Aim — to evaluate peripheral blood cell ratio and biochemical parameters in facial phlegmon patients. Material and methods. A retrospective analysis of 132 facial phlegmon patients’ medical records was conducted. Patients were divided into groups according to their leukocyte index. Control group was comprised of 26 almost healthy people. Leukocyte formula and absolute number of leukocytes were counted. We used a complex of leukocyte indices to characterize endogenic intoxication. Concentration of blood protein, glucose, ALT, AST, fibrinogen, C-reactive protein were measured. Statistical analysis was conducted using independent Student’s t-test and Pearson’s correlation coefficient (r). Differences were considered statistically reliable with p<0.05 Results. In patients with facial phlegmon we observed leukocyte left shift, which is more pronounced in patients with endogenic intoxication. More than that, in state of endogenic intoxication relative leukocyte number is decreased, C-reactive protein is elevated; such patients have increased duration of hospital stay. Fibrinogen level in patients of the first group was higher than in the second group. That may be related to the leukocyte activity (r=0.32). However, in the second group this state was leveled as fibrinogen level was falling because of the high toxic load, which can be regarded as the key pathogenesis point. Conclusion. Acute inflammation in facial phlegmon patients is characterized by variation of blood cell ratio. Endogenic intoxication in these patients correlates with variation of blood biochemical parameters.