The role of the «male» factor in the causes of ectopic pregnancy is not well defined; the use of immunochemical indicators of the reproductive health of married couples will allow us to expand the range of risk factors for ectopic pregnancy and improve the quality of pre-programmed preparation for married couples. The aim — of this study is to conduct a comprehensive assessment of the reproductive health of couples with ectopic pregnancies, using human reproductive proteins. Material and methods. A total of 103 women and 75 men from couples with a history of ectopic pregnancy were examined, as well as 100 women and 52 men from couples with normal reproductive function. The placental alpha macroglobulin-1 (PAMG-1) and glycodelin level in the peripheral blood and peritoneal fluid were determined by immunoenzymatic analysis. The level of glycodelin and the soluble leukocyte type 2 (RAL-2) antigen in the menstrual blood was determined by immunodiffusion analysis in a full complement of clinical and laboratory examinations. In men, the level of glycodelin and RAL-2 in their semen was also studied. Results. PAMG-1 and glycodelin levels in peripheral venous blood, as well as PAMG-1 levels in peritoneal fluid were not related to the condition of the fallopian tubes in women. In healthy women the concentration of glycodelin in the peritoneal fluid was higher than in the peripheral blood, but was significantly reduced in those women with a history of ectopic pregnancies, especially in cases of obstruction of the remaining fallopian tube. In couples with ectopic pregnancy, a significant increase in RAL-2 and a decrease in glycodelin in the menstrual blood and semen was observed over the course of the pregnancy. Conclusion. Studies of glycodelin and RAL-2 aid in the improved diagnosis of reproductive health disorders in both women and men; help add to the list of known risk factors for ectopic pregnancy; and improve the quality of pregnancy planning for couples.