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Gurov A.V.

N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia;
Sverzhevsky Research Institute of Clinical Otorhinolaryngology

Kryukov A.I.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology;
Pirogov Russian National Research Medical University

Levina Yu.V.

Pirogov Russian National Research Medical University;
Sverzhevsky Research Institute of Clinical Otorhinolaryngology

Bakhtin A.A.

National Medical Research Center of Otorhinolaryngology

Dubovaya T.K.

N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia

Murzakhanova Z.V.

N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia

Hearing dynamics in acute traumatic perforation of the tympanic membrane after application of blood plasma enriched with platelet growth factors

Authors:

Gurov A.V., Kryukov A.I., Levina Yu.V., Bakhtin A.A., Dubovaya T.K., Murzakhanova Z.V.

More about the authors

Journal: Russian Bulletin of Otorhinolaryngology. 2021;86(4): 23‑30

DOI: 10.17116/otorino20218604123

Read: 6323 times

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Table of contents

HEARING DYNAMICS IN ACUTE TRAUMATIC PERFORATION OF THE TYMPANIC MEMBRANE AFTER APPLICATION OF BLOOD PLASMA ENRICHED WITH PLATELET GROWTH FACTORS
HEARING DYNAMICS IN ACUTE TRAUMATIC PERFORATION OF THE TYMPANIC MEMBRANE AFTER APPLICATION OF BLOOD PLASMA ENRICHED WITH PLATELET GROWTH FACTORS

To cite this article:

Gurov AV, Kryukov AI, Levina YuV, Bakhtin AA, Dubovaya TK, Murzakhanova ZV. Hearing dynamics in acute traumatic perforation of the tympanic membrane after application of blood plasma enriched with platelet growth factors. Russian Bulletin of Otorhinolaryngology. 2021;86(4):23‑30. (In Russ.)
https://doi.org/10.17116/otorino20218604123

Подписка 2026 Вестник оториноларингологии (Russian Bulletin of Otorhinolaryngology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

The article considers the possibility of treating patients with acute traumatic perforation of the eardrum with a single application of blood plasma enriched with platelet-derived growth factors in the perforation area. As a result of the studies, it was found that the acceleration of its closure and the restoration of hearing.

MATERIAL AND METHODS

The study included 43 patients with unilateral acute PBP of various etiologies (Table 1). Patients were divided into 2 groups — the main — 24 patients (10 men and 14 women), the average age — 30±9.7 years and the control — 19 patients (9 men and 10 women), the average age — 26.5±6.37 years. The compared groups did not reliably differ in age, gender, frequency and severity of hearing impairment.

RESULTS

Analyzing the results, we can confidently talk about the beneficial effect of blood plasma enriched in platelet-derived growth factors on the speed, completeness of closure of traumatic perforation of the eardrum and the dynamics of restoration of auditory function. The use of blood plasma enriched with platelet growth factors led to a regular reduction in the time and increase in the frequency of cases of early closure of perforated eardrum, as well as improvement and restoration of auditory function according to the results of tonal threshold audiometry and otoacoustic emission in dynamics.

CONCLUSION

Being generally available even in outpatient practice, the method of a single application of blood plasma enriched with platelet growth factors in the area of perforation of the tympanic membrane can significantly accelerate the healing process of the tympanic membrane, while improving the quality of life of the patient.

Keywords:

perforation of the eardrum
blood plasma enriched with platelet growth factors
noise in the ear
hearing loss

Authors:

Gurov A.V.

N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia;
Sverzhevsky Research Institute of Clinical Otorhinolaryngology

Kryukov A.I.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology;
Pirogov Russian National Research Medical University

Levina Yu.V.

Pirogov Russian National Research Medical University;
Sverzhevsky Research Institute of Clinical Otorhinolaryngology

Bakhtin A.A.

National Medical Research Center of Otorhinolaryngology

Dubovaya T.K.

N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia

Murzakhanova Z.V.

N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia

Received:

08.07.2020

Accepted:

12.07.2021

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References:

  1. Onal K, Kazikdas KC, Uğuz MZ, Gursoy ST. A multivariate analysis of otological, surgical and patient-related factors in determining success in myringoplasty. Clinical Otolaryngology. 2005;30(2):115-120.  https://doi.org/10.1111/j.1365-2273.2004.00947.x
  2. Lee D, Honrado C, Har-El G, Goldsmith A. Pediatric temporal bone fractures. Laryngoscope. 1998;108(6):816-821.  https://doi.org/10.1097/00005537-199806000-00008
  3. Staroha AV, Davydov AV, Kocherov SN. Method of myringoplasty without filling the tympanic cavity with absorbable materials. Rossijskaya otorinolaringologiya. 2012;58(3):4-5. (In Russ.).
  4. Polyakova SD, Bateneva NN, Popova BA. An integrated approach to the diagnosis and treatment of traumatic otitis media. Rossijskaya otorinolaringologiya. 2009;41(4):114-118. (In Russ.).
  5. Muller R, Wichmann G. Mikrobiologische Befundo bei der chronischen otitis media. HNO Praxis. 1988;13(2):95-102. 
  6. Amonov ShE. Povyshenie ehffektivnosti hirurgicheskogo lecheniya hronicheskih gnojnyh srednih otitov. M.: Media Sfera; 2000. (In Russ).
  7. Semenov FV. Otomicroscopic examination of patients with middle ear pathology. Vestnik otorinolaringologii. 2001;4:48-50. (In Russ.).
  8. Kley W. Nachbehandlung und Nachsorge nach Horverbssernden Operationen. HNO. 1988;36(5):175-180. 
  9. Berger G, Finkelstein Y, Harell M. Non-explosive blast injury of the ear. The Journal of Laryngology and Otology. 1994;108(5):395-398.  https://doi.org/10.1017/s002221510012688x
  10. Shadyev HG, Vishnyakov VV. Experience of application of the surrounder and cartilage of the trammer and fascia of the temporal muscle in timpanoplasty. Vestnik otorinolaringologii: 1997;4:46-47. (In Russ.).
  11. Garov EV, Kryukov AI, Zelenkova VN, Sidorina NG, Kaloshina AS. Atypical course of inflammation in the middle ear. Vestnik otorinolaringologii. 2017:82(4):9-15. (In Russ.). https://doi.org/10.17116/otorino20178249-15
  12. Tumanov VP, Pal’chun VT, Pomatilov AA, Polyakova EV, Zakharova AV, Yarygin VN. Modern cell technologies in the treatment of patients with tympanic membrane injury inflicted by mine explosion. Vestnik otorinolaringologii. 2006;2:92-95. (In Russ.).
  13. Krotov Yu.A. Myringoplasty with extensive perforations of the eardrum. Vestnik otorinolaringologii. 2001;5:57-59. (In Russ.).
  14. Xu Z. Analysis on characters of 220 cases of tympani membrane perforated. Fa Yi Xue Za Zhi. 2001;17(1):28-62. 
  15. Pal’chun VT, Kunel’skaya NL, Polyakova EP, Mal’chenko OV, Levina YuV. The condition of auditory and vestibular analyzers in patients with a mine-explosive injury. Vestnik otorinolaringologii. 2006;4:24. (In Russ.).
  16. Rosli C, Sim JH, Chatzimichalis M, Huber A.M. How does closure of tympanic membrane perforations affect hearing and middle ear mechanics? An evaluation in a patient cohort and temporal bone models. Otology and Neurotology. 2012;33(3):371-378.  https://doi.org/10.1097/MAO.0b013e31824296ee
  17. Weber PC. Vertigo and disequilibrium: a practical guide to diagnosis and management. NY: Thieme Publishing Group; 2008.
  18. Weyrich AS, Schwertz H, Zimmerman G. Protein synthesis by platelets: historical and new perspectives. Journal of Thrombosis and Haemostasis. 2009;7(2):241-246.  https://doi.org/10.1111/j.1538-7836.2008.03211.x
  19. Anitua E, Andia I, Sanchez M, Azofra J, del Mar Zalduendo M, de la Fuente M, Nurden P, Nurden A.T. Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in culture. Journal of Orthopaedic Research. 2009;23(2)281-286.  https://doi.org/10.1016/j.orthres.2004.08.015
  20. Semenov FV. Otoendoscopic evaluation of long-term results of tympanoplasty performed using platelet-rich plasma. Rossijskaya otorinolaringologiya. 2013;64(3):132-135. (In Russ.).
  21. Zav’yalov FN, Goncharova OG. The use of platelet-rich autoplasma in sanitizing operations on the middle ear. Rossijskaya otorinolaringologiya. 2008;2:24-27. (In Russ.).
  22. Hajiioannou JK, Bizaki A, Fragiadakis G, Bourolias C, Spanakis I, Chlouverakis G, Bizakis J. Optimal time for nasal packing removal after septoplasty. A comparative study. Rhinology. 2007;45(1):68-71. 
  23. Gurov AV, El’chaninov AV, Murzakhanova ZV. Application of blood plasma enriched with platelet derived growth factors in experimental perforation of the tympanic membrane. Meditsinskiy Sovet. 2019;20:108-114. (In Russ.). https://doi.org/10.21518/2079-701X-2019-20-108-114
  24. Requel CA, Requel S, Granja PL. Fibroblasts as maestros orchestrating tissue regeneration. Journal of Tissue Engineering and Regenerative Medicine. 2018;12(1):240-251.  https://doi.org/10.1002/term.2405
  25. Yaşar M, Kaya A, Karaman H, Kavugudurmaz M, Polat H, Sağıt M, Özcan İ. Potential Curative Role of Hypericum Perforatum in an Experimental Rat Model of Tympanic Membrane Perforation. The Journal of International Advanced Otology. 2016;12 (3):252-256.  https://doi.org/10.5152/iao.2016.1612
  26. Mei-Dan O, Carmont M, Laver N, Nyska M. Standardization of the functional syndesmosis widening by dynamic US examination. BMC Sports Science, Medicine and Rehabilitation. 2013;5:9.  https://doi.org/10.1186/2052-1847-5-9.
  27. Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiological Reviews. 2003;83(3):835-870.  https://doi.org/10.1152/phys-rev.2003.83.3.835
  28. Eppley B, Pietrzak W, Blanton M. Platelet-rich plasma: a review of biology and applications in plastic surgery. Plastic and Reconstructive Surgery. 2006;118(6):147-159.  https://doi.org/10.1097/01.prs.0000239606.92676.cf
  29. Svistushkin VM, Timashev PS, Zolotova AV, Mokoyan ZT. Tissue-engineering approach to closure of persistent eardrum perforations. Meditsinskiy Sovet. 2019;8:132-136. (In Russ.). https://doi.org/10.21518/2079-701X-2019-8-132-136
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