The importance of proteolytic and oxidative degradation of proteins in the developmentof uterine fibroids

Pogorelova T.N.

Rostovskiĭ NII akusherstva i pediatrii

Gun'ko V.O.

Rostovskiĭ NII akusherstva i pediatrii

Ermolova N.V.

Rostov Research Institute of Obstetrics and Pediatrics, Ministry of Health of Russia, Rostov-on-Don, Russia

Kartashova A.V.

Research Institute of Obstetrics and Pediatrics, Rostov State Medical University, Ministry of Health of Russia, Rostov-on-Don, Russia

Durnitsyna O.A.

Rostov Research Institute of Obstetrics and Pediatrics, Ministry of Health of Russia, Rostov-on-Don, Russia

Alliluev I.A.

Research Institute of Obstetrics and Pediatrics, Rostov State Medical University, Ministry of Health of Russia, Rostov-on-Don, Russia;
Academy of Biology and Biotechnology, Southern Federal University, Rostov-on-Don, Russia

The importance of proteolytic and oxidative degradation of proteins in the developmentof uterine fibroids

Authors:

Pogorelova T.N., Gun'ko V.O., Ermolova N.V., Kartashova A.V., Durnitsyna O.A., Alliluev I.A.

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Journal: Russian Bulletin of Obstetrician-Gynecologist. 2019;19(2): 42‑46

DOI: 10.17116/rosakush20191902142

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To cite this article:

Pogorelova TN, Gun'ko VO, Ermolova NV, Kartashova AV, Durnitsyna OA, Alliluev IA. The importance of proteolytic and oxidative degradation of proteins in the developmentof uterine fibroids. Russian Bulletin of Obstetrician-Gynecologist. 2019;19(2):42‑46. (In Russ.)
https://doi.org/10.17116/rosakush20191902142

Подписка 2025-2 (Russian Bulletin of Obstetrician-Gynecologist)

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Objective — to study the activity of proteolytic destruction and oxidative modification of proteins to clarify the role of molecular mechanisms in the pathogenesis of uterine fibroids. Subject and methods. The investigation enrolled 40 women, 20 of whom were diagnosed with uterine fibroids (a study group). A control group consisted of 20 women without fibroids. Spectrophotometric methods were used to examine the samples of the intact myometrial, myomatous nodule, and serum and to determine the activity of acidic and neutral proteinases and the levels of carbonyl derivatives that were formed during protein oxidative degradation. Results. In uterine fibroids, there was a significantly elevated level of proteinases of both species in all studied biological objects, which was more pronounced for the enzymes that were active in acidic media. The intensity of proteolysis in myomatous tissue exceeded that in the serum of patients with uterine fibroids. There were protein destructive changes due to proteinases during their oxidative modification, the degree of which significantly increased in uterine fibroids. Conclusion. The found changes in the structure and properties of proteins in women with uterine fibroids make it possible to specify the significance of changes in molecular mechanisms in the formation and further development of uterine fibroids.

Keywords:

uterine fibroids

myometrium

serum

proteinase activity

protein oxidative modification

carbonyl derivatives

Authors:

Pogorelova T.N.

Rostovskiĭ NII akusherstva i pediatrii

Gun'ko V.O.

Rostovskiĭ NII akusherstva i pediatrii

Ermolova N.V.

Rostov Research Institute of Obstetrics and Pediatrics, Ministry of Health of Russia, Rostov-on-Don, Russia

Kartashova A.V.

Research Institute of Obstetrics and Pediatrics, Rostov State Medical University, Ministry of Health of Russia, Rostov-on-Don, Russia

Durnitsyna O.A.

Rostov Research Institute of Obstetrics and Pediatrics, Ministry of Health of Russia, Rostov-on-Don, Russia

Alliluev I.A.

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