Changes in intraocular pressure and biometric parameters of the anterior segment of the eye after intravitreal injections

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PURPOSE

This study compares the changes in the parameters of the anterior chamber of the eye using anterior segment optical coherence tomography (AS-OCT) in patients with a natural and artificial lens after treatment of neovascular age-related macular degeneration (nAMD) by multiple intravitreal injections (IVI) of anti-VEGF drugs.

MATERIAL AND METHODS

The patients were divided into 2 groups: group 1 (control) included 30 patients (30 eyes) with a natural lens, group 2 — 30 patients (30 eyes) with an intraocular lens (IOL). AS-OCT was performed using the Revo NX tomograph (Optopol, Poland) to analyze anterior chamber depth (ACD) and the parameters of anterior chamber angle (ACA). Intraocular pressure (IOP) was measured with a contact tonometer ICare Pro.

RESULTS

In patients with an IOL, the IOP level 1 minute after intravitreal injection (IVI) of an anti-VEGF drug was statistically lower than in the control group, on average by 17.8% during the first IVI and by 28.7% after 1 year of observation (p<0.001). ACD before treatment was statistically significantly higher in patients with IOL compared to patients of group 1 by an average of 39.3% (p<0.001). ACA from the nasal and temporal sides in the meridian 0°—180° before the start of treatment was statistically significantly wider in phakic patients than in the control group, by an average of 15.9±9.3° (p<0.001) and 16.9±8.2° (p<0.001), respectively. According to AS-OCT, there was no shift of the iris-lens diaphragm in patients with an IOL after multiple IVI of an anti-VEGF drug, in contrast to the control group.

CONCLUSIONS

AS-OCT was used to determine for the first time the changes in the parameters of the anterior chamber of the eye in patients with a natural and artificial lens after multiple injections of an anti-VEGF drug in the treatment of nAMD.

Keywords:

anti-VEGF drugs

intravitreal injection

intraocular pressure

anterior segment optical coherence tomography

Authors:

Andreeva Yu.S.

Krasnov Research Institute of Eye Diseases

ORCID: 0000-0001-8319-926X

Alkharki L.

Krasnov Research Institute of Eye Diseases

SPIN RSCI: 6489-3529
Scopus AuthorID: 57210715970
ORCID: 0000-0001-6791-4219

Budzinskaya M.V.

Krasnov Research Institute of Eye Diseases

SPIN RSCI: 3552-7061
Scopus AuthorID: 6508005851
ResearcherID: C-3026-2014
ORCID: 0000-0002-5507-8775

Received:

27.12.2023

Accepted:

11.02.2024

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