The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Andreeva Yu.S.

Krasnov Research Institute of Eye Diseases

Alkharki L.

Krasnov Research Institute of Eye Diseases

Budzinskaya M.V.

Krasnov Research Institute of Eye Diseases

Changes in intraocular pressure and biometric parameters of the anterior segment of the eye after intravitreal injections

Authors:

Andreeva Yu.S., Alkharki L., Budzinskaya M.V.

More about the authors

Journal: Russian Annals of Ophthalmology. 2024;140(2‑2): 7‑15

DOI: 10.17116/oftalma20241400227

Read: 1683 times

Download PDF (RU)
Contact the author
Table of contents

CHANGES IN INTRAOCULAR PRESSURE AND BIOMETRIC PARAMETERS OF THE ANTERIOR SEGMENT OF THE EYE AFTER INTRAVITREAL INJECTIONS
CHANGES IN INTRAOCULAR PRESSURE AND BIOMETRIC PARAMETERS OF THE ANTERIOR SEGMENT OF THE EYE AFTER INTRAVITREAL INJECTIONS

To cite this article:

Andreeva YuS, Alkharki L, Budzinskaya MV. Changes in intraocular pressure and biometric parameters of the anterior segment of the eye after intravitreal injections. Russian Annals of Ophthalmology. 2024;140(2‑2):7‑15. (In Russ.)
https://doi.org/10.17116/oftalma20241400227

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Iris mela­noma: correlation of clinical, morphometric, pathomorphological features and infe­ctious status. Russian Annals of Ophthalmology. 2025;(1):13-20
Long-term outcomes of phakic intraocular lens implantation in high myopia. Russian Annals of Ophthalmology. 2025;(1):28-31
Primary angle closure suspects: application of machine learning method for substantiation of close moni­toring. Russian Annals of Ophthalmology. 2025;(2):67-74
The effect of initial conservative hypo­tensive therapy on the outcomes of sele­ctive laser trabeculoplasty in primary open-angle glaucoma. Russian Annals of Ophthalmology. 2025;(5):16-22
Modern devi­ces for microinvasive glaucoma surgery. Russian Annals of Ophthalmology. 2025;(5):101-108
Abstract:

PURPOSE

This study compares the changes in the parameters of the anterior chamber of the eye using anterior segment optical coherence tomography (AS-OCT) in patients with a natural and artificial lens after treatment of neovascular age-related macular degeneration (nAMD) by multiple intravitreal injections (IVI) of anti-VEGF drugs.

MATERIAL AND METHODS

The patients were divided into 2 groups: group 1 (control) included 30 patients (30 eyes) with a natural lens, group 2 — 30 patients (30 eyes) with an intraocular lens (IOL). AS-OCT was performed using the Revo NX tomograph (Optopol, Poland) to analyze anterior chamber depth (ACD) and the parameters of anterior chamber angle (ACA). Intraocular pressure (IOP) was measured with a contact tonometer ICare Pro.

RESULTS

In patients with an IOL, the IOP level 1 minute after intravitreal injection (IVI) of an anti-VEGF drug was statistically lower than in the control group, on average by 17.8% during the first IVI and by 28.7% after 1 year of observation (p<0.001). ACD before treatment was statistically significantly higher in patients with IOL compared to patients of group 1 by an average of 39.3% (p<0.001). ACA from the nasal and temporal sides in the meridian 0°—180° before the start of treatment was statistically significantly wider in phakic patients than in the control group, by an average of 15.9±9.3° (p<0.001) and 16.9±8.2° (p<0.001), respectively. According to AS-OCT, there was no shift of the iris-lens diaphragm in patients with an IOL after multiple IVI of an anti-VEGF drug, in contrast to the control group.

CONCLUSIONS

AS-OCT was used to determine for the first time the changes in the parameters of the anterior chamber of the eye in patients with a natural and artificial lens after multiple injections of an anti-VEGF drug in the treatment of nAMD.

Keywords:

anti-VEGF drugs
intravitreal injection
intraocular pressure
anterior segment optical coherence tomography

Authors:

Andreeva Yu.S.

Krasnov Research Institute of Eye Diseases

Alkharki L.

Krasnov Research Institute of Eye Diseases

Budzinskaya M.V.

Krasnov Research Institute of Eye Diseases

Received:

27.12.2023

Accepted:

11.02.2024

Close metadata

References:

  1. Campell J, Bronskill S, Bell C, Paterson M, Whitehead M, Gill SS. Rapid. expansion of intravitreal drug injection procedures, 2000 to 2008: a population-based analysis. Arch Ophthalmol. 2010;128:359-362. 
  2. Rosenfeld PJ, Brown DM, Heier JS, Boyer DS, Kaiser PK, Chung CY, et al. MARINA Study Group. Ranibizumab for neovascular age related macular degeneration. N Engl J Med. 2006;355:1419-1431.
  3. Brown DM, Kaiser PK, Michels M, Soubrane G, Heier JS, Kim RY, et al. ANCHOR Study Group. Ranibizumab versus verteporfirin for neovascular age-related macular degeneration. N Engl J Med. 2006;355:1432-1444.
  4. Budzinskaya MV, Plyukhova AA, Alkharki L. Modern trends in anti-VEGF therapy for age-related macular degeneration. Russian Annals of Ophthalmology = Vestnik oftal’mologii. 2023;139(3-2):46-50. (In Russ.). https://doi.org/10.17116/oftalma202313903246
  5. Falavarjani KG, QD Nguyen. Adverse events and complications associated with in-travitreal injection of anti-VEGF agents: a review of literature. Eye. 2013;27:787-894.  https://doi.org/10.1038/eye.2013.107
  6. Plyukhova AA, Budzinskaya MV, Starostin KM, Rejdak R, Bucolo C, Reibaldi M, Toro MD. Comparative safety of bevacizumab, ranibizumab, and aflibercept for treatment of neovascular age-related macular degeneration (AMD): A systematic review and network meta-analysis of direct comparative studies. J Cl Med. 2020;9(5):522.  https://doi.org/10.3390/jcm9051522
  7. Hollands H, Wong J, Bruen R, et al. Short-term intraocular pressure changes after intravitreal injection of bevacizumab. Can J Ophthalmol. 2007;42: 807-811.  https://doi.org/10.3129/i07-172
  8. Kim JE, Mantravadi AV, Hur EY, Covert DJ. Short-term intra- ocular pressure changes immediately after intravitreal injec- tions of anti-vascular endothelial growth factor agents. Am J Ophthalmol. 2008;146:930-934.e931. https://doi.org/10.1016/j.ajo.2008.07.007
  9. Wen J, Cousins S, Schuman S, Allingham R. Dynamic changes of the anterior chamber angle produced by intravitreal anti-vascular growth factor injections. Retina. 2016;36(10):1874-1881. https://doi.org/10.1097/IAE.0000000000001018
  10. Wingard J, Darcie A, Houlihan N, Lin J, Gieser J. Incidence of glaucoma or ocular hypertension after repeated anti-vascular endothelial growth factor injections for macular degeneration. Clinical Ophthalmology. 2019;13:2563-2572. https://doi.org/10.1016/j.ajo.2004.04.054
  11. Alkin Z, Perente I, Altan C, et al. Changes in Anterior Segment Morphology after Intravitreal Injection of Bevacizumab and Bevacizumab — triamcinolone Acetate Combination. Eur J Ophthalmol. 2013;23(4):504-509.  https://doi.org/10.5301/ejo.5000241
  12. Alaghband P, Beltran-Agulló L, Galvis E, Overby D, Lim K. Effect of phacoemulsification on facility of outflow. Br J Ophthalmol. 2018;102(11):1520-1526. https://doi.org/10.1136/bjophthalmol-2017-311548
  13. Bakri SJ, Moshfeghi DM, Francom S, et al. Intraocular pressure in eyes receiving monthly ranibizumab in 2 pivotal age- related macular degeneration clinical trials. Ophthalmology. 2014;121:1102-1108. https://doi.org/10.1016/j.ophtha.2013.11.029
  14. Nolan P, See L, Friedman, David S, Chan, Yiong-Huak. Changes in Angle Configuration After Phacoemulsification Measured by Anterior Segment Optical Coherence Tomography. Journal of Glaucoma. 2008;17(6):455-459.  https://doi.org/10.1097/IJG.0b013e3181650f31
  15. Brown H., Zhong, Le, Whitman L., Lynch, Mary G.; Kilgo, Patrick D.; Hovis, Kristen L. Reduced intraocular pressure after cataract surgery in patients with narrow angles and chronic angle-closure glaucoma. J Cataract Refract Surg. 2014;40(10):1610-1614. https://doi.org/10.1016/j.jcrs.2014.01.038
  16. Poley BJ, Lindstrom RL, Samuelson TW. Longterm effects of phacoemulsification with intraocular lens implantation in normotensive and ocular hypertensive eyes. J Cataract Refract Surg. 2008;34:735-742.  https://doi.org/10.1016/j.jcrs.2007.12.045
  17. Barzanouni E, Idani D, Sharifipour F. In Vivo Intraocular Lens Thickness Measurement and Power Estimation Using Optical Coherence Tomography. J Ophthalmic Vis Res. 2022;17(3):353-359.  https://doi.org/10.18502/jovr.v17i3.11572
  18. Guler M, Capkin M, Simsek A, et al. Short-term effects of intravitreal bevacizumab on cornea and anterior chamber. Curr Eye Res. 2014;39:989-993.  https://doi.org/10.3109/02713683.2014.888452
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.