Chronic generalized periodontitis (CHP) negatively affects teeth and periodontium, leading to tooth loss. The use of orthopedic structures against the background of CHP exacerbates the situation, increasing the frequency of exposure of tooth roots and wedge-shaped defects, as well as worsening the condition of the gum and periodontal tissues. Despite this, orthopedic treatment may have some stabilizing effect on the dentition in periodontitis, slowing the progression of defects. CHP also affects the biochemical composition of saliva, in particular, reduces the level of cystatin C and increases the level of D-dimer, while orthopedic treatment partially corrects the level of cystatin C. Therefore, a comprehensive approach to the treatment of patients with periodontitis is required, including periodontological treatment, careful planning of orthopedic treatment and prevention.