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L'vov D.K.
FGBU "NII virusologii im. D.I. Ivanovskogo" Minzdrava Rossii, Moskva
Kolobukhina L.V.
FGBU "NII virusologii im. D.I. Ivanovskogo" Minzdrava Rossii, Moskva
Burtseva E.I.
FGBU "NII virusologii im. D.I. Ivanovskogo" Minzdrava Rossii, Moskva
Kruzhkova I.S.
FGBU "NII virusologii im. D.I. Ivanovskogo" Minzdrava Rossii, Moskva
Malyshev N.A.
GBUZ "Infektsionnaia klinicheskaia bol'nitsa #1 Departamenta zdravookhraneniia, Moskva
Fedyakina I.T.
D.I. Ivanovsky Institute of Virology, Honorary Acad. N.F. Gamaleya Federal Research Centre for Epidemiology and Microbiology, Ministry of Health of Russia, Moscow, Russia
Kirillova E.S.
D.I. Ivanovsky Institute of Virology, Honorary Acad. N.F. Gamaleya Federal Research Centre for Epidemiology and Microbiology, Ministry of Health of Russia, Moscow, Russia
Trushakova S.V.
FGBU "NII virusologii im. D.I. Ivanovskogo" Minzdrava Rossii, Moskva
Feodoritova E.L.
D.I. Ivanovsky Institute of Virology, Honorary Acad. N.F. Gamaleya Federal Research Centre for Epidemiology and Microbiology, Ministry of Health of Russia, Moscow, Russia
Merkulova L.N.
FGBU "NII virusologii im. D.I. Ivanovskogo" Minzdrava Rossii, Moskva
Krasnoslobodtsev K.G.
D.I. Ivanovsky Institute of Virology, Honorary Acad. N.F. Gamaleya Federal Research Centre for Epidemiology and Microbiology, Ministry of Health of Russia, Moscow, Russia
Mukasheva Е.A.
D.I. Ivanovsky Institute of Virology, Honorary Acad. N.F. Gamaleya Federal Research Centre for Epidemiology and Microbiology, Ministry of Health of Russia, Moscow, Russia
Garina E.O.
D.I. Ivanovsky Institute of Virology, Honorary Acad. N.F. Gamaleya Federal Research Centre for Epidemiology and Microbiology, Ministry of Health of Russia, Moscow, Russia
Vartanian R.V.
FGBU "NII virusologii im. D.I. Ivanovskogo" Minzdrava Rossii, Moskva
Kisteneva L.B.
FGBU "NII virusologii im. D.I. Ivanovskogo" Minzdrava Rossii, Moskva
Prilipov A.G.
FGBU "NII virusologii im. D.I. Ivanovskogo" Minzdrava Rossii, Moskva
Bazarova M.V.
GBUZ "Infektsionnaia klinicheskaia bol'nitsa #1 Departamenta zdravookhraneniia, Moskva
Devjatkin A.V.
Tsentral'naja klinicheskaja bol'nitsa s poliklinikoj Upravlenija delami Prezidenta RF, Moskva, Rossija, 121356
Sutochnikova O.A.
FGBU "NII pul'monologii" FMBA Rossii, Moskva
The 2015-2016 epidemic season in Russia and the world: Circulation of influenza viruses, trends in incidence, clinical aspects, and treatment algorithm
Journal: Therapeutic Archive. 2016;88(11): 112‑120
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To cite this article:
L'vov DK, Kolobukhina LV, Burtseva EI, et al. . The 2015-2016 epidemic season in Russia and the world: Circulation of influenza viruses, trends in incidence, clinical aspects, and treatment algorithm. Therapeutic Archive.
2016;88(11):112‑120. (In Russ.)
https://doi.org/10.17116/terarkh20168811112-120
In the 2015—2016 epidemic season, there were dominant influenza A(H1N1)pdm09 strains (over 90%) among the circulating influenza viruses in most countries of the Northern Hemisphere and in Russia. A study of the antigenic properties of influenza A(H1N1)pdm09 strains revealed no differences in those of vaccine virus. Sequencing showed that there were amino acid substitutions in hemagglutinin (receptor binding and Sa sites) and in the genes encoding internal proteins (PA, NP, M1, and NS1). The rise in the incidence in the Russian Federation, which was etiologically associated with influenza viruses, was registered in January-February 2016 with its maximum being observed at 4—5 weeks of 2016. Within the framework of the epidemiological surveillance of circulating influenza viruses in the Russian Federation, which was conducted by the WHO European Office, the D.I. Ivanovsky Institute of Virology, Honorary Academician N.F. Gamaleya Federal Research Centre for Epidemiology and Microbiology, Ministry of Health of Russia, and the Research Institute of Influenza, Ministry of Health of Russia, monitored at the Infectious Diseases Hospital One (IDH-1), Moscow Healthcare Department. Among 1491 examinees, influenza was verified in 104 (21.3%) adults, 208 (42.5%) pregnant women, and 177 (36.2%) children. Influenza A(H1N1)pdm09 was more often diagnosed in the age group of 15—40 years (63.7%); the proportion of influenza patients aged over 50 years increased (22.1%). Most adult patients had moderate influenza; pneumonia complicated the disease in 27.4%. Influenza in the pregnant women was complicated by pneumonia in 4.8% of cases. Influenza was more frequently diagnosed in infants and preschool children aged 0 to 3 years (42.9%), 4 to 6 years (41.2%), and older (15.9%), namely: 7—9 years (10%) and 10—12 years (5.9%). Influenza in the children was complicated by acute tonsillitis (19.4%) and varying degrees of laryngeal stenosis (12.4%). Bronchial obstructive syndrome developed in 2.5%, the rate of pneumonia was 6.2%. Antiviral therapy (AVT) in the early stages of the disease reduces the risk of its severity, the frequency of secondary complications, and the duration and degree of clinical symptoms of influenza. AVT with oseltamivir, zanamivir, imidazolyl ethanamide pentandioic acid (ingavirin), and interferon-a2b (viferon) has been performed in the patients hospitalized at Moscow IDH-1 in the 2015—2016 epidemic season.
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Authors:
L'vov D.K.
FGBU "NII virusologii im. D.I. Ivanovskogo" Minzdrava Rossii, Moskva
Kolobukhina L.V.
FGBU "NII virusologii im. D.I. Ivanovskogo" Minzdrava Rossii, Moskva
Burtseva E.I.
FGBU "NII virusologii im. D.I. Ivanovskogo" Minzdrava Rossii, Moskva
Kruzhkova I.S.
FGBU "NII virusologii im. D.I. Ivanovskogo" Minzdrava Rossii, Moskva
Malyshev N.A.
GBUZ "Infektsionnaia klinicheskaia bol'nitsa #1 Departamenta zdravookhraneniia, Moskva
Fedyakina I.T.
D.I. Ivanovsky Institute of Virology, Honorary Acad. N.F. Gamaleya Federal Research Centre for Epidemiology and Microbiology, Ministry of Health of Russia, Moscow, Russia
Kirillova E.S.
D.I. Ivanovsky Institute of Virology, Honorary Acad. N.F. Gamaleya Federal Research Centre for Epidemiology and Microbiology, Ministry of Health of Russia, Moscow, Russia
Trushakova S.V.
FGBU "NII virusologii im. D.I. Ivanovskogo" Minzdrava Rossii, Moskva
Feodoritova E.L.
D.I. Ivanovsky Institute of Virology, Honorary Acad. N.F. Gamaleya Federal Research Centre for Epidemiology and Microbiology, Ministry of Health of Russia, Moscow, Russia
Merkulova L.N.
FGBU "NII virusologii im. D.I. Ivanovskogo" Minzdrava Rossii, Moskva
Krasnoslobodtsev K.G.
D.I. Ivanovsky Institute of Virology, Honorary Acad. N.F. Gamaleya Federal Research Centre for Epidemiology and Microbiology, Ministry of Health of Russia, Moscow, Russia
Mukasheva Е.A.
D.I. Ivanovsky Institute of Virology, Honorary Acad. N.F. Gamaleya Federal Research Centre for Epidemiology and Microbiology, Ministry of Health of Russia, Moscow, Russia
Garina E.O.
D.I. Ivanovsky Institute of Virology, Honorary Acad. N.F. Gamaleya Federal Research Centre for Epidemiology and Microbiology, Ministry of Health of Russia, Moscow, Russia
Vartanian R.V.
FGBU "NII virusologii im. D.I. Ivanovskogo" Minzdrava Rossii, Moskva
Kisteneva L.B.
FGBU "NII virusologii im. D.I. Ivanovskogo" Minzdrava Rossii, Moskva
Prilipov A.G.
FGBU "NII virusologii im. D.I. Ivanovskogo" Minzdrava Rossii, Moskva
Bazarova M.V.
GBUZ "Infektsionnaia klinicheskaia bol'nitsa #1 Departamenta zdravookhraneniia, Moskva
Devjatkin A.V.
Tsentral'naja klinicheskaja bol'nitsa s poliklinikoj Upravlenija delami Prezidenta RF, Moskva, Rossija, 121356
Sutochnikova O.A.
FGBU "NII pul'monologii" FMBA Rossii, Moskva
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