Rational pharmacotherapy of the pathologically changed immune system of nasal mucosa in the patients presenting with allergic rhinitis

Close metadata

Recommended articles:

Modern approaches to rational combination pharmacotherapy of allergic rhinitis. Russian Bulletin of Otorhinolaryngology. 2024;(4):68-77

Effectiveness of fixed combination of olopatadine hydrochloride and mometasone furoate in adults and children with allergic rhinitis in real-life clinical practice settings: results of «RYAL» prospective observational study. Russian Rhinology. 2024;(1):16-26

Modern aspects of immune pathogenesis and diagnosis of nosocomial pulmonary infections in surgical patients. Russian Journal of Anesthesiology and Reanimatology. 2024;(4):90-96

Esophageal pathology and bronchial asthma: pathogenetic interactions and possibilities for therapy optimization. Russian Journal of Preventive Medicine. 2024;(11):129-134

The objective of the present study was to analyse modern concepts of pathogenesis of local immune changes in nasal mucosa associated with allergic rhinitis (AR) and the currently available methods for rational pharmacotherapy of this condition. The factors of local congenital and adaptive immunity inherent in nasal mucosa are considered in conjunction with the changes of immune characteristics in the patients presenting with allergic rhinitis. It is concluded based on the literature data that the local cytokine profile has the highest informative value for the description of the inflammatory process in nasal mucosa. The author undertakes the comparative assessment of the pharmaceutical products available for the rational treatment of allergic rhinitis and related mucosal pathology by the correction of disturbed local immunity. Special attention is given to the application of glucocorticoids (including topical ones), antihistamine preparations, and immunomodulators, such as cycloferon. It is concluded that the use of cycloferon for local pharmacotherapy makes it possible to maximally enhance the immune response and thereby improve the results of the specific treatment.

Keywords:

allergic rhinitis

mucosal immunity

cycloferon

local immunotherap

Authors:

Tataurshchikova N.S.

Laboratoriia biotekhnologii Instituta immunologii FMBA RF, Moskva

List of references:

Meditsinskaya mikrobiologiya, virusologiya i immunologiya: tom 1. Uchebnik. Pod red. V.V. Zvereva, M.N. Boichenko. M: GEOTAR-Media 2010; 395-403.
Dempsey P.W., Validya S.A., Cheng G. The art of war: Innate and adaptive immune responses. Cell Mol Life Sci 2003; 60: 2604-2621.
Medzhitov R., Biron C.A. Innate immunity. Curr Opin Immunol 2003; 15: 2-4.
Guseva E.D. Sostoyanie mestnogo gumoral'nogo immuniteta u detei s allergicheskim rinitom i effektivnost' lecheniya gomeopaticheskim preparatom korizaliya: Avtoref. dis. … kand. med. nauk. Ufa 2005.
Tataurshchikova N.S., Degtyareva E.A., Krasnov V.V., Romantsov M.G. Immunokomprometirovannyi bol'noi. SPb Izd-vo "Taktik studio" 2009.
Maurizi M., Paludetti G., Todisco T., Almadori G., Ottaviani F., Zappone C. Ciliary ultrastructure and nasal mucociliary clearance in chronic and allergic rhinitis. Rhinology 1984; 22: 4: 233-240.
Yang P.C. Investigation of the nasal mucosa in perennial allergic rhinitis with SEM and TEM. Zhonghua Er Bi Yan Hou Ke Za Zhi 1990; 25: 2: 95-96, 126.
Kirtsreesakul V., Somjareonwattana P., Ruttanaphol S. The correlation between nasal symptom and mucociliary clearance in allergic rhinitis. Laryngoscope 2009; 119: 8: 1458-1462.
The Cytokine Handbook. Ed. A.W. Thomson, M.T. Lotze. London San Diego "Academic Press 2003.
Dem'yanov A.V., Kotov A.Yu., Simbirtsev A.S. Diagnosticheskaya tsennost' issledovaniya urovnei tsitokinov v klinicheskoi praktike. Tsitokiny i vospalenie 2003; 3: 20-35.
Simbirtsev A.S. Tsitokinonovaya sistema regulyatsii zashchitnykh reaktsii organizma. Tsitokiny i vospalenie 2002; 1: 9-16.
Tataurshchikova N.S., Sidorovich I.G. Tsitokinovyi status kak kriterii effektivnosti intranazal'noi aerozol'terapii rastvorom tsikloferona v lechenii allergicheskogo rinosinusita. Vestn otorinolar 2012; 3: 79-82.
Prosekova E. V., Netesova S.Yu., V.A. Sabynych N.R., Zabelina O.V., Shchegoleva. Kliniko-laboratornyi algoritm diagnostiki allergicheskogo rinita u detei. Dal'nevostochnyi med zhurn 2012; 3: 76-80.
Klinicheskie rekomendatsii po diagnostike i lecheniyu allergicheskogo rinita. Consilium medicum 2001; 33-44.
Tataurshchikova N.S. Tsikloferon v klinicheskoi allergologii. SPb Izd-vo "Taktik studio" 2010.
Simbirtsev A.S. Tsitokiny v immunopatogeneze i lechenii allergii. RAZh 2007; 1: 5-20.
Liu Y.H., Tao Z.Z. Effect of intranasal glucocorticoid on the pathological change of nasal mucosa in rats with allergic rhinitis. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2009; 44: 11: 935-940.
Salter M., Biggadike K., Matthews J.L., West M.R., Haase M.V., Farrow S.N., Uings I.J., Gray D.W. Pharmacological propeties of the enhanced-affinity glucocorticoid fluticasone furoate in vitro and in vivo model of respiratory inflammatory disease. Am J Physiol Lung Cell Mol Physiol 2007; 293: 660-667.
Il'ina N.I., Fedenko E.S., Kurbacheva O.M. Allergicheskii rinit. Posobie dlya vrachei obshchei praktiki i farmatsevtov. Rosa allergol zhurn (Prilozhenie) 2004, s.12.
Barron S., Ramis I.,García-Rafanell J., Merlos M. Inhibitory activity of rupatadine on pro-inflammatory cytokine production, relationship with binding affinity [abstract]. Methods Find Exp Clin Pharmacol 2005; 27: Suppl 2:161-162.
Queralt M., Brazis P., Merlos M., de Mora F., Puigdemont A. In vitro inhibitory effect of rupatadine on histamine and TNF-alpha release from dispersed canine skin mast cells and the human mast cell line HMC-1. Inflamm Res 2000; 49: 355-360.
Vasiadi M., Kalogeromitros D., Kempuraj D., Clemons A., Zhang B., Chliva C., Makris M., Wolfberg A., House M., Theoharides T.C. Rupatadine Inhibits Proinflammatory Mediator Secretion from Human Mast Cells Triggered by Different Stimuli. Int Arch Allergy Immunol 2010; 151: 38-45.
Gushchin I.S. Tsetirizin - etalon N1-antigistaminnogo sredstva. M 2000.
Tataurshchikova N.S., Sepiashvili R.I. Sovremennye podkhody k ispol'zovaniyu immunomodulyatorov v allergologicheskoi praktike. Uchebno-metod posobie. M 2012; 40.
Tataurshchikova N.S., Sidorovich I.G. Novoe v lokal'noi imunoterapii allergicheskogo rinosinusita - intranazal'naya aerozol'terapi rastvorom tsikloferona. Vestn otorinolar 2012; 2: 49-53.
Romantsov M.G., Kovalenko A.L. Induktor interferona - tsikloferon: Itogi i perspektivy klinicheskogo primeneniya: Rekomendatsii dlya vrachei. SPb: OOO "Semaks" 2007; 24.
Romantsov M.G., Kovalenko A.L. Kharakteristika tsikloferona, immunomodulyatora s polifunktsional'noi aktivnost'yu. V kn.: Tsikloferon v klinicheskoi pul'monologii: Posobie dlya vrachei. SPb: Taktik-Studio 2005; 9-14.
Romantsov M.G., Ershov F.I. Lekarstvennye sredstva, primenyaemye pri virusnykh zabolevaniyakh: Rukovodstvo dlya vrachei. M: GEOTAR-Mediya 2007; 363.
Tataurshchikova N.S. Osobennosti allergopatologii u lits, podvergshikhsya radiatsionnomu vozdeistviyu (kliniko-immunologicheskaya kharakteristika i metodicheskie podkhody k terapii): Avtoref. dis. … d-ra med. nauk. M 2002; 40.

Close metadata