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Kolesnikova L.I.

FGBU "Nauchnyĭ tsentr problem zdorov'ia sem'i i reproduktsii cheloveka" Sibirskogo otdeleniia RAMN, Irkutsk

Semenova N.V.

FGBU "Nauchnyĭ tsentr problem zdorov'ia sem'i i reproduktsii cheloveka" Sibirskogo otdeleniia RAMN, Irkutsk

Solodova E.I.

FGBU "Nauchnyĭ tsentr problem zdorov'ia sem'i i reproduktsii cheloveka" Sibirskogo otdeleniia RAMN, Irkutsk

Madaeva I.M.

FGBU "Nauchnyĭ tsentr problem zdorov'ia sem'i i reproduktsii cheloveka" Sibirskogo otdeleniia RAMN, Irkutsk

Oxidative stress in women with insomnia in different stages of menopause

Authors:

Kolesnikova L.I., Semenova N.V., Solodova E.I., Madaeva I.M.

More about the authors

Journal: Therapeutic Archive. 2017;89(8): 50‑56

DOI: 10.17116/terarkh201789850-56

Read: 3160 times

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Table of contents

OXIDATIVE STRESS IN WOMEN WITH INSOMNIA IN DIFFERENT STAGES OF MENOPAUSE
OXIDATIVE STRESS IN WOMEN WITH INSOMNIA IN DIFFERENT STAGES OF MENOPAUSE

To cite this article:

Kolesnikova LI, Semenova NV, Solodova EI, Madaeva IM. Oxidative stress in women with insomnia in different stages of menopause. Therapeutic Archive. 2017;89(8):50‑56. (In Russ.)
https://doi.org/10.17116/terarkh201789850-56

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Abstract:

Aim. To investigate of a lipid peroxidation (LPO) process and the antioxidant defense system (ADS) in peri- and postmenopausal women with insomnia. Subjects and methods. 47 perimenopausal women and 71 postmenopausal ones were examined. Each group was divided into 2 subgroups: 1) individuals with insomnia and 2) controls. LPO-ADS spectrophotometric studies were used in the investigation. Results. There was an increase in the serum levels of ketodienes and conjugated trienes and a decrease in those of α-tocopherol and retinol in postmenopause versus in perimenopause. In insomnia, there was a rise in the level of ketodienes and conjugated trienes in perimenopause; LPO substrates with conjugated double bonds, diene conjugates, and thiobarbituric acid-active products in postmenopause. The indicators of ADS do not differ from those in the controls. The integral indicator of oxidative stress assessment suggests that there is a LPO-ADS imbalance in the menopausal women with insomnia, which is most pronounced in postmenopause. Conclusion. The findings suggest that the patients with insomnia develop oxidative stress that is more marked in postmenopause.

Keywords:

lipid peroxidation
antioxidant defense
insomnia
perimenopause
postmenopause

Authors:

Kolesnikova L.I.

FGBU "Nauchnyĭ tsentr problem zdorov'ia sem'i i reproduktsii cheloveka" Sibirskogo otdeleniia RAMN, Irkutsk

Semenova N.V.

FGBU "Nauchnyĭ tsentr problem zdorov'ia sem'i i reproduktsii cheloveka" Sibirskogo otdeleniia RAMN, Irkutsk

Solodova E.I.

FGBU "Nauchnyĭ tsentr problem zdorov'ia sem'i i reproduktsii cheloveka" Sibirskogo otdeleniia RAMN, Irkutsk

Madaeva I.M.

FGBU "Nauchnyĭ tsentr problem zdorov'ia sem'i i reproduktsii cheloveka" Sibirskogo otdeleniia RAMN, Irkutsk

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