The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Budnevsky A.V.

N.N. Burdenko Voronezh State Medical University, Ministry of Health of the Russia, Voronezh, Russia

Ovsyannikov E.S.

N.N. Burdenko Voronezh State Medical University, Ministry of Health of the Russia, Voronezh, Russia

Rezova N.V.

N.N. Burdenko Voronezh State Medical University, Ministry of Health of Russia, Voronezh, Russia

Shkatova Ya.S.

N.N. Burdenko Voronezh State Medical University, Ministry of Health of Russia, Voronezh, Russia

Melatonin and hypertension: a possible role in combination therapy

Authors:

Budnevsky A.V., Ovsyannikov E.S., Rezova N.V., Shkatova Ya.S.

More about the authors

Journal: Therapeutic Archive. 2017;89(12): 122‑126

DOI: 10.17116/terarkh20178912122-126

Read: 18781 times

Download PDF (RU)
Contact the author
Table of contents

MELATONIN AND HYPERTENSION: A POSSIBLE ROLE IN COMBINATION THERAPY
MELATONIN AND HYPERTENSION: A POSSIBLE ROLE IN COMBINATION THERAPY

To cite this article:

Budnevsky AV, Ovsyannikov ES, Rezova NV, Shkatova YaS. Melatonin and hypertension: a possible role in combination therapy. Therapeutic Archive. 2017;89(12):122‑126. (In Russ.)
https://doi.org/10.17116/terarkh20178912122-126

МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Effi­cacy and tole­rability of azilsartan combined with amlo­dipine and amlo­dipine mono­therapy and combinations of amlo­dipine with other angiotensin II rece­ptor blockers. Russian Cardiology Bulletin. 2024;(4-2):161-171
Surgical treatment of intramedullary spinal cord tumors: a systematic review. Burdenko's Journal of Neurosurgery. 2025;(1):103-108
Risk factors and adve­rse outcomes of cardiovascular diseases in people with high normal blood pressure of the Ryazan region. (5-year prospective follow-up). Russian Journal of Preventive Medi­cine. 2025;(2):31-37
Modern methods of correction of age-related changes in the female body. Plastic Surgery and Aesthetic Medi­cine. 2025;(1):90-96
Diagnostics of hype­rtensive diso­rders in cardio-obstetrics: current state-of-affairs. Russian Journal of Human Reproduction. 2025;(1):63-77
Epidemiology of M. geni­talium infe­ction. What is known?. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(2):143-152
Study of the levo­carnitine effi­cacy for the treatment of mode­rate cognitive impairment in patients with hype­rtension. Russian Journal of Preventive Medi­cine. 2025;(4):45-50
Angiotensin model as a new approach to study of mese­nchymal stem cell sene­scence. Russian Cardiology Bulletin. 2025;(2):20-26
Chro­nic obstructive pulmonary disease (COPD 2024). Clinical guidelines (short version). Journal of Respiratory Medi­cine. 2025;(2):5-16
Septum orbi­tale as a key element in lower blepharoplasty: evolution from classic to tissue-sparing techniques. Plastic Surgery and Aesthetic Medi­cine. 2025;(2-2):96-102
Abstract:

This literature review gives the results of clinical trials studying the association of the level of endogenous melatonin and blood pressure (BP), the effects of exogenous melatonin on BP (particularly at night) in relation to the used rapid- or controlled-release formulation of melatonin.

Keywords:

melatonin
hypertension
review

Authors:

Budnevsky A.V.

N.N. Burdenko Voronezh State Medical University, Ministry of Health of the Russia, Voronezh, Russia

Ovsyannikov E.S.

N.N. Burdenko Voronezh State Medical University, Ministry of Health of the Russia, Voronezh, Russia

Rezova N.V.

N.N. Burdenko Voronezh State Medical University, Ministry of Health of Russia, Voronezh, Russia

Shkatova Ya.S.

N.N. Burdenko Voronezh State Medical University, Ministry of Health of Russia, Voronezh, Russia

Close metadata

References:

  1. Chazova IE, Ratova LG, Boytsov SA, et al. Diagnostics and treatment of arterial hypertension. Recommendations of the Russian medical society about an arterial hypertension and All-Russian science foundation of cardiologists. Sistemnye gipertenzii. 2010;3:5-26. (In Russ.)
  2. Cuspidi C, Meani S, Salerno M, et al. Cardiovascular target organ damage in essential hypertensives with or without reproducible nocturnal fall in blood pressure. J Hypertens. 2004;22(11):273-280. https://doi.org/10.1097/00004872-200402000-00010
  3. Fagard RH, Thijs L, Staessen JA at al. Night-day blood pressure ratio and dipping pattern as predictors of death and cardiovascular events in hypertension. J Hum Hypertens. 2009;23(10):645-653. https://doi.org/10.1038/jhh.2009.9
  4. Dolan E, Stanton A, Thijs L, et al. Superiority of ambulatory over clinic blood pressure measurement in predicting mortality: the Dublin outcome study. Hypertension. 2006;46(1):156-161. https://doi.org/10.1161/01.hyp.0000170138.56903.7a
  5. Komarov FI, Rapoport SI, Malinovskaya NK, et al. Melatonin is normal and pathology. Moscow: 2004; 308. (In Russ.)
  6. Sewerynek E. Melatonin and the cardiovascular system. Neuro Endocrinol Lett. 2002;Suppl.23:79-83.
  7. Cagnacci A, Arangino S, Angiolucci M, Maschio E, Longu G, Melis G. Potentially beneficial cardiovascular effects of melatonin administration in women. J Pineal Res. 1997;22(1):16-19. https://doi.org/10.1111/j.1600-079x.1997.tb00297.x
  8. Arangino S, Cagnacci A, Angiolucci M, et al. Effects of melatonin on vascular reactivity, catecholamine levels and blood pressure in healthy men. Am J Cardiol. 1999;83(9):1417-1419. https://doi.org/10.1016/s0002-9149(99)00112-5
  9. Cagnacci A, Arangino S, Angiolucci M, Maschio E, Melis GB. Influences of melatonin administration on the circulation of women. Am J Physiol. 1998;274(2 Pt 2):335-338.
  10. Gonzalez Rodriguez E, Hernandez A, Dibner C. Arterial blood pressure circadian rhythm: significance and clinical implications. Rev Med Suisse. 2012;8(353):1709-1714.
  11. Jonas M, Garfinkel D, Zisapel N, Laudon M, Grossman E. Impaired nocturnal melatonin secretion in non-dipper hypertensive patients. Blood Press. 2003;12(1):19-24. https://doi.org/10.1097/00004872-200006001-00120
  12. Zeman M, Dulkova K, Bada V, Herichova I. Plasma melatonin concentrations in hypertensive patients with the dipping and non-dipping blood pressure profile. Life Sci. 2005;76(16):1795-1803. https://doi.org/10.1016/j.lfs.2004.08.034
  13. Brugger P, Markti W, Herold M. Impaired nocturnal secretion of melatonin in coronary heart disease. Lancet. 1995;345(8962):1408. https://doi.org/10.1016/s0140-6736(95)92600-3
  14. Sakotnik A, Liebmann PM, Stoschitzky K, et al. Decreased melatonin synthesis in patients with coronary artery disease. Eur Heart J. 1999;20(18):1314-1317. https://doi.org/10.1053/euhj.1999.1527
  15. Cagnacci A, Arangino S, Angiolucci M, Maschio E, Longu G, Melis G. Potentially beneficial cardiovascular effects of melatonin administration in women. J Pineal Res. 1997;22(1):16-19. https://doi.org/10.1111/j.1600-079x.1997.tb00297.x
  16. Ray CA. Melatonin attenuates sympathetic nerve responses to orthostatic stress in humans. J Physiol. 2003;15:555(Pt 3):1043-1048. https://doi.org/10.1113/jphysiol.2003.043182
  17. Pickering TG. The clinical significance of diurnal blood pressure variations. Dippers and nondippers. Circulation. 1990;81(2):700-702. https://doi.org/10.1161/01.cir.81.2.700
  18. Hojo Y, Noma S, Ohki T, Nakajima H, Satoh Y. Autonomic nervous system activity in essential hypertension: A comparison between dippers and non-dippers. J Hum Hypertens. 1997;11(10):665-671. https://doi.org/10.1038/sj.jhh.1000515
  19. van der Zwan LP, Scheffer PG, Teerlink T. Reduction of myeloperoxidase activity by melatonin and pycnogenol may contribute to their blood pressure lowering effect. Hypertension. 2010; 56(3):e34. https://doi.org/10.1161/hypertensionaha.110.158170
  20. Kostovski E, Dahm AE, Iversen N, et al. Melatonin stimulates release of tissue factor pathway inhibitor from the vascular endothelium. Blood Coagul Fibrinolysis. 2011;22(4):254-259. https://doi.org/10.1097/mbc.0b013e3283442ce2
  21. Mattace-Raso FU, Hofman A, Verwoert GC, et al. Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: Establishing normal and reference values. Eur Heart J. 2010;31(19):2338-2350. https://doi.org/10.1093/eurheartj/ehq165
  22. Silva JA, Barbosa L, Bertoquini S, Maldonado J, Polonia J. Relationship between aortic stiffness and cardiovascular risk factors in a population of normotensives, white-coat normotensives, white-coat hypertensives, sustained hypertensives and diabetic patients. Rev Port Cardiol. 2004;23(12):1533-1547.
  23. Syrseloudis D, Tsioufis C, Andrikou I, et al. Association of nighttime hypertension with central arterial stiffness and urinary albumin excretion in dipper hypertensive subjects. Hypertens Res. 2011;34(1):120-125. https://doi.org/10.1038/hr.2010.192
  24. Yildiz M, Akdemir O. Assessment of the effects of physiological release of melatonin on arterial distensibility and blood pressure. Cardiol Young. 2009;19(2):198-203. https://doi.org/10.1017/s1047951109003692
  25. Yildiz M, Sahin B, Sahin A. Acute effects of oral melatonin administration on arterial distensibility, as determined by carotid-femoral pulse wave velocity, in healthy young men. Exp Clin Cardiol. 2006; 11(4):311-313.
  26. Le Bars D, Thivolle P, Vitte PA, et al. PET and plasma pharmacokineic studies after bolus intraenous administration of [11 c] melatonin in humans. Int J Radiat Appl Instrum. 1991;18(3):357-362.
  27. Waldhauser F, Waldhauser M, Lieberman HR, Deng MH, Lynch HJ, Wurtman RJ. Bioavailability of oral melatonin in humans. Neuroendocrinology. 2008;39(4):307-313. https://doi.org/10.1159/000123997
  28. Aldhous M, Franey C, Wright J, Arendt J. Plasma concentrations of melatonin in man following oral absorption of different preparations. Br J Clin Pharmacol. 1985;19(4):517-521. https://doi.org/10.1111/j.1365-2125.1985.tb02679.x
  29. Rachmani R, Shenhav G, Slavachevsky I, Levy Z, Ravid M. Use of a mild sedative helps to identify true non-dippers by ABPM: A study in patients with diabetes mellitus and hypertension. Blood Press Monit. 2004;9(2):65-69. https://doi.org/10.1097/00126097-200404000-00002
  30. McCann CC, Quera-Salva MA, Boudet J, et al. Effect of zolpidem during sleep on ventilation and cardiovascular variables in normal subjects. Fundam Clin Pharmacol. 1993;7(6):305-310. https://doi.org/10.1111/j.1472-8206.1993.tb00244.x
  31. Stergiou GS, Vemmos KN, Pliarchopoulou KM, Synetos AG, Roussias LG, Mountokalakis TD. Parallel morning and evening surge in stroke onset, blood pressure, and physical activity. Stroke. 2002;33(6): 1480-1486. https://doi.org/10.1161/01.str.0000016971.48972.14
  32. Obayashi K, Saeki K, Tone N et al. Relationship between melatonin secretion and nighttime blood pressure in elderly individuals with and without antihypertensive treatment: a cross-sectional study of the HEIJO-KYO cohort. Hypertens Res. 2014 Oct;37(10): 908-913. https://doi.org/10.1038/hr.2014.99
  33. Obayashi K, Saeki K, Kurumatani N. Asymmetric dimethylarginine attenuates the association of melatonin secretion with night-time blood pressure and dipping in elderly individuals. Circ J. 2014;78(12):2908-2914. https://doi.org/10.1253/circj.cj-14-0613
  34. Forman JP, Curhan GC, Schernhammer ES. Urinary melatonin and risk of incident hypertension among young women. J Hypertens. 2010 Mar;28(3):446-451. https://doi.org/10.1097/hjh.0b013e3283340c16
  35. Cui HW, Zhang ZX, Gao MT et al. Circadian rhythm of melatonin and blood pressure changes in patients with essential hypertension. Zhonghua Xin Xue Guan Bing Za Zhi. 2008;36(1):20-23.
  36. Cavallo A, Daniels SR, Dolan LM, Khoury JC, Bean JA. Blood pressure response to melatonin in type 1 diabetes. Pediatr Diabetes. 2004;5(1): 26-31. https://doi.org/10.1111/j.1399-543x.2004.00031.x
  37. Scheer FA, Van Montfrans GA, van Someren EJ, Mairuhu G, Buijs RM. Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension. Hypertension. 2004; 43(2):192-197. https://doi.org/10.1161/01.hyp.0000113293.15186.3b
  38. Lusardi P, Piazza E, Fogari R. Cardiovascular effects of melatonin in hypertensive patients well controlled by nifedipine: A 24-hour study. Br J Clin Pharmacol. 2000;49(5):423-427. https://doi.org/10.1046/j.1365-2125.2000.00195.x
  39. Grossman E, Laudon M, Yalcin R, et al. Melatonin reduces night blood pressure in patients with nocturnal hypertension. Am J Med. 2006;119(10):898-902. https://doi.org/10.1016/j.amjmed.2006.02.002
  40. Lusardi P, Preti P, Savino S, Piazza E, Zoppi A, Fogari R. Effect of bedtime melatonin ingestion on blood pressure of normotensive subjects. Blood Press Monit. 1997;2(2):99-103.
  41. Rechcinski T, Trzos E, Wierzbowska-Drabik K, Krzeminska-Pakula M, Kurpesa M. Melatonin for nondippers with coronary artery disease: Assessment of blood pressure profile and heart rate variability. Hypertens Res. 2010;33(1):56-61. https://doi.org/10.1038/hr.2009.174
  42. Cagnacci A, Cannoletta M, Renzi A, Baldassari F, Arangino S, Volpe A. Prolonged melatonin administration decreases nocturnal blood pressure in women. Am J Hypertens. 2005;18(12 Pt 1):1614-1618. https://doi.org/10.1016/j.amjhyper.2005.05.008
  43. Tan DX, Manchester LC, Reiter RJ. Ischemia/reperfusion-induced arrhythmias in the isolated rat heart: prevention by melatonin. J Pineal Res. 1998;25(3):184-91. https://doi.org/10.1111/j.1600-079X.1998.tb00558.x
  44. Grossman E, Laudon M, Zisapel N. Effect of melatonin on nocturnal blood pressure: meta-analysis of randomized controlled trials.Vasc. Health Risk Manag. 2011;7:577-584. https://doi.org/10.2147/vhrm.s24603
  45. De la Sierra A, Redon J, Banegas JR, et al. Prevalence and factors associated with circadian blood pressure patterns in hypertensive patients. Hypertension. 2009;53(3):466-472. https://doi.org/10.1161/hypertensionaha.108.124008
  46. Hermida RC, Ayala DE, Mojon A, Fernandez JR. Influence of circadian time of hypertension treatment on cardiovascular risk: Results of the MAPEC study. Chronobiol Int. 2010;27(8):1629-1651. https://doi.org/10.3109/07420528.2010.510230
  47. Buscemi N, Vandermeer B, Hooton N, et al. The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis. J Gen Intern Med. 2005;20(12):1151-1158. https://doi.org/10.1136/bmj.38731.532766.f6
  48. Staessen JA, Thijs L, Fagard R, et al. Predicting cardiovascular risk using conventional vs ambulatory blood pressure in older patients with systolic hypertension. Systolic Hypertension in Europe Trial Investigators. JAMA. 1999;282(6):539-546. https://doi.org/10.1001/jama.282.6.539
  49. Mozdzan M, Chalubinski M et al. The effect of melatonin on circadian blood pressure in patients with type 2 diabetes and essential hypertension. Arch Med Sci. 2014;10(4):669-675. https://doi.org/10.5114/aoms.2014.44858
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.