms: their role in chronical infection processes and the means to combat them. Molekulyarnaya genetika, mikrobiologiya i virusologiya. 2021;39(2):14-24. (In Russ.). https://doi.org/10.17116/molgen20213902114
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