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Mikhaĭlova M.A.

Kafedra glaznykh bolezneĭ GBOU VPO "Pervyĭ MGMU im. I.M. Sechenova"

Sizova M.V.

FGBU "NII glaznykh bolezneĭ" RAMN

Shelankova A.V.

FGBU "NII glaznykh bolezneĭ" RAMN

Pathogenesis of retinal vein occlusions

Authors:

Mikhaĭlova M.A., Sizova M.V., Shelankova A.V.

More about the authors

Journal: Russian Annals of Ophthalmology. 2014;130(2): 88‑92

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Table of contents

PATHOGENESIS OF RETINAL VEIN OCCLUSIONS
PATHOGENESIS OF RETINAL VEIN OCCLUSIONS

To cite this article:

Mikhaĭlova MA, Sizova MV, Shelankova AV. Pathogenesis of retinal vein occlusions. Russian Annals of Ophthalmology. 2014;130(2):88‑92. (In Russ.)

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
 
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Abstract:

Retinal vein occlusion (RVO) is a multifactorial disease and its pathogenesis is still not fully understood. Mechanical, hemodynamic, rheological, coagulation, biochemical, and immunological factors are involved. Two currently prevalent theories of RVO pathogenesis are the mechanical theory and the "coagulopathic" theory. The latter implies an imbalance between thrombogenic factors and antithrombogenic protection. According to some authors, endothelial dysfunction plays a large part in thrombosis development, neoangiogenesis, vascular remodeling, intravascular activation of platelets and leucocytes. In recent studies increasing emphasis is being placed on investigation of immune-mediated mechanisms of vein occlusions. RVO can also be associated with combined hypoxic and free radical tissue damage.

Keywords:

retinal vein occlusion
endothelial dysfunction
free radicals
hypoxia
retinal vein occlusion
endothelial dysfunction
free radicals
hypoxia

Authors:

Mikhaĭlova M.A.

Kafedra glaznykh bolezneĭ GBOU VPO "Pervyĭ MGMU im. I.M. Sechenova"

Sizova M.V.

FGBU "NII glaznykh bolezneĭ" RAMN

Shelankova A.V.

FGBU "NII glaznykh bolezneĭ" RAMN

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References:

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