Main directions of scientific and scientific-practical activity of the professor Mikhail Ivanovich Avdeev are described in the article. These include: a set of scientific tasks to justify the staff and organizational structure, organization and justification of the expert work content in the specialized military forensic service, including the training programs development for specialization and thematic improvement of forensic experts; determining the limits of competence for forensic experts in determining the violent death type; systematization of causes and death conditions; establishing structure of sudden death causes in young persons; assessment of the pathogenetic role of trauma and pathology in the development of basal subarachnoid hemorrhages; formulation of the conceptual base content for forensic medicine; justification of a scientifically based sequence of forensic medicine reproduction; creation of a scientific school of military forensic experts; preparation and publication of about 50 textbooks, manuals and, monographs on forensic medicine, including the fundamental work «Forensic Medicine Course», «Forensic Examination of Living People», «Forensic Corpse Examination».