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Budzinskaya M.V.

FGBU "Nauchno-issledovatel'skiĭ institut glaznykh bolezneĭ" RAMN, Moskva

Pogoda T.V.

Research Center of Neurology, Moscow, Russia

Generozov E.V.

Sechenov First Moscow State Medical University of Healthcare Ministry of the Russia, Moscow, Russia, Federal Research Clinical Center for Physico-Chemical Medicine, FMBA of Russia, Moscow, Russia

Chikun E.A.

FGBU "Nauchno-issledovatel'skiĭ institut glaznykh bolezneĭ" RAMN, Moskva

Gurova I.V.

FGBU "Nauchno-issledovatel'skiĭ institut glaznykh bolezneĭ" RAMN, Moskva

Shchegoleva I.V.

FGBU "Nauchno-issledovatel'skiĭ institut glaznykh bolezneĭ" RAMN, Moskva

Sizova M.V.

FGBU "NII glaznykh bolezneĭ" RAMN

Contemporary pharmacogenetic approaches to the treatment of age-related macular degeneration

Authors:

Budzinskaya M.V., Pogoda T.V., Generozov E.V., Chikun E.A., Gurova I.V., Shchegoleva I.V., Sizova M.V.

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Journal: Russian Annals of Ophthalmology. 2013;129(5): 127‑135

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Table of contents

CONTEMPORARY PHARMACOGENETIC APPROACHES TO THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION
CONTEMPORARY PHARMACOGENETIC APPROACHES TO THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION

To cite this article:

Budzinskaya MV, Pogoda TV, Generozov EV, Chikun EA, Gurova IV, Shchegoleva IV, Sizova MV. Contemporary pharmacogenetic approaches to the treatment of age-related macular degeneration. Russian Annals of Ophthalmology. 2013;129(5):127‑135. (In Russ.)

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

A study on the role of CFH, HTRA and IL-8 gene polymorphism in age-related macular degeneration (AMD) development has been conducted. At the first stage of the study genetic testing was done in 69 patients with exudative AMD and 370 random Moscow citizens without the disease. The goal of the second stage was to determine the influence of gene polymorphism on patient's response to endovitreal ranibizumab treatment. For that, visual acuity and foveal thickness were assessed before and after ranibizumab injections in 120 patients with wet AMD. All patients were genotyped for the genes of interest. The results showed that the presence of homozygous 402H polymorphism in CFH gene, as well as homozygous (-625)A mutation in HTRA1 gene, determines certain clinical presentations. Moreover, visual acuity below 0.1 and presence of 402H, (-625)A and (-251)A alleles in both copies of all three genes (CFH, HTRA and IL-8) are negative predictors of disease severity and antiangiogenic treatment response.

Keywords:

age-related macular degeneration
CFH
HTRA1
pharmacogenetics
ranibizumab

Authors:

Budzinskaya M.V.

FGBU "Nauchno-issledovatel'skiĭ institut glaznykh bolezneĭ" RAMN, Moskva

Pogoda T.V.

Research Center of Neurology, Moscow, Russia

Generozov E.V.

Sechenov First Moscow State Medical University of Healthcare Ministry of the Russia, Moscow, Russia, Federal Research Clinical Center for Physico-Chemical Medicine, FMBA of Russia, Moscow, Russia

Chikun E.A.

FGBU "Nauchno-issledovatel'skiĭ institut glaznykh bolezneĭ" RAMN, Moskva

Gurova I.V.

FGBU "Nauchno-issledovatel'skiĭ institut glaznykh bolezneĭ" RAMN, Moskva

Shchegoleva I.V.

FGBU "Nauchno-issledovatel'skiĭ institut glaznykh bolezneĭ" RAMN, Moskva

Sizova M.V.

FGBU "NII glaznykh bolezneĭ" RAMN

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References:

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