The morphological changes in the myocardium associated with the craniocerebral injury

Boyarinov G.A.; Derugina A.V.; Zaitsev R.R.; Yakovleva E.I.; Nikolsky V.O.; Boyarinova L.V.; Galkina M.V.

doi:https://doi.org/10.17116/sudmed20176014-7

Boyarinov G.A.

Nizhny Novgorod State Medical University, Russian Ministry of Health, Nizhny Novgorod, Russia, 603950

Derugina A.V.

National Research University «Lobachevsky Nizhny Novgorod State University», Nizhny Novgorod

Zaitsev R.R.

Nizhny Novgorod State Medical University, Russian Ministry of Health, Nizhny Novgorod, Russia, 603950

Yakovleva E.I.

Nizhny Novgorod State Medical University, Russian Ministry of Health, Nizhny Novgorod, Russia, 603950

Nikolsky V.O.

Nizhny Novgorod Regional Clinical Tuberculosis Dispensary, Nizhny Novgorod, Russia

Boyarinova L.V.

Nizhny Novgorod State Medical University, Russian Ministry of Health, Nizhny Novgorod, Russia, 603950

Galkina M.V.

Nizhny Novgorod State Medical University, Russian Ministry of Health, Nizhny Novgorod, Russia, 603950

The morphological changes in the myocardium associated with the craniocerebral injury

Authors:

Boyarinov G.A., Derugina A.V., Zaitsev R.R., Yakovleva E.I., Nikolsky V.O., Boyarinova L.V., Galkina M.V.

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Journal: Forensic Medical Expertise. 2017;60(1): 4‑7

DOI: 10.17116/sudmed20176014-7

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To cite this article:

Boyarinov GA, Derugina AV, Zaitsev RR, Yakovleva EI, Nikolsky VO, Boyarinova LV, Galkina MV. The morphological changes in the myocardium associated with the craniocerebral injury. Forensic Medical Expertise. 2017;60(1):4‑7. (In Russ.)
https://doi.org/10.17116/sudmed20176014-7

Подписка 2026 Судебно-медицинская экспертиза (Forensic Medical Expertise)

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Abstract:

The objective of the present study was to evaluate the structural changes in the capillaries, arterioles, venules, and cardiomyocytes in the myocardium of the rats following the craniocerebral injury (CCI). Eighteen non-pedigree white female rats with the craniocerebral injury were used as the CCI model. All the animals were given an intraperitoneal injection of sodium thiopental (100 mg/kg b.w.) within 3, 7, and 12 days after the injury. The heart was removed after thoracotomy and the myocardial tissue was examined with the light and electron microscopes. It was shown that the rats with the craniocerebral injury developed well apparent changes in the myocardial tissue during the early post-traumatic period that affected not only the blood vessels themselves (capillaries, arterioles, venules) but also the intra- and extravascular structures. Changes in the microcirculatory system included damages to the mitochondria, myofibrils, cell nuclei, sarcoplasmic reticulum, and cardiomyocytes. It is concluded that the morphological changes in the myocardium of the animals associated with the craniocerebral injury can induce the development of functional disorders in the cardiovascular system during the early post-traumatic period.

Keywords:

craniocerebral injury

damages to capillaries

arterioles

venules

and cardiomyocytes of the myocardium

Authors:

Boyarinov G.A.

Nizhny Novgorod State Medical University, Russian Ministry of Health, Nizhny Novgorod, Russia, 603950

Derugina A.V.

National Research University «Lobachevsky Nizhny Novgorod State University», Nizhny Novgorod

Zaitsev R.R.

Nizhny Novgorod State Medical University, Russian Ministry of Health, Nizhny Novgorod, Russia, 603950

Yakovleva E.I.

Nizhny Novgorod State Medical University, Russian Ministry of Health, Nizhny Novgorod, Russia, 603950

Nikolsky V.O.

Nizhny Novgorod Regional Clinical Tuberculosis Dispensary, Nizhny Novgorod, Russia

Boyarinova L.V.

Nizhny Novgorod State Medical University, Russian Ministry of Health, Nizhny Novgorod, Russia, 603950

Galkina M.V.

Nizhny Novgorod State Medical University, Russian Ministry of Health, Nizhny Novgorod, Russia, 603950

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