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Ismailova D.S.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva;
GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova" Minzdrava RF

Podgornaia N.N.

Kafedra glaznykh bolezneĭ Pervogo MGMU im. I.M. Sechenova;
FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

Corneal damage in patients with thyroid eye disease

Authors:

Ismailova D.S., Podgornaia N.N.

More about the authors

Journal: Russian Annals of Ophthalmology. 2015;131(5): 98‑103

DOI: 10.17116/oftalma2015131598-103

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CORNEAL DAMAGE IN PATIENTS WITH THYROID EYE DISEASE
CORNEAL DAMAGE IN PATIENTS WITH THYROID EYE DISEASE

To cite this article:

Ismailova DS, Podgornaia NN, Podgornaia NN. Corneal damage in patients with thyroid eye disease. Russian Annals of Ophthalmology. 2015;131(5):98‑103. (In Russ.)
https://doi.org/10.17116/oftalma2015131598-103

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

This is a review of literature on etiology, pathogenesis, risk factors, and treatment of thyroid-associated keratopathy. Both Russian and foreign sources have been thoroughly examined.

Keywords:

thyroid eye disease
corneal ulcer
dry eye syndrome
eyelid retraction
lagophthalmos
orbital decompression

Authors:

Ismailova D.S.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva;
GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova" Minzdrava RF

Podgornaia N.N.

Kafedra glaznykh bolezneĭ Pervogo MGMU im. I.M. Sechenova;
FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

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References:

  1. Brovkina A. Endokrinnaya oftalmopatia. Moscow: Geotar-Med; 2004. (In Russ.)
  2. Nowak M, Marek B, Kos-Kudła B, Kajdaniuk D, Siemińska L. Tear film profile in patients with active thyroid orbithopathy. Klin Oczna. 2005;107:479-482.
  3. Brovkina A, Aubakirova A, Moslekhi S. On differential diagnosis of clinical forms of oedematous exophtalmos. Rossiyskay pediatricheskaya oftal’mologia. 2008;3:9-11. (In Russ.)
  4. Ismailova DS, Fedorov AA, Grusha YO. Ocular surface changes in thyroid eye disease. Orbit. 2013;32(2):87-90.
  5. Grusha Y, Fedorov A, Ismailova D. Morphology of conjunctival changes in thyroid eye disease. Vestnik oftal'mologii. 2011;127(2):31-35. (In Russ.)
  6. Gilbard GP, Farris RL. Ocular surface drying and tear film osmolarity in thyroid eye disease. Acta ophthalmol. 1983;61(1):108-116. doi:10.1111/j.1755-3768.1983.tb01401.x
  7. Khurana AK, Sunder S, Ahluwalia BK, Malhotra KC. Tear film profile in Grave’s ophthalmopathy. Acta Ophthalmol (Copenh). 1992;70:346-349. doi:10.1111/j.1755-3768.1992.tb08576.x
  8. Eckstein AK, Finkenrath A, Heiligenhaus A, Renzing-Kohler K, Esser J, Krüger C, Quadbeck B, Steuhl KP, Gieseler RK. Dry eye syndrome in thyroid-associated ophthalmopathy: lacrimal expression of TSH receptor-specific autoantibodies. Acta Ophthalmol Scand. 2004;82:291-297. doi:10.1111/j.1395-3907.2004.00268.x
  9. Brovkina A, Panteleeva O. Prevention and treatment of dry eye syndrome in thyroid eye disease. Sindrom suhogo glaza. 2003;4:21-24. (In Russ.)
  10. Khalil HA, De Keizer RJ, Kiljstra A. Analysis of tear proteins in Graves’ ophthalmopathy by high-performance liquid chromatography. Am J Ophthalmol. 1988;106:186-190. doi:10.1016/0002-9394(88)90832-x
  11. Khalil HA, De Keizer RJ, Kiljstra A. Secretory IgA and Lysozyme in tears of patients with Graves’ ophthalmopathy. Doc Ophthalmol. 1989;72:329-334. doi:10.1007/bf00153500
  12. Brasil MV, Brasil OF, Vieira RP, Vaisman M, Amaral Filho OM. Tear film analysis and its relation with palpebral fissure height and exophthalmos in Graves' ophthalmopathy. Arq Bras Oftalmol. 2005;68(5):615-618.
  13. Grusha Y, Ismailova D, Gankovskaya О. Risk factors of corneal damage in patients with thyroid eye diseases. Vestnik oftal'mologii. 2010;126(6):35-38. (In Russ.)
  14. Chaly Y, Paleolog E, Kolesnikova T, Tikhonov I, Petratchenko E, Voitenok N. Human neutrophil α-defensin modulates cytokine production in human monocytes and adhesion molecules expression in endothelial cells. Eur Cytokine Netw. 2000;11:257-266.
  15. Wells JR, Michelson MA. Diagnosing and Treating Neurotrophic keratopathy. Ophthalmic Pearls. Available at: www.aao.org.
  16. Polyanskaya N. Treatment of patients with corneal ulcer associated with severe somatic state. Rousskiy meditsinskiy zhournal. Klinicheskaya oftal’mologiya. 2007;8(1):14-16. (In Russ.)
  17. Heinz C, Eckstein A, Steuhl KP, Meller D. Amniotic membrane transplantation for reconstruction of corneal ulcer in graves ophthalmopathy. Cornea. 2004;23(5):524-526. doi:10.1097/01.ico.0000114128.63670.e2
  18. Solomon A, Meller D, Prabhasawat P, John T, Espana EM, Steuhl KP, Tseng SC. Amniotic membrane grafts for nontraumatic corneal perforations, descemetoceles, and deep ulcers. Ophthalmology. 2002;109(4):694-703. doi:10.1016/s0161-6420(01)01032-6
  19. Grusha Y, Kasparov A, Kiseleva T, Fedorov A, Filimonov G, Zaytsev A, Polunina A, Ismailova D. Combined surgical treatment of corneal ulcer in endocrine ophthalmopathy. Vestnik oftal'mologii. 2008;124(6):57-59. (In Russ.)
  20. Della Rocca R. Thyroid-related orbithopathy: concepts and management. Facial Plast Surg. 2007;23:168-173. doi:10.1055/s-2007-984556
  21. Guy JB Simon, Ahmad M Mansury Schwarcz RM, Lee S, McCann JD, Goldberg RA. Simultaneous orbital decompression and correction of upper eyelid retraction versus staged procedures in thyroid-related orbitopathy. Ophthalmology. 2005;112(5):923-932. doi:10.1016/j.ophtha.2004.12.028
  22. Adams GGW, Kirkness CM, Lee JP. Botulinum toxin A-induced ptosis in corneal disease. Eye. 1987;1:603-608. doi:10.1038/eye.1987.93
  23. Ellis MF, Daniell M. An evaluation of the safety and efficacy of Botulinum toxin type A (Botox) when used to produce a protective ptosis. Clin Exp Ophthalmol. 2001;29(6):394-399. doi:10.1046/j.1442-9071.2001.d01-28.x
  24. Naik MN, Gangopadhyay N, Fernandes M, Murthy R, Honavar SG. Anterior hemodenervation of levator palpebrae superioris with Botulinum toxin type-A (Botox) to induce temporary ptosis for corneal protection. Eye. 2008;22(9):1132-1136. doi:10.1038/sj.eye.6702866
  25. Scott AB. Injection treatment of endocrine orbital myopathy. Doc Ophthalmol. 1984;58:141-145. doi:10.1007/bf00140912
  26. Ozkan SB, Can D, Söylev MF, Arsan AK, Duman S. Chemodenervation in treatment of upper eye lid retraction. Ophthalmology. 1997;211:387-390. doi:10.1159/000310837
  27. Uddin JM, Davies PD. Treatment of upper eye lid retraction associated with thyroid eye disease with subconjunctival botulinum toxin injection. Ophthalmology. 2002;108:1183-1187. doi:10.1016/s0161-6420(02)01041-2
  28. Ebner R. Botulinum toxin type A in upper eye lid retraction of Graves’ ophthalmopathy. J Clin Neuroophthalmol. 1993;13:258-260.
  29. Biglan AW. Control of eye lid retraction associated with Graves’ disease with botulinum A toxin. Ophthal Surg. 1994;25:186-188. doi:10.1097/00002341-199503000-00026
  30. Morgenstern KE, Evanchan J, Foster JA, Cahill KV, Burns JA, Holck DE, Perry JD, Wulc AE. Botulinum toxin type A for dysthyroid upper eye lid retraction. Ophthal Plast Reconstr Surg. 2004;20(3):181-185. doi:10.1097/00002341-200405000-00001
  31. Costa PG, Saraiva FP, Pereira IC, Monteiro ML, Matayoshi S. Comparative study of Botox injection of upper eye lid retraction with 6-month follow up in patients with thyroid eye disease in congestive or fibrotic stage. Eye. 2008;1:1-7. doi:10.1038/eye.2008.165
  32. Shin M-J, Liao S-L, Lu H-Y. A single transcutaneous injection with Botox for dysthyroid lid retraction. Eye. 2004;18:466-469. doi:10.1038/sj.eye.6700690
  33. Grusha Y, Ismailova D, Ivanchenko Iu. The first experience in using the stabilized gyaluronic acid preparation to correct lagophthalmos. Vestnik oftal'mologii. 2010;126(1):39-42. (In Russ.)
  34. Pakarinen M, Tervo T, Tarkkanen A. Tarsorraphy in the treatment of persistent corneal lesions. Acta Ophthalmol Suppl. 1987;182:69-73. doi:10.1111/j.1755-3768.1987.tb02595.x
  35. Luo QL, Tang L, He WM. Clinical investigation of tarsorrhaphy suture for treatment thyroid-associated ophthalmopathy. Zhonghua Yan Ke Za Shi. 2005;41(9):777-780.
  36. Cosar CB, Cohen EJ, Rapuano CJ, Maus M, Penne RP, Flanagan JC, Laibson PR. Tarsorrhaphy: clinical experience from a cornea practice. Cornea. 2001;20(8):187-791. doi:10.1097/00003226-200111000-00002
  37. Donnenfeild ED, Perry HD, Nelson DB. Cyanoacrylate temporary tarsorrhaphy in the management of corneal epithelial defects. Ophthalmic Surg. 1991;22:591-593.
  38. Mourits MP, Sasim I. A single technique to correct various degrees of upper lid retraction in patients with Graves' orbitopathy. Br J Ophthalmol. 1999;83(1):81-84. doi:10.1136/bjo.83.1.81
  39. Adams GGW, Kirkness CM, Lee JP. Botulinum toxin A-induced ptosis in corneal disease. Eye. 1987;1:603-608. doi:10.1038/eye.1987.93
  40. Ellis MF, Daniell M. An evaluation of the safety and efficacy of Botulinum toxin type A (Botox) when used to produce a protective ptosis. Clin Exp Ophthalmol. 2001;29(6):394-399. doi:10.1046/j.1442-9071.2001.d01-28.x
  41. Crawford JS. Correction of upper eye lid retraction using tissue removed in blepharoptosis repair. 1986;101:600-604. doi:10.1016/0002-9394(86)90952-9
  42. Soares EJC, Franka VP. Lengthening of the upper eye lid retractors. Orbit. 1991;10:133-140. doi:10.3109/01676839109087656
  43. Piggott TA, Nazi ZBM, Hodgkinson PD. New technique of levator lengthening for the retracted upper eyelid. Br J Plast Surg. 1995;48:127-131. doi:10.1016/0007-1226(95)90143-4
  44. Tallstedt L. Surgical treatment of thyroid eye disease. Thyroid. 1998;8:447-452. doi:10.1089/thy.1998.8.447
  45. Buffman FV, Rootman J. Upper lid retraction: its diagnosis and treatment. Int Ophthalmol Clin. 1978;18:75-86. doi:10.1097/00004397-197823000-00006
  46. Putterman AM, Urist M. Surgical treatment of upper eyelid retraction. Arch Ophthalmol. 1972;87;401-405. doi:10.1001/archopht.1972.01000020403007
  47. Harvey JT, Corin S, Nixon D, Veloudios A. Modified levator aponeurosis recession for upper eyelid retraction in Graves’ disease. Ophthalmic Surg. 1991;22:313-317. doi:10.1097/00002341-199209000-00015
  48. Kohn R. Treatment of eyelid retraction with two pedicle tarsal rotation flaps. Am J Ophthalmol. 1983;95:539-544. doi:10.1016/0002-9394(83)90278-7
  49. Elner VM, Hassan AS, Frueh BR. Graded full-thickness anterior blepharotomy for upper eyelid retraction. Arch Ophthalmol. 2004;122:55-60. doi:10.1001/archopht.122.1.55
  50. Baldeschi L, Wakelkamp IMMJ, Lindeboom R, Prummel MF, Wiersinga WW. Early versus late orbital decompression a retrospective study in 125 patients. Ophthalmology. 2006;113:874-878. doi:10.1016/j.ophtha.2005.10.060
  51. Goldberg RA, Shorr N, Cohen MS. The medial orbital strut in the prevention of postdecompression dystopia in dysthyroid ophthalmopathy. Ophthal Plast Reconstr Surg. 1992;8:32-34. doi:10.1097/00002341-199203000-00005
  52. Olver JM, Rose GE, Khaw, Collin JR. Correction of lower eyelid retraction in thyroid eye disease: a randomized controlled trial of retractor tenotomy with adjuvant antimetabolite versus scleral graft. Br J Ophthalmol. 1998;82:174-180. doi:10.1136/bjo.82.2.174
  53. Jordan DR, Anderson RL. The lateral tarsal strip revisited. The enhanced tarsal strip. Arch Ophthalmol. 1989;107:604-606. doi:10.1001/archopht.1989.01070010618042
  54. Holds JB, Anderson RL, Thiese SM. Lower eyelid retraction: a minimal incision surgical approach to retractor lysis. Ophthalmic Surg. 1990;21:767-771. doi:10.1097/00002341-199112000-00012
  55. Dryden RM, Soll DB. The use of scleral transplantation in cicatricial entropion and eyelid retraction. Trans Am Acad Ophthalmol Otolaryngol. 1977:83:669-676.
  56. Obear MF, Smith B. Tarsal grafting to elevate the lower lid margin. Am J Ophthalmol. 1965;59:1088. doi:10.1016/0002-9394(65)93428-8
  57. Tessier P. Secondary treatment of the injured and mutilated eyelid. In: Tessier P, Callahan J, Mustarde J et al., eds. Symposium on Plastic Surgery in the Orbital Region. St. Louis: Mosby; 1976;12:57.
  58. Stephenson CM, Brown BZ. The use of tarsus as a free autogenous graft in eyelid surgery. Ophthal Plast Reconstr Surg. 1985;1:43-50. doi:10.1097/00002341-198501000-00007
  59. Siegel RJ. Palatal grafts for eyelid reconstruction. Plast Reconstruct Surg. 1985;76:411-416. doi:10.1097/00006534-198509000-00013
  60. Acikel C, Celicoz B, Yildiz TF. Y-shaped hard palate mucoperiostea graft and V-Y advancement flap in a reconstruction of a combined defect involving lateral canthus and upper and lower eye lids. Ann Plast Surg. 2004;52:97-101. doi:10.1097/01.sap.0000070432.99658.db
  61. Kim JW, Kikkava DO, Lemke BN. Donor site complications of head palate mucosal grafting. Ophthal Plast Reconstr Surg. 1997;13:36-39. doi:10.1097/00002341-199703000-00007
  62. Wearne MJ, Sandy C, Rose GE, Pitts J, Collin JRO. Autogenous hard palate mucosa: the ideal lower eyelid spacer? Br J Ophthalmol. 2001;85:1183-1187. doi:10.1136/bjo.85.10.1183
  63. Tan J, Olver L, Wright M, Maini R, Neoh C, Dickinson AJ. The use of porous polyethylene (Medpror) lower eyelid spacers in lid lengthening and stabilization. Br J Ophthalmol. 2004;88:1197-1200. doi:10.1136/bjo.2003.029397
  64. Aldave AJ, Maus M, Rubim PA. Advances in the management of lower eyelid retraction. Facial Plast Surg. 1999;15:213-224. doi:10.1055/s-2008-1064321
  65. Jong-Hesse Y, Paridaens DA. Korrektur von Unterlidretraction mittels eines porösen polyethylene (Medpror) Unterlidtransplantats. Klin Monatsbl Augenheilkd. 2006;223;577-582. doi:10.1055/s-2006-926508
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