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Shestakova M.V.

Institut diabeta Éndokrinologicheskogo nauchnogo tsentra, Moskva

Sukhareva O.Iu.

Institut diabeta Éndokrinologicheskogo nauchnogo tsentra, Moskva

Chernova T.O.

FGBU "ndokrinologicheskiĭ nauchnyĭ tsentr" Minzdrava RF

Shmushkovich I.A.

FGBU "Éndokrinologicheskiĭ nauchnyĭ tsentr" MZ RF, Moskva

Aleksandrov A.A.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr Minzdravsotsrazvitiia RF, Moskva

Il'in A.V.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Dedov I.I.

Endocrinology Research Centre

A combination of dipeptidyl peptidase-4 inhibitor and metformin in the treatment of patients with type 2 diabetes mellitus: effective control of glycemia, weight, and quantitative body composition

Authors:

Shestakova M.V., Sukhareva O.Iu., Chernova T.O., Shmushkovich I.A., Aleksandrov A.A., Il'in A.V., Dedov I.I.

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Journal: Therapeutic Archive. 2013;85(8): 49‑55

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A COMBINATION OF DIPEPTIDYL PEPTIDASE-4 INHIBITOR AND METFORMIN IN THE TREATMENT OF PATIENTS WITH TYPE 2 DIABETES MELLITUS: EFFECTIVE CONTROL OF GLYCEMIA, WEIGHT, AND QUANTITATIVE BODY COMPOSITION
A COMBINATION OF DIPEPTIDYL PEPTIDASE-4 INHIBITOR AND METFORMIN IN THE TREATMENT OF PATIENTS WITH TYPE 2 DIABETES MELLITUS: EFFECTIVE CONTROL OF GLYCEMIA, WEIGHT, AND QUANTITATIVE BODY COMPOSITION

To cite this article:

Shestakova MV, Sukhareva OIu, Chernova TO, Shmushkovich IA, Aleksandrov AA, Il'in AV, Dedov II. A combination of dipeptidyl peptidase-4 inhibitor and metformin in the treatment of patients with type 2 diabetes mellitus: effective control of glycemia, weight, and quantitative body composition. Therapeutic Archive. 2013;85(8):49‑55. (In Russ.)

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Aim. To study the impact of intensified therapy with the dipeptidyl peptidase-4 (DPP-4) inhibitor vilagliptin or sulfonylurea (SU) on the control of glycemia, weight, and quantitative body composition in patients with type 2 diabetes mellitus (DM-2) who have failed to achieve compensation during metformin monotherapy. Subjects and methods. Forty patients (mean age 55.0 (range 53.0-60.7) years; disease duration 2.0 (range 1.1-5.0) years) with poor glycemic control (7%

Keywords:

type 2 diabetes mellitus
quantitative body composition
adiponectin
vildagliptin

Authors:

Shestakova M.V.

Institut diabeta Éndokrinologicheskogo nauchnogo tsentra, Moskva

Sukhareva O.Iu.

Institut diabeta Éndokrinologicheskogo nauchnogo tsentra, Moskva

Chernova T.O.

FGBU "ndokrinologicheskiĭ nauchnyĭ tsentr" Minzdrava RF

Shmushkovich I.A.

FGBU "Éndokrinologicheskiĭ nauchnyĭ tsentr" MZ RF, Moskva

Aleksandrov A.A.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr Minzdravsotsrazvitiia RF, Moskva

Il'in A.V.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Dedov I.I.

Endocrinology Research Centre

List of references:

  1. Turner R.C., Cull C.A., Frighi V., Holman R.R. Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). JAMA 1999; 281: 2005-2012.
  2. Dedov I.I., Shestakova M.V., Sukhareva O.Yu. Innovatsii v lechenii sakharnogo diabeta 2-go tipa: primenenie inkretinov. Ter arkh 2010; 10: 5-10.
  3. International Diabetes Federation. Treatment Algorithm for People with Type 2 Diabetes. Dostupno na http://www.idf.org/treatment-algorithm-people-type-2-diabetes.
  4. Dedov I.I., Shestakova M.V., Ametov A.S. i dr. Konsensus soveta ekspertov Rossiiskoi assotsiatsii endokrinologov po initsiatsii i intensifikatsii sakharosnizhayushchei terapii SD-2-go tipa. Sakharnyi diabet 2011; 4: 6-17.
  5. Inzucchi S.E., Bergenstal R.M., Buse J.B. et al. Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia 2012; 55: 1577-1596.
  6. Hubert H.B., Feinleib M., McNamara P.T., Castell W.P. Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants of the Framingham Heart Study. Circulation 1983; 67: 968-977.
  7. Dedov I.I., Mel'nichenko G.A., Romantsova T.I. Patogeneticheskie aspekty ozhireniya. Ozhirenie i metabolizm 2004; 1: 3-9.
  8. Koenig W., Khuseyinova N., Baumert J. et al. Serum concentrations of adiponectin and risk of type 2 diabetes mellitus and coronary heart disease in apparently healthy middleaged men: results from the 18-year follow-up of a large cohort from southern Germany. J Am Coll Cardiol 2006; 48: 1369-1377.
  9. Mazess R.B., Barden H.S. Measurement of bone by dual-photon absorptiometry (DPA) and dual-energy X-ray absorptiometry (DEXA). Ann Chir Gynaecol 1988; 77 (5-6): 197-203.
  10. Holst J. The physiology and pharmacology of incretins in type 2 diabetes. Diabetes Obes Metab 2008; 10 (Suppl 3): 14-21.
  11. Balas B., Baig M.R. The Dipeptidyl Peptidase IV Inhibitor Vildagliptin Suppresses Endogenous Glucose Production and Enhances Islet Function after Single-Dose Administration in Type 2 Diabetic Patients. J Clin Endocrinol Metabol 2007; 92 (4): 1249 -1255.
  12. Ussher J.R., Drucker D.J. Cardiovascular biology of the incretin System. Endocrine Rev 2012; 33 (2): 187-215.
  13. Butrova S.A., Dzgoeva F.Kh. Vistseral'noe ozhirenie - klyuchevoe zveno metabolicheskogo sindroma. Ozhirenie i metabolizm 2004; 1: 10-13.
  14. Despres J.P. Inflammation and cardiovascular disease: is abdominal obesity the missing link? Int J Obes 2003; 27 (Suppl): 22-24.

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