Effective intranasal GCS application strategy of mono and combines forms in treating patients, suffering from allergic rhinitis. Evidence-based medicine to help a practitioner

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OBJECTIVE

To summarize effective intranasal glucocorticosteroids (GCS) application strategies in treatment of patients, suffering from allergic rhinitis (depending on disease type), based on actual research results. Current study determines the place of fixed intranasal GCS and topic antihistamine medication combination, specifically azelastine and mometasone furoate, as a first line of choice therapy in treatment of patients, suffering from allergic rhinitis. Effective application of stage therapy allows us establish control over allergic inflammation and significantly decrease pharmaceutical load in cases of patients, suffering from allergic rhinitis.

Keywords:

allergic rhinitis

allergic inflammation

azelastine

mometasone furoate

Authors:

Tataurschikova N.S.

RUDN University

Berezhanskiy P.V.

Peoples’ Friendship University of Russia

Rusanova A.S.

Peoples’ Friendship University of Russia

Received:

23.11.2021

Accepted:

10.12.2021

List of references:

Bousquet J, Schünemann HJ, Togias A, Bachert C, Erhola M, Hellings PW, Klimek L, Pfaar O, Wallace D, Ansotegui I, Agache I, Bedbrook A, Bergmann KC, Bewick M, Bonniaud P, Bosnic-Anticevich S, Bossé I, Bouchard J, Boulet LP, Brozek J, Brusselle G, Calderon MA, Canonica WG, Caraballo L, Cardona V, Casale T, Cecchi L, Chu DK, Costa EM, Cruz AA, Czarlewski W, D’Amato G, Devillier P, Dykewicz M, Ebisawa M, Fauquert JL, Fokkens WJ, Fonseca JA, Fontaine JF, Gemicioglu B, van Wijk RG, Haahtela T, Halken S, Ierodiakonou D, Iinuma T, Ivancevich JC, Jutel M, Kaidashev I, Khaitov M, Kalayci O, Kleine Tebbe J, Kowalski ML, Kuna P, Kvedariene V, La Grutta S, Larenas-Linnemann D, Lau S, Laune D, Le L, Lieberman P, Lodrup Carlsen KC, Lourenço O, Marien G, Carreiro-Martins P, Melén E, Menditto E, Neffen H, Mercier G, Mosgues R, Mullol J, Muraro A, Namazova L, Novellino E, O’Hehir R, Okamoto Y, Ohta K, Park HS, Panzner P, Passalacqua G, Pham-Thi N, Price D, Roberts G, Roche N, Rolland C, Rosario N, Ryan D, Samolinski B, Sanchez-Borges M, Scadding GK, Shamji MH, Sheikh A, Bom AT, Toppila-Salmi S, Tsiligianni I, Valentin-Rostan M, Valiulis A, Valovirta E, Ventura MT, Walker S, Waserman S, Yorgancioglu A, Zuberbier T; Allergic Rhinitis and Its Impact on Asthma Working Group. Next-generation Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines for allergic rhinitis based on Grading of Recommendations Assessment, Development and Evaluation (GRADE) and real-world evidence. The Journal of Allergy and Clinical Immunology. 2020;145(1):70-80.e3. https://doi.org/10.1016/j.jaci.2019.06.049
Bousquet J, Schünemann HJ, Hellings PW, Arnavielhe S, Bachert C, Bedbrook A, Bergmann KC, Bosnic-Anticevich S, Brozek J, Calderon M, Canonica GW, Casale TB, Chavannes NH, Cox L, Chrystyn H, Cruz AA, Dahl R, De Carlo G, Demoly P, Devillier P, Dray G, Fletcher M, Fokkens WJ, Fonseca J, Gonzalez-Diaz SN, Grouse L, Keil T, Kuna P, Larenas-Linnemann D, Lodrup Carlsen KC, Meltzer EO, Mullol J, Muraro A, Naclerio RN, Palkonen S, Papadopoulos NG, Passalacqua G, Price D, Ryan D, Samolinski B, Scadding GK, Sheikh A, Spertini F, Valiulis A, Valovirta E, Walker S, Wickman M, Yorgancioglu A, Haahtela T, Zuberbier T; MASK study group*. MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis. The Journal of Allergy and Clinical Immunology. 2016;138(2):367-374.e2. https://doi.org/10.1016/j.jaci.2016.03.025
Brożek JL, Bousquet J, Agache I, Agarwal A, Bachert C, Bosnic-Anticevich S, Brignardello-Petersen R, Canonica GW, Casale T, Chavannes NH, Correia de Sousa J, Cruz AA, Cuello-Garcia CA, Demoly P, Dykewicz M, Etxeandia-Ikobaltzeta I, Florez ID, Fokkens W, Fonseca J, Hellings PW, Klimek L, Kowalski S, Kuna P, Laisaar KT, Larenas-Linnemann DE, Lødrup Carlsen KC, Manning PJ, Meltzer E, Mullol J, Muraro A, O’Hehir R, Ohta K, Panzner P, Papadopoulos N, Park HS, Passalacqua G, Pawankar R, Price D, Riva JJ, Roldán Y, Ryan D, Sadeghirad B, Samolinski B, Schmid-Grendelmeier P, Sheikh A, Togias A, Valero A, Valiulis A, Valovirta E, Ventresca M, Wallace D, Waserman S, Wickman M, Wiercioch W, Yepes-Nuñez JJ, Zhang L, Zhang Y, Zidarn M, Zuberbier T, Schünemann HJ. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines-2016 revision. The Journal of Allergy and Clinical Immunology. 2017;140(4):950-958. https://doi.org/10.1016/j.jaci.2017.03.050
Dykewicz MS, Wallace DV, Baroody F, Bernstein J, Craig T, Finegold I, Huang F, Larenas-Linnemann D, Meltzer E, Steven G, Bernstein DI, Blessing-Moore J, Dinakar C, Greenhawt M, Horner CC, Khan DA, Lang D, Oppenheimer J, Portnoy JM, Randolph CR, Rank MA; Workgroup Chair and Cochair, Dykewicz MS, Wallace DV. Treatment of seasonal allergic rhinitis: An evidence-based focused 2017 guideline update. Annals of Allergy, Asthma and Immunology. 2017;119(6):489-511. https://doi.org/10.1016/j.anai.2017.08.012
Meltzer EO, Wallace D, Dykewicz M, Shneyer L. Minimal Clinically Important Difference (MCID) in Allergic Rhinitis: Agency for Healthcare Research and Quality or Anchor-Based Thresholds? Journal of Allergy and Clinical Immunology. In Practice. 2016;4(4):682-688.e6. https://doi.org/10.1016/j.jaip.2016.02.006
Glacy J, Putnam K, Godfrey S, Falzon L, Mauger B, Samson D, Aronson N. Treatments for Seasonal Allergic Rhinitis [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013. Report No.: 13-EHC098-EF.
Rot P, Rapiejko P, Jurkiewicz D. Intranasal steroid therapy — EPOS 2020. The Polish Otolaryngology. 2020;74(3):41-49. https://doi.org/10.5604/01.3001.0014.2449
Lipworth B, Newton J, Ram B, Small I, Schwarze J. An algorithm recommendation for the pharmacological management of allergic rhinitis in the UK: a consensus statement from an expert panel. NPJ Primary Care Respiratory Medicine. 2017;27(1):3. https://doi.org/10.1038/s41533-016-0001-y
Valera F, Tamashiro E, Anselmo-Lima WT. Glucocorticoid Resistance in the Upper Respiratory Airways. Chapter 20. 2012;523-538. https://doi.org/10.5772/53105
Lopatin AS, Svistushkin VM. Ostryj rinosinusit: etiologiya, patogenez, diagnostika i principy lecheniya. Klinicheskie rekomendatsii. M.: Umnyj doktor; 2009. (In Russ.).
Newton R. Anti-inflammatory glucocorticoids: changing concepts. European Journal of Pharmacology. 2014;724:231-236. https://doi.org/10.1016/j.ejphar.2013.05.035
Samolinski B, Arcimowicz M, reds. Alergologia Polska. Medycyna Praktyczna; 2012.
Derendorf H, Meltzer EO. Molecular and clinical pharmacology of intranasal corticosteroids: clinical and therapeutic implications. Allergy. 2008;63(10):1292-1300. https://doi.org/10.1111/j.1398-9995.2008.01750.x
Potter PC, Pawankar R. Indications, efficacy, and safety of intranasal corticosteriods in rhinosinusitis. The World Allergy Organization Journal. 2012;5(suppl 1):14-17. https://doi.org/10.1097/WOX.0b013e31823f7216
Suzaki H. Action mechanisms of glucocorticoids on rhinosinusitis. Asian Rhinology Journal. 2013;1:3-13.
Scadding G. Optimal management of nasal congestion caused by allergic rhinitis in children: safety and efficacy of medical treatments. Paediatric Drugs. 2008;10(3):151-162. https://doi.org/10.2165/00148581-200810030-00004
Zalmanovici A, Yaphe J. Steroids for acute sinusitis. The Cochrane Database of Systematic Reviews. 2007;(2):CD005149. https://doi.org/10.1002/14651858.CD005149.pub2
Bosnic-Anticevich S, Costa E, Menditto E, Lourenço O, Novellino E, Bialek S, Briedis V, Buonaiuto R, Chrystyn H, Cvetkovski B, Di Capua S, Kritikos V, Mair A, Orlando V, Paulino E, Salimäki J, Söderlund R, Tan R, Williams DM, Wroczynski P, Agache I, Ansotegui IJ, Anto JM, Bedbrook A, Bachert C, Bewick M, Bindslev-Jensen C, Brozek JL, Canonica GW, Cardona V, Carr W, Casale TB, Chavannes NH, Correia de Sousa J, Cruz AA, Czarlewski W, De Carlo G, Demoly P, Devillier P, Dykewicz MS, Gaga M, El-Gamal Y, Fonseca J, Fokkens WJ, Guzmán MA, Haahtela T, Hellings PW, Illario M, Ivancevich JC, Just J, Kaidashev I, Khaitov M, Khaltaev N, Keil T, Klimek L, Kowalski ML, Kuna P, Kvedariene V, Larenas-Linnemann DE, Laune D, Le LTT, Lodrup Carlsen KC, Mahboub B, Maier D, Malva J, Manning PJ, Morais-Almeida M, Mösges R, Mullol J, Münter L, Murray R, Naclerio R, Namazova-Baranova L, Nekam K, Nyembue TD, Okubo K, O’Hehir RE, Ohta K, Okamoto Y, Onorato GL, Palkonen S, Panzner P, Papadopoulos NG, Park HS, Pawankar R, Pfaar O, Phillips J, Plavec D, Popov TA, Potter PC, Prokopakis EP, Roller-Wirnsberger RE, Rottem M, Ryan D, Samolinski B, Sanchez-Borges M, Schunemann HJ, Sheikh A, Sisul JC, Somekh D, Stellato C, To T, Todo-Bom AM, Tomazic PV, Toppila-Salmi S, Valero A, Valiulis A, Valovirta E, Ventura MT, Wagenmann M, Wallace D, Waserman S, Wickman M, Yiallouros PK, Yorgancioglu A, Yusuf OM, Zar HJ, Zernotti ME, Zhang L, Zidarn M, Zuberbier T, Bousquet J. ARIA pharmacy 2018 «Allergic rhinitis care pathways for community pharmacy»: AIRWAYS ICPs initiative (European Innovation Partnership on Active and Healthy Ageing, DG CONNECT and DG Santé) POLLAR (Impact of Air POLLution on Asthma and Rhinitis) GARD Demonstration project. Allergy. 2019;74(7):1219-1236. https://doi.org/10.1111/all.13701
Ushkalova EA, Zyryanov SK, Shvarts GYa. Intranasal glucocorticosteroids in rhinosinusitis therapy: focus on mometasone furoate. Vestnik otorinolaringologii. 2016;81(5):59-66. (In Russ.). https://doi.org/10.17116/otorino201681559-66
Karpishchenko SA, Kolesnikova OM. The effectiveness of the combination of azelastine hydrochloride and mometasone furoate for intranasal use in patients with seasonal allergic rhinitis. Vestnik otorinolaringologii. 2017;82(5):44-47. (In Russ.). https://doi.org/10.17116/otorino201782544-47
Nosulya EV, Kim IA. Modern strategies for the treatment of allergic rhinitis. Vestnik otorinolaringologii. 2016;81(2):74-76. (In Russ.). https://doi.org/10.17116/otorino201681274-76
Wolthers OD. New patents of fixed combinations of nasal antihistamines and corticosteroids in allergic rhinitis. Recent Patents on Inflammation and Allergy Drug Discovery. 2013;7(3):223-228. https://doi.org/10.2174/1872213x113079990019.
Nenasheva NM. The effectiveness of the drug Momat rino advance in adult patients with seasonal allergic rhinitis. Results of a randomized open multicenter clinical trial. Rossijskaya otorinolaringologiya. 2016;81(2):137-147. (In Russ.). https://doi.org/10.18692/1810-4800-2016-2-137-147
https://doi.org/10.26442/2619-0079.2018.38-47 https://doi.org/10.26442/2619-0079.2018.38-4710.26442/2619-0079.2018.38-47
Meltzer E, Ratner P, Bachert C, Carr W, Berger W, Canonica GW, Hadley J, Lieberman P, Hampel FC, Mullol J, Munzel U, Price D, Scadding G, Virchow JC, Wahn U, Murray R, Bousquet J. Clinically relevant effect of a new intranasal therapy (MP29-02) in allergic rhinitis assessed by responder analysis. International Archives of Allergy and Immunology. 2013;161(4):369-377. https://doi.org/10.1159/000351404
Nenasheva NM, Ilina NI, Fedoskova TG. The effectiveness of the using combination of intranasal corticosteroids and antihistamines in adult patients with seasonal allergic rhinitis on the example of a fixed combination of mometasone furoate and azelastine hydrochloride nasal spray (the results of a clinical trial). Rossijskij allergologicheskij zhurnal. 2016;2:54-62. (In Russ.).
Klimek L., Bachert C., Pfaar O., Becker S., Bieber T., Brehler R., Buhl R., Casper I., Chaker A., Czech W., Fischer J., Fuchs T., Gerstlauer M., Karl Hörmann K., Thilo Jakob T., Jung K., Kopp M. V., Mahler V., Merk H., Mülleneisen N., Nemat K., Rabe U., Johannes Ring J., Saloga J., Schlenter W., Schmidt-Weber C., Seyfarth H., Sperl A., Spindler T., Staubach P., Strieth S., Treudler R., Vogelberg C., Wallrafen A., Wehrmann W., Wrede H., Zuberbier T., Bedbrook A., Canonica G.W., Cardona V., Casale T. B., Czarlewski W., Fokkens W. J., Hamelmann E., Jutel M., Mullol L.-L. D., Papadopoulos N. G., Toppila-Salmi S., Werfel T., and Bousquet J. ARIA guideline 2019: treatment of allergic rhinitis in the German health system. ARIA guideline (from Allergo J Int 2019; 28: 255-276.

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