Forensic chemical and chemicotoxicological examination of ricin poisoning by the HPLC-MS/MS method

Kalekin R.A.; Barseghyan S.S.; Volkova A.A.; Orlova A.M.; Akimova V.D.

doi:https://doi.org/10.17116/sudmed20236603134

Kalekin R.A.

Russian Center of Forensic Medical Examination;
Peoples’ Friendship University of Russia

ORCID: 0000-0002-4989-3511

Barseghyan S.S.

Russian Center of Forensic Medical Examination;
Peoples’ Friendship University of Russia

ORCID: 0000-0002-9882-2330

Volkova A.A.

Russian Center of Forensic Medical Examination

ORCID: 0000-0002-5419-1418

Orlova A.M.

Russian Center of Forensic Medical Examination

ORCID: 0000-0003-0689-7704

Akimova V.D.

Russian Center of Forensic Medical Examination

ORCID: 0000-0001-6234-4253

Forensic chemical and chemicotoxicological examination of ricin poisoning by the HPLC-MS/MS method

Authors:

Kalekin R.A., Barseghyan S.S., Volkova A.A., Orlova A.M., Akimova V.D.

More about the authors

Journal: Forensic Medical Expertise. 2023;66(3): 34‑39

DOI: 10.17116/sudmed20236603134

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To cite this article:

Kalekin RA, Barseghyan SS, Volkova AA, Orlova AM, Akimova VD. Forensic chemical and chemicotoxicological examination of ricin poisoning by the HPLC-MS/MS method. Forensic Medical Expertise. 2023;66(3):34‑39. (In Russ.)
https://doi.org/10.17116/sudmed20236603134

Подписка 2026 Судебно-медицинская экспертиза (Forensic Medical Expertise)

Использование инфографики авторами научных работ

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THE AIM OF THE STUDY

Is to suggest the method of ricin determination in biological liquids during forensic medical and chemicotoxicological examination. This research describes the optimal conditions of sample processing of biological liquids, allowing to extract the components (ricinine and ricinoleic acid) of castor seeds. The recommended analysis conditions allow to perform research for 15 minutes by high resolution mass spectrometry method combined with high-value liquid chromatography on a chromato-mass spectrometer to detect ricinine and ricinoleic acid. The chromatographic (retention time) and mass-spectrometric parameters (mass spectra) were established for the exact high-quality determination of ricinine and ricinoleic acid.

Keywords:

ricin

ricinine

ricinoleic acid

castor-oil plant

blood

urine

forensic chemical examination

chemicotoxicological examination

Authors:

Kalekin R.A.

Russian Center of Forensic Medical Examination;
Peoples’ Friendship University of Russia

ORCID: 0000-0002-4989-3511

Barseghyan S.S.

Russian Center of Forensic Medical Examination;
Peoples’ Friendship University of Russia

ORCID: 0000-0002-9882-2330

Volkova A.A.

Russian Center of Forensic Medical Examination

ORCID: 0000-0002-5419-1418

Orlova A.M.

Russian Center of Forensic Medical Examination

ORCID: 0000-0003-0689-7704

Akimova V.D.

Russian Center of Forensic Medical Examination

ORCID: 0000-0001-6234-4253

Received:

26.10.2022

Accepted:

07.12.2022

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References:

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