Objective - to investigate the specific features of blood supply to myomatous nodules of varying sizes, sites, and growth rates by using ultrasonography and Doppler study and to establish the prognostic value of changes in the type of blood supply and in the process of neoangiogenesis in women with uterine myoma at the stage of pregnancy planning. Subject and methods. Examinations were made in 163 patients aged 22 to 42 years (mean age 32±0,3 years) with uterine myoma; among them there were 32 (19.6%) patients with stable uterine myoma (Group 1), 97 (59.5%) with clinical presentation of a rapid nodular growth (Group 2), and 34 (20.9%) with destructive changes in uterine myoma (Group 3). Complex color Doppler ultrasound was performed in all the examinees at the stage of preoperative preparation, 5-7 days and 2-6 months postsurgery. The specific features of angiogenic processes were studied, by determining vascular endothelial growth factor (the angiogenesis stimulator VEGF-A, pg/ml) in the sera of patients examined using standard enzyme immunoassay kits. Results. Doppler ultrasound allows one to draw up a prognosis of uterine myoma growth during pregnancy, by studying the specific features of blood supply (peak blood flow velocity, systolic-diastolic ratio, and resistance index) in the nodules of varying sizes, sites, and growth rate: the prognostic criteria for a rapid myomatous nodular growth are increased peak blood flow velocity, decreased resistance index, and systolic-diastolic ratio in the vessels around the periphery of a nodule. The plasma level of VEGF-A (more than 300 pg/ml) in reproductive-aged patients with uterine myoma is a prognostic criterion for rapidly growing uterine myoma; the level of this factor below 100 pg/ml suggests that changes happen in the nodules. Conclusion. The management tactics for reproductive-aged patients with uterine myoma who plan pregnancy should encompass topical diagnosis of myoma, by drawing up a prognosis of its growth during pregnancy; preoperative preparation with sanitation of foci of infection and treatment of anemia; timely myomectomy for more than 4-5 cm nodules, by complying with the surgical technology that provides conditions for making an adequate uterine scar. The authors declare no conflicts of interest.