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Kochurova E.V.

Sechenov First Moscow State Medical University, Moscow, Russia

Nikolenko V.N.

Chair of Normal Anatomy, Sechenov First Moscow State Medical University of Ministry of Health of Russia, Moscow, Russia

Mukhanov A.A.

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia, Moscow, Russia

Demenchuk P.A.

Burdenko Main Military Clinical Hospital of the Ministry of Defence of Russia, Moscow, Russia

Dental status as a predictive factor in the development of squamous cell carcinoma of the oral mucosa

Authors:

Kochurova E.V., Nikolenko V.N., Mukhanov A.A., Demenchuk P.A.

More about the authors

Journal: Stomatology. 2019;98(4): 34‑37

DOI: 10.17116/stomat20199804134

Read: 1407 times

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Table of contents

DENTAL STATUS AS A PREDICTIVE FACTOR IN THE DEVELOPMENT OF SQUAMOUS CELL CARCINOMA OF THE ORAL MUCOSA
DENTAL STATUS AS A PREDICTIVE FACTOR IN THE DEVELOPMENT OF SQUAMOUS CELL CARCINOMA OF THE ORAL MUCOSA

To cite this article:

Kochurova EV, Nikolenko VN, Mukhanov AA, Demenchuk PA. Dental status as a predictive factor in the development of squamous cell carcinoma of the oral mucosa. Stomatology. 2019;98(4):34‑37. (In Russ.)
https://doi.org/10.17116/stomat20199804134

Подписка 2026 Стоматология (Stomatology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The aim of this work was to study the influence of components of dental status on the local immunity of the oral cavity; we compared the results of the study of patients with squamous cell carcinoma (SCC) of the oral mucosa and patients without neoplasm. The study involved 136 patients with squamous cell carcinoma of the oral mucosa and 57 patients without neoplasms. In the role of the constituent characteristics of dental status were examined: the use of removable and fixed dentures, dental caries, dental plaque, sharp edges of fullings. Matrix metalloproteinases (MMPs) 2, 8 and 9, as well as their tissue inhibitors 1 and 2 were assessed in oral fluid. The results suggest the influence of all factors on local immune status of the oral cavity as proved by the significant changes in MMPs level. The use of removable dentures resulted in the pronounced decrease of MMPs and should be considered in oral SSC screening and non-invasive diagnostics.

Keywords:

dental status
saliva
biomarkers
oral cavity
cancer

Authors:

Kochurova E.V.

Sechenov First Moscow State Medical University, Moscow, Russia

Nikolenko V.N.

Chair of Normal Anatomy, Sechenov First Moscow State Medical University of Ministry of Health of Russia, Moscow, Russia

Mukhanov A.A.

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia, Moscow, Russia

Demenchuk P.A.

Burdenko Main Military Clinical Hospital of the Ministry of Defence of Russia, Moscow, Russia

Close metadata

References:

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  10. Kochurova EV, Nikolenko VN. Estimation of expression of oral fluid biomarkers in the diagnosis of pretumor diseases of oral mucosa. Bulletin of Experimental Biology and Medicine. 2017;163(1):87-91. https://doi.org/10.1007/s10517-017-3744-8
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