The question about the topical antibiotic therapy of acute rhinosinusitis

Krivopalov A.A.; Riazantsev S.V.; Eremin S.A.; Zakharova G.P.; Shabalin V.V.; Shamkina P.A.; Chernushevich I.I.

doi:https://doi.org/10.17116/otorino20198402150

Krivopalov A.A.

St.-Petersburg Research Institute of Ear, Nose, Throat, and Speech, Russian Ministry of Health, St.-Petersburg, Russia, 190013

Riazantsev S.V.

Sankt-Peterburgskiĭ NII ukha, gorla, nosa i rechi Minzdrava Rossii

Eremin S.A.

"Detskaia gorodskaia poliklinika #17", Sankt-Peterburg

Zakharova G.P.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

Shabalin V.V.

Saint-Petersburg Institute of Ear, Nose, Throat and Speech, St.-Petersburg, Russia, 190013

Shamkina P.A.

Saint-Petersburg Institute of Ear, Nose, Throat and Speech, St.-Petersburg, Russia, 190013

Chernushevich I.I.

Otdel diagnostiki i reabilitatsii narusheniĭ slukha Sankt-Peterburgskogo NII ukha, gorla, nosa i rechi, Sankt-Peterburg, Rossiia, 190013

The question about the topical antibiotic therapy of acute rhinosinusitis

Authors:

Krivopalov A.A., Riazantsev S.V., Eremin S.A., Zakharova G.P., Shabalin V.V., Shamkina P.A., Chernushevich I.I.

More about the authors

Journal: Russian Bulletin of Otorhinolaryngology. 2019;84(2): 50‑56

DOI: 10.17116/otorino20198402150

Read: 2161 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Krivopalov AA, Riazantsev SV, Eremin SA, Zakharova GP, Shabalin VV, Shamkina PA, Chernushevich II. The question about the topical antibiotic therapy of acute rhinosinusitis. Russian Bulletin of Otorhinolaryngology. 2019;84(2):50‑56. (In Russ.)
https://doi.org/10.17116/otorino20198402150

Подписка 2026 Вестник оториноларингологии (Russian Bulletin of Otorhinolaryngology)

Использование инфографики авторами научных работ

Close metadata

Recommended articles:

Experimental and clinical evaluation of the safety and efficacy of Polydexa spray with phenylephrine in acute rhinosinusitis. Russian Bulletin of Otorhinolaryngology. 2025;(4):39-46

The role of Inflasinusans in the treatment of acute rhinosinusitis. Russian Bulletin of Otorhinolaryngology. 2025;(4):64-71

Rhinogenic orbital complications in children of the first year of life. Russian Bulletin of Otorhinolaryngology. 2025;(5):41-47

Effectiveness of plant mucolytic agent application in surgical practice. Russian Bulletin of Otorhinolaryngology. 2025;(6):84-88

Contradictory indications for rhinosinus surgery in children with rhinogenic headaches. Russian Bulletin of Otorhinolaryngology. 2025;(6):111-118

Autoimmune hearing loss in giant cell arteritis: a clinical case. Russian Bulletin of Otorhinolaryngology. 2026;(1):86-92

Evaluation of the effect of the enzyme preparation Phlogenzym on the ability of clinical strains isolated from surgical wounds to form biofilms. Pirogov Russian Journal of Surgery. 2025;(10):88-94

Results of olfactory examination in patients with rhinosinusitis based on various olfactory tests. Russian Rhinology. 2025;(4):6-12

Antibiotic therapy in children with ent diseases. Russian Rhinology. 2026;(1):54-62

Abstract:

Presented the results of the clinical study of 30 patients with moderate rhinosinusitis (13 (43.3%) men, 17 (56.7%) women, age from 18 to 68 years). Among those patients, the inflammation of one paranasal sinus was observed in 7 (23.3%) cases, polysinusitis was observed in 23 (76. 7%) cases. All patients were randomized into 2 groups of 15 people. In both groups, patients received systemic antibiotic therapy, nasal irrigation therapy, and NSAIDs. In the control group, topical decongestants were used; in the experimental group the antimicrobial drug Polydexa with phenylephrine was used as a local therapy. The purpose of the study was to evaluate the clinical efficacy of Polydexa with phenylephrine in the complex treatment of moderate acute rhinosinusitis. The evaluation criteria were statistically significant comparison of clinical and laboratory parameters of both groups. Confirmed the anti-inflammatory, antimicrobial effects of the drug, made conclusions about the significant clinical efficacy, tolerability, positive effect on mucociliary clearance and safety of nasal spray Polydexa with phenylephrine.

Keywords:

acute sinusitis

rhinosinusitis

antibiotic therapy

local therapy

Polydexa with phenylephrine

Authors:

Krivopalov A.A.

St.-Petersburg Research Institute of Ear, Nose, Throat, and Speech, Russian Ministry of Health, St.-Petersburg, Russia, 190013

Riazantsev S.V.

Sankt-Peterburgskiĭ NII ukha, gorla, nosa i rechi Minzdrava Rossii

Eremin S.A.

"Detskaia gorodskaia poliklinika #17", Sankt-Peterburg

Zakharova G.P.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

Shabalin V.V.

Saint-Petersburg Institute of Ear, Nose, Throat and Speech, St.-Petersburg, Russia, 190013

Shamkina P.A.

Saint-Petersburg Institute of Ear, Nose, Throat and Speech, St.-Petersburg, Russia, 190013

Chernushevich I.I.

Otdel diagnostiki i reabilitatsii narusheniĭ slukha Sankt-Peterburgskogo NII ukha, gorla, nosa i rechi, Sankt-Peterburg, Rossiia, 190013

Close metadata

References:

Bachert C, Alobid I, Baroody F, Cohen N, Cervin A, Douglas R, Gevaer P, Georgalas C, Goossens H, Harvey R, Hellings P, Hopkins C, Jones N, Joos G, Kalogjera L, Kern B, Kowalski M, Price D, Riechelmann H, Schlosser R, Senior B, Thomas M, Toskala E, Voegels R, Wang DY, Wormald PJ. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinology. 2012;50(1):1-12.
Meltzer EO, Bachert C, Staudinger H. Treating acute rhinosinusitis: comparing efficacy and safety of mometasone furoate nasal spray, amoxicillin, and placebo. J Allergy Clin Immunol. 2005;116(6):1289-1295.
Ebell MH, McKay B, Guilbault R, Ermias Y. Diagnosis of acute rhinosinusitis in primary care: a systematic review of test accuracy. Br J Gen Pract. 2016;66(650):612-632.
Leggett JE. Acute sinusitis. Postgraduate Medicine. 2004;115(1):13-19.
Karpova EP, Feizullayev EF. New approaches to noninvasive therapy for acute rhinosinusitis in adolescents. Vestnik Otorinolaringologii. 2008;2:70-72. (In Russ.)
Ryazansev SV. The principles of etiopathogenetic treatment of acute sinusitis. Medicinskij Sovet. 2014;15:13-17. (In Russ.)
Revai K, Dobbs LA, Nair S, Patel JA, Grady JJ, Chonmaitree T. Incidence of acute otitis media and sinusitis complicating upper respiratory tract infection: the effect of age. Pediatrics. 2007;119(6):1408-1412.
Feldt B, Dion GR, Weitzel EK, McMains KC. Acute Sinusitis. Southern Medical Journal. 2013;106(10):577-581.
Rosenfeld RM, Andes D, Bhattacharyya N, Cheung D, Eisenberg S, Ganiats TG, Gelzer A, Hamilos D, Haydon RC III, Hudgins PA, Jones S, Krouse HJ, Lee LH, Mahoney MC, Marple BF, Mitchell JP, Nathan R, Shiffman RN, Smith TL, Witsel DL. Clinical practice guideline: adult sinusitis. Otolaryngol Head Neck Surg. 2007;137:1-31.
Wald ER. Sinusitis in children. New England Journal of Medicine. 1992;326(5):319-323.
Ovchinnikov AYu, Edzhe MA. Efficacy and safety of different antibiotic regimens in patients with acute rhinosinusitis or exacerbation of chronic rhinosinusitis. Medicinskij Sovet. 2015;3:8-13 (In Russ.)