The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Arzhimatova G.Sh.

GBOU DPO "Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia" Minzdrava Rossii;
Oftal'mologicheskaia klinicheskaia bol'nitsa, filial #1 GKB im. S.P. Botkina Departamenta zdravookhraneniia

Hejlo T.S.

Center for Therapeutic ophthalmology Leninskij prospekt, d. 63/2, korp. 1, Moscow, Russian Federation, 119991

Novova N.L.

Center of therapeutic ophthalmology, 63/2, 1, Leninsky Pr., Moscow, Russian Federation, 119991

Suchkova O.V.

City clinical hospital named after S.P. Botkin, Branch №1, Mamonovskiy per., 7, Moscow, Russian Federation, 123001;
Center of therapeutic ophthalmology, 63/2, 1, Leninsky Pr., Moscow, Russian Federation, 119991;
Scientific Clinical Center of Russian Railways, 20 Chasovaya St., Moscow, Russian Federation, 125315

Bulbar capillaroscopy and plethysmography for assessment of blood microcirculation and endothelium properties in type 1 diabetes

Authors:

Arzhimatova G.Sh., Hejlo T.S., Novova N.L., Suchkova O.V.

More about the authors

Journal: Russian Annals of Ophthalmology. 2019;135(2): 55‑61

DOI: 10.17116/oftalma201913502155

Views: 1516

Downloaded: 62

Download PDF (RU)
Contact the author
Table of contents

BULBAR CAPILLAROSCOPY AND PLETHYSMOGRAPHY FOR ASSESSMENT OF BLOOD MICROCIRCULATION AND ENDOTHELIUM PROPERTIES IN TYPE 1 DIABETES
BULBAR CAPILLAROSCOPY AND PLETHYSMOGRAPHY FOR ASSESSMENT OF BLOOD MICROCIRCULATION AND ENDOTHELIUM PROPERTIES IN TYPE 1 DIABETES

To cite this article:

Arzhimatova GSh, Hejlo TS, Novova NL, Suchkova OV. Bulbar capillaroscopy and plethysmography for assessment of blood microcirculation and endothelium properties in type 1 diabetes. Russian Annals of Ophthalmology. 2019;135(2):55‑61. (In Russ.)
https://doi.org/10.17116/oftalma201913502155

Подписка 2025-2 (Russian Annals of Ophthalmology)
 
МСФ на ЯМ
Close metadata
Recommended articles:
Prevalence of diabetic reti­nopathy asse­ssed using two-field mydriatic fundus photography. Russian Annals of Ophthalmology. 2024;(4):60-67
Obje­ctive stru­ctural and functional moni­toring of poly­peptide reti­nal neuroprotective therapy in diabetic reti­nopathy. Russian Annals of Ophthalmology. 2024;(5):97-104
Diabetic reti­nopathy and pregnancy. Russian Annals of Ophthalmology. 2024;(6):145-151
The effect of vitrectomy on changes in mole­cular biomarker levels of the vitreous cavity in the early postoperative period in proliferative diabetic reti­nopathy. Russian Annals of Ophthalmology. 2025;(2):30-36
The effe­cts of intraoperative use of angiogenesis inhi­bitors on outcomes and complication rates in the surgical treatment of proliferative diabetic reti­nopathy. Russian Annals of Ophthalmology. 2025;(2):44-50
Clinical and meta­bolic features of neurocognitive testing in children and adolescents with type 1 diabetes mellitus. Russian Journal of Preventive Medi­cine. 2024;(8):60-65
Economic analysis of diabetes type 1 screening in children in the Russian Fede­ration. Medi­cal Technologies. Asse­ssment and Choice. 2024;(3):104-114
Diagnosis and treatment of erectile dysfunction in patients with type 1 diabetes mellitus. Rege­nerative Biotechnologies, Preventive, Digi­tal and Predictive Medi­cine. 2024;(3):5-10
Dyna­mics of arte­rial stiffness indi­cators during anti­hypertensive therapy. Russian Journal of Preventive Medi­cine. 2025;(2):74-79
A clinical case of diabulimia in type 1 diabetes mellitus: Psychopathological mechanisms and psychosomatic rela­tionships. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4):118-123

Purpose — to evaluate the properties of the microvasculature of bulbar conjunctiva and to assess the function of endothelium of the main arteries in type 1 diabetes mellitus (T1DM). Material and methods. The study included 35 patients with T1DM and initial nonproliferative diabetic retinopathy (NPDR). The control group consisted of 30 subjects. In addition to standard ophthalmic examination, all participants underwent digital bulbar capillaroscopy (DBC), pulse wave velocity (PWV) test, and plethysmography for assessment of endothelium function. Results. According to DBC, in comparison to the control group, diabetic patients with even initial NPDR had disturbances of blood microcirculation manifested as increased average venous vessel width (p=0.04), reduced arterial capillary blood flow (p=0.02), increased blood sludging (p=0.001), and increased duration of blood stasis (p=0.03). Evaluation of vessel endothelium in T1DM patients with NPDR showed increased PWV (p=0.03). Conclusion. Diabetic patients with NPDR showed marked changes of capillary blood flow alongside signs of endothelial dysfunction. The most significant change was increased venous vessel width.

Keywords:

type 1 diabetes mellitus
diabetic retinopathy
digital bulbar capillaroscopy
function of endothelium
pulse wave velocity

Authors:

Arzhimatova G.Sh.

GBOU DPO "Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia" Minzdrava Rossii;
Oftal'mologicheskaia klinicheskaia bol'nitsa, filial #1 GKB im. S.P. Botkina Departamenta zdravookhraneniia

Hejlo T.S.

Center for Therapeutic ophthalmology Leninskij prospekt, d. 63/2, korp. 1, Moscow, Russian Federation, 119991

Novova N.L.

Center of therapeutic ophthalmology, 63/2, 1, Leninsky Pr., Moscow, Russian Federation, 119991

Suchkova O.V.

City clinical hospital named after S.P. Botkin, Branch №1, Mamonovskiy per., 7, Moscow, Russian Federation, 123001;
Center of therapeutic ophthalmology, 63/2, 1, Leninsky Pr., Moscow, Russian Federation, 119991;
Scientific Clinical Center of Russian Railways, 20 Chasovaya St., Moscow, Russian Federation, 125315

List of references:

  1. Klein BE, Klein R, McBride PE. Cardiovascular disease, mortality, and retinal microvascular characteristics in type 1 diabetes: Wisconsin Epidemiologic Study of Diabetic Retinopathy. Arch Intern Med. 2004;164:1917-1924. https://doi.org/10.1001/archinte.164.17.1917
  2. Glycemic Targets. American Diabetes Association. Diabetes Care. 2015; 38(suppl 1):33-40.
  3. 10.2337/dc15-S009
  4. Bohlen HG. Microvascular Consequences of Obesity and Diabetes. Handbook of physiology Microcirculation. 2008;19:895-898. https://doi.org/10.1002/cphy.cp020419
  5. Garber AJ, Abrahamson MJ, Barzilay JI, Blonde L, Bloomgarden ZT, Bush MA. American Association of Clinical Endocrinologists’ Comprehensive Diabetes Management Algorithm 2013 Consensus Statement. Endocrine Practice. 2013;19(2):1-48. https://doi.org/10.4158/EP13176.CS
  6. Jin S, Noh C, Yang S, et al. Endothelial dysfunction and microvascular complications in type 1 diabetes mellitus. J Korean Med Sci. 2008;1:77-82. https://doi.org/10.3346/jkms.2008.23.1.77
  7. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001;414:813-820. https://doi.org/10.1038/414813a
  8. Lee MY, Wang Y, Vanhoutte PM. Senescence of cultured porcine coronary arterial endothelial cells is associated with accelerated oxidative stress and activation of NFkB. J Vasc Res. 2010;47:287-298. https://doi.org/10.1159/000265563
  9. Balabolkin MI. Rol’ glikirovaniya belkov, okisli- tel’nogo stressa v patogeneze sosudistyh oslozhneniĭ pri saharnom diabete. Saharnyi diabet. 2002;4(17):8-16. (In Russ.)
  10. Coutinho M, Gerstein HC, Wang Y, Yusuf S. The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years. Diabetes Care. 1999;22:233-240. https://doi.org/10.2337/diacare.22.2.233
  11. Sarwar N, Gao P, Seshasai SR, Gobin R, Kaptoge S, DiAngelantonio E, Ingelsson E, Lawlor DA, Selvin E, Stampfer M, Stehouwer CD, Lewington S, Pennells L, Thompson A, Sattar N, White IR, Ray KK, Danesh J. Diabetes mellitus, fasting blood glucose concentration and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet. 2010;375:2215-2222. https://doi.org/10.1016/S0140-6736(10)60484-9
  12. Cleary PA, Orchard TJ, Genuth S, Wong ND, Detrano R, Backlund JY, Zinman B, Jacobson A, Sun W, Lachin JM, Nathan DM. The effect of intensive glycemic treatment on coronary artery calcification in type 1 diabetic participants of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study. Diabetes. 2006;55:3556-3565. https://doi.org/10.2337/db06-0653
  13. Soedamah-Muthu SS, Colhoun HM, Abrahamian H, Chan NN, Mangili R, Reboldi GP, Fuller JH. Trends in hypertension management in Type I diabetes across Europe, 1989/1990—1997/1999. Diabetologia. 2002;45:1362-1371. https://doi.org/10.1007/s00125-002-0914-6
  14. Gurfinkel YuI, Makeeva OV, Ostrozhinsky VA. Features of microcirculation, endothelial function and the speed of the notebook PC pulse wave in patients with initial stages of hypertension. Funktsionalnaya diagnostika. 2010;2:17-24. (In Russ.)
  15. Gurfinkel YuI, Atkov OYu, Sasonko ML. New approach towards the integral assessments of cardiovascular status in patients with arterial hypertension. Rossiyskii kardiologicheskii zhurnal. 2014;1(105):101-106. (In Russ.)
  16. Aellen J, Dabiri A, Heim A. Preserved capillary density of dorsal finger skin in treated hypertensive patients with or without type 2 diabetes. Microcirculation. 2012;19:554-562. https://doi.org/10.1111/j.1549-8719.2012.00188.x
  17. Antonios T, Rattray FM, Singer DR, et al. Rarefaction of skin capillaries in normotensive offspring of individuals with essential hypertension. Heart. 2003;89(2):175-178. https://doi.org/10.1136/heart.89.2.175
  18. Bollinger A, Fagrell B. Clinical capillaroscopy. Hogrefe & Huber Publishers. 1990.
  19. Cutolo M, Grassi W, Cerenic MM. Raynaud’s phenomenon and the role of capillaroscopy. Arthritis Rheum. 2000;4B:3023-3030. https://doi.org/10.1002/art.11310
  20. Mishchenko NP, Fedoreyev SA, Dogadova LP. The drug histochrome for ophthalmology. Vest. DVO RAN. 2004;3:111-119. (In Russ.)
  21. Florea I, Stoica LE, Jolea I. Chronic venous insufficiency Clinical-Evolutional Aspects. Current Health Sciences Journal. 2011;37(1):21-25.
  22. Dormandy JA. Pathophysiology of venous leg ulceration: an update. Angio logy. 1997;48:71-75. https://doi.org/10.1177/000331979704800112
  23. Balas P, Pangratis N. The diagnostic investigation using vital capillary microscopy and dynamic capillaroscopy. Clinical Hemorheology and Microcirculation. 1997;17(5):371-383.
  24. Bonetti PO, Pumper GM, Higano ST. Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia. Cardiology. 2004;44:2137-2141. https://doi.org/10.1016/j.jacc.2004.08.062
  25. Skyler JS, Bergenstal R, Bonow RO, Buse J, Deedwania P, Gale EAM. Intensive glycemic control and the prevention of cardiovascular events: implications of the ACCORD, ADVANCE, and VA diabetes trials: a position statement of the American Diabetes Association and a scientific statement of the American College of Cardiology Foundation and the American Heart Association. Diabetes Care. 2008;32(1):187-192. https://doi.org/10.2337/dc08-9026
  26. Krutikov E.S., Zhitova V.A., Krutikova M.S. Izmenenie pokazatelej kapillyaroskopii u bol'nyh saharnym diabetom 1-go tipa pri razvitii hronicheskih oslozhnenij, Mezdunarodnyi endokrinologicheskij zhurnal. 2014;2(58):40-43. (In Russ.)
  27. Avogaro A, Calo L, Piaruli F, et al. Effect of acute ketosis on the endothelial function of type 1 diabetic patients: the rote of nitric oxide. Diabetes. 1999;48:391-397. https://doi.org/10.2337/diabetes.48.2.391
  28. The DECODE Study Group, the European Diabetes Epidemiology Group: Glucose tolerance and cardiovascular mortality: comparison of fasting and 2-hour diagnostic criteria. Arch Intern Med. 2001;61:397-405. https://doi.org/10.1001/archinte.161.3.397
  29. Edelstein SL, Knowler WC, Bain RP. Predictors of progression from impaired glucose tolerance to NIDDM: an analysis of six prospective studies. Diabetes. 1997;46:701-710. https://doi.org/10.2337/diab.46.4.701
  30. De Vriese AS, Verbeuren TJ, Vand V, Lameire NH and Vanhoutte PM. Endothelial dysfunction in diabetes. Br J Pharmacol. 2000;130:963-974. https://doi.org/10.1038/sj.bjp.0703393
  31. Schiekofer S, Balletshofer B, Andrassy M. Endothelial dysfunction in diabetes mellitus. Semin Thromb Hemost. 2000;26(5):503-511. https://doi.org/10.1055/s-2000-13206

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.