The question about the topical antibiotic therapy of acute rhinosinusitis

Krivopalov A.A.

St.-Petersburg Research Institute of Ear, Nose, Throat, and Speech, Russian Ministry of Health, St.-Petersburg, Russia, 190013

Riazantsev S.V.

Sankt-Peterburgskiĭ NII ukha, gorla, nosa i rechi Minzdrava Rossii

Eremin S.A.

"Detskaia gorodskaia poliklinika #17", Sankt-Peterburg

Zakharova G.P.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

Shabalin V.V.

Saint-Petersburg Institute of Ear, Nose, Throat and Speech, St.-Petersburg, Russia, 190013

Shamkina P.A.

Saint-Petersburg Institute of Ear, Nose, Throat and Speech, St.-Petersburg, Russia, 190013

Chernushevich I.I.

Otdel diagnostiki i reabilitatsii narusheniĭ slukha Sankt-Peterburgskogo NII ukha, gorla, nosa i rechi, Sankt-Peterburg, Rossiia, 190013

The question about the topical antibiotic therapy of acute rhinosinusitis

Authors:

Krivopalov A.A., Riazantsev S.V., Eremin S.A., Zakharova G.P., Shabalin V.V., Shamkina P.A., Chernushevich I.I.

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Journal: Russian Bulletin of Otorhinolaryngology. 2019;84(2): 50‑56

DOI: 10.17116/otorino20198402150

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Krivopalov AA, Riazantsev SV, Eremin SA, Zakharova GP, Shabalin VV, Shamkina PA, Chernushevich II. The question about the topical antibiotic therapy of acute rhinosinusitis. Russian Bulletin of Otorhinolaryngology. 2019;84(2):50‑56. (In Russ.)
https://doi.org/10.17116/otorino20198402150

Подписка 2025 (Russian Bulletin of Otorhinolaryngology)

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Presented the results of the clinical study of 30 patients with moderate rhinosinusitis (13 (43.3%) men, 17 (56.7%) women, age from 18 to 68 years). Among those patients, the inflammation of one paranasal sinus was observed in 7 (23.3%) cases, polysinusitis was observed in 23 (76. 7%) cases. All patients were randomized into 2 groups of 15 people. In both groups, patients received systemic antibiotic therapy, nasal irrigation therapy, and NSAIDs. In the control group, topical decongestants were used; in the experimental group the antimicrobial drug Polydexa with phenylephrine was used as a local therapy. The purpose of the study was to evaluate the clinical efficacy of Polydexa with phenylephrine in the complex treatment of moderate acute rhinosinusitis. The evaluation criteria were statistically significant comparison of clinical and laboratory parameters of both groups. Confirmed the anti-inflammatory, antimicrobial effects of the drug, made conclusions about the significant clinical efficacy, tolerability, positive effect on mucociliary clearance and safety of nasal spray Polydexa with phenylephrine.

Keywords:

acute sinusitis

rhinosinusitis

antibiotic therapy

local therapy

Polydexa with phenylephrine

Authors:

Krivopalov A.A.

St.-Petersburg Research Institute of Ear, Nose, Throat, and Speech, Russian Ministry of Health, St.-Petersburg, Russia, 190013

Riazantsev S.V.

Sankt-Peterburgskiĭ NII ukha, gorla, nosa i rechi Minzdrava Rossii

Eremin S.A.

"Detskaia gorodskaia poliklinika #17", Sankt-Peterburg

Zakharova G.P.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

Shabalin V.V.

Saint-Petersburg Institute of Ear, Nose, Throat and Speech, St.-Petersburg, Russia, 190013

Shamkina P.A.

Saint-Petersburg Institute of Ear, Nose, Throat and Speech, St.-Petersburg, Russia, 190013

Chernushevich I.I.

Otdel diagnostiki i reabilitatsii narusheniĭ slukha Sankt-Peterburgskogo NII ukha, gorla, nosa i rechi, Sankt-Peterburg, Rossiia, 190013

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