Possibilities of using bacterial lysates in the treatment and prevention of upper respiratory tract infectious diseases

Kim I.A.; Trukhin D.V.; Sukhostavtseva T.V.

doi:https://doi.org/10.17116/rosrino202432041314

OBJECTIVE

Analysis and summary of published data on the significance of topical bacterial lysates in contemporary treatment and prevention algorithms for acute and chronic upper respiratory tract infections.

MATERIAL AND METHODS

We analyzed publications indexed in Medline, Embase, and PubMed databases. The materials were selected using keywords such as UTR infections, immunotherapy, immunoprophylaxis, topical bacterial lysates, and Imudon.

RESULTS

Topical bacterial lysates, which are preparations consisting of a mixture of antigens from inactivated bacteria — the most common causative agents of infectious diseases — act directly at the site of inflammation without negatively impacting the human microbiome. They have a high safety profile, combine well with other medications, and can be used in patients of various ages. Using the topical immunomodulator Imudon in patients with URT infections helps reduce the frequency of acute episodes and exacerbations of chronic respiratory diseases, significantly decrease their duration, lessen the severity, and prevent the development of complications. In addition to its high efficacy, Imudon preparation has been well tolerated.

CONCLUSION

Topical immunotherapy has a distinct preventive effect, helping to avert potential complications and improving the quality of life for patients. This allows for the inclusion of the topical immunomodulator Imudon in the comprehensive treatment of acute infections and the prevention of recurrent URT infections.

Keywords:

upper respiratory tract infections

immunotherapy

immunoprophylaxis

topical bacterial lysates

Imudon

Authors:

Kim I.A.

National Medical Research Center for Otorhinolaryngology;
N.I. Pirogov Russian National Research Medical University

ORCID: 0000-0003-1078-6388

Trukhin D.V.

National Medical Research Center for Otorhinolaryngology;
N.I. Pirogov Russian National Research Medical University

ORCID: 0000-0002-7527-5944

Sukhostavtseva T.V.

National Medical Research Center for Otorhinolaryngology;
N.I. Pirogov Russian National Research Medical University

ORCID: 0000-0003-4282-1643

Received:

08.10.2024

Accepted:

17.10.2024

Close metadata

References:

O sostoyanii sanitarno-epidemiologicheskogo blagopoluchiya naseleniya v Rossiiskoi Federatsii v 2022 godu: Gosudarstvennyi doklad. M.: Federal’naya sluzhba po nadzoru v sfere zashchity prav potrebitelei i blagopoluchiya cheloveka; 2023. (In Russ.).
Ashworth M, et al. Why has antibiotic prescribing for respiratory illness declined in primary care? A longitudinal study using the General Practice Research Database. Journal of Public Health. 2004;26(3):268-274.
Braido F, Tarantini F, Ghiglione V, Melioli G, Canonica GW. Bacterial lysate in the prevention of acute exacerbation of COPD and in respiratory recurrent infections. International journal of chronic obstructive pulmonary disease. 2007;2(3):335-345.
Kumpitsch C, Koskinen K, Schöpf V, Moissl-Eichinger C. The microbiome of the upper respiratory tract in health and disease. BMC biology. 2019;17(1):87. https://doi.org/10.1186/s12915-019-0703-z
Nosulya EV, Kim IA, Chernykh NM, Karnoukhova OA. Acute tonsillopharyngitis: the effectiveness of topical therapy. Russian Bulletin of Otorhinolaryngology. 2015;80(5):71-76. (In Russ.). https://doi.org/10.17116/otorino201580571-76
Sender V, Hentrich K, Henriques-Normark B. Virus-induced changes of the respiratory tract environment promote secondary infections with Streptococcus pneumoniae. Frontiers in Cellular and Infection Microbiology. 2021;11:643326. https://doi.org/10.3389/fcimb.2021.643326
Andreeva IV, Stecjuk OU. Infektsii dykhatel’nykh putei: novyi vzglyad na starye problemy. Klinicheskaya Mikrobiologiya i Antimikrobnaya Khimioterapiya. 2009;11(2):143-151. (In Russ.).
Pal’chun VT, Kryukov AI, Gurov AV, Ermolaev AG. Palatine tonsils: physiology and pathology. Russian Bulletin of Otorhinolaryngology. 2019;84(6): 11-16. (In Russ.). https://doi.org/10.17116/otorino20198406111
Mustafa Z, Ghaffari M. Diagnostic Methods, Clinical Guidelines, and Antibiotic Treatment for Group A Streptococcal Pharyngitis: A Narrative Review. Frontiers in Cellular and Infection Microbiology. 2020;10:563627. https://doi.org/10.3389/fcimb.2020.563627
Bogomil’skii MR, Chistyakova VR. Detskaya otorinolaringologiya. M.: GEOTAR-Media; 2002. (In Russ.).
Bykova VP. Morfofunktsional’naya organizatsiya nebnykh mindalin kak limfoepitelial’nogo organa. Vestnik otorinolaringologii. 1998;1:41-45. (In Russ.).
Garashchenko TI, Volodarskaya VG. Smes’ lizatov bakterii dlya topicheskogo primeneniya v profilaktike i lechenii khronicheskogo tonzillita u detei. Voprosy sovremennoi pediatrii. 2009;6:109-112. (In Russ.).
Glesby M, Pyeritz R. Association of mitral valve prolapsed and systemic abnormalities of connective tissue. A phenotypic continuum. JAMA. 1989;262:523-528. https://doi.org/10.1001/jama.1989.03430040095032
Kivirikko K. Collagens and their abnormalities in a wide spectrum of diseases. Annals of medicine. 1993;25(2):113-126. https://doi.org/10.3109/07853899309164153
Garashchenko TI, Kozarezova TI. Sostoyanie gemokoagulyatsii i fibrinoliticheskikh svoistv krovi pri khronicheskom tonzillite u bol’nykh gemorragicheskim vaskulitom. Zhurnal ushnykh, nosovykh, gorlovykh boleznei. 1981;4:50-53. (In Russ.).
Kitaigorodskii AP. O polozhitel’nom effekte adenotonzillektomii u detei, bol’nykh khronicheskim tonzillitom, adenoiditom, sakharnym diabetom. Vestnik otorinolaringologii. 1984;3:34-38. (In Russ.).
Respiratory Tract Infections - Antibiotic Prescribing: Prescribing of Antibiotics for Self-Limiting Respiratory Tract Infections in Adults and Children in Primary Care. London: National Institute for Health and Clinical Excellence (NICE); 2008.
Action Programme on Essential Drugs: progress report 1996, interim report of the biennium 1996-1997. World Health Organization; 1997. Accessed October 15, 2024. https://iris.who.int/handle/10665/63356
Leblebicioglu H, Canbaz S, Peksen Y, Gunaydin M. Physician’s antibiotic prescribing habits for upper respiratory tract infectionsin Turkey. Journal of chemotherapy. 2002;14:181-184. https://doi.org/10.1179/joc.2002.14.2.181
Ortenberg EA, Strachunskij LS, Kozlov SN, Kuzin VB, Rachina SA, Sosonnaya NA, Palyutin ShH, Dmitrenok OV, Ilyushchenko LA. Pharmacotherapy of acute tonsillopharyngitis in outpatient setting: results of a multicenter pharmacoepidemiological study. Terapevticheskii arkhiv. 2004;76(5):45-51. (In Russ.).
Harper K, Armelagos G. The changing disease-scape in the third epidemiological transition. International journal of environmental research and public health. 2010;7(2):675-697. https://doi.org/10.3390/ijerph7020675
Lyamin AV, Botkin EA, Zhestkov AV. Medical Problems Associated with Bacterial Biofilms. Klinicheskaya mikrobiologiya i antimikrobnaya khimioterapiya. 2012;14(4):268-275. (In Russ.).
Suh JD, Cohen NA, Palmer JN. Biofilms in chronic rhinosinusitis. Current Opinion in Otolaryngology and Head and Neck Surgery. 2010;18(1):27-31. https://doi.org/10.1097/MOO.0b013e328334f670
Karaulov AV, Kokushkov DV. Effektivnost’ immunoterapii s ispol’zovaniem IRS 19 u bol’nykh khronicheskim bronkhitom. Atmosfera. Pul’monologiya i allergologiya. 2005;3:61-63. (In Russ.).
Kondratenko IV, Bologov AA. Pervichnye immunodefitsity. M.: Medpraktika; 2005. (In Russ.).
Selimzyanova LR. Mesto topicheskikh bakterial’nykh lizatov v pediatricheskoi praktike. Pediatricheskaya farmakologiya. 2009;6(2):26-30. (In Russ.).
Bulgakova VA, Balabolkin II, Ushakova VV. Sovremennoe sostoyanie problemy chasto boleyushchikh detei. Pediatricheskaya farmakologiya. 2007;4(2):48-52. (In Russ.).
Miravitlles M. Prevention of exacerbations of COPD with pharmacotherapy. European Respiratory Review. 2010;19(116):119-126. https://doi.org/10.1183/09059180.00002810
Tatochenko VK, Ozeretskovskii NA. Immunoprofilaktika-2018: spravochnik, 13-e izdanie, rasshirennoe. M.: Borges; 2018. (In Russ.).
Esposito S, Soto-Martinez ME, Feleszko W, Jones MH, Shen KL, Schaad UB. Nonspecific immunomodulators for recurrent respiratory tract infections, wheezing and asthma in children: a systematic review of mechanistic and clinical evidence. Current opinion in allergy and clinical immunology. 2018;18(3):198-209. https://doi.org/10.1097/ACI.0000000000000433
Karpova EP, Zaplatnikov AL, Tulupov DA. Immunoprophylaxis of infections of the upper respiratory tract in the frequently ill children. Russian Bulletin of Otorhinolaryngology. 2015;80(5):80-84. (In Russ.). https://doi.org/10.17116/otorino201580580-84
Carlone S, Minenna M, Morlino P, Mosca L, Pasqua F, Pela R, Schino P, Tubaldi A, Tupputi E, De Benedetto F; Buccalin Trial Group. Clinical efficacy and tolerability of an immune-stimulant* constituted by inactivated bacterial bodies in the prophylaxis of infectious episodes of airways: a double blind, placebo-controlled, randomized, multicentre study. Multidisciplinary Respiratory Medicine. 2014;9(1):58. https://doi.org/10.1186/2049-6958-9-58
Navarro S, Cossalter G, Chiavaroli C, Kanda A, Fleury S, Lazzari A, Cazareth J, Sparwasser T, Dombrowicz D, Glaichenhaus N, Julia V. The oral administration of bacterial extracts prevents asthma via the recruitment of regulatory T cells to the airways. Mucosal Immunology. 2011;4(1):53-65. https://doi.org/10.1038/mi.2010.51
Mikhailov IB. Korrektsiya vtorichnogo priobretennogo immunodefitsita u detei i vzroslykh: Metod. posobie dlya vrachei. St-Petersburg; 2007. (In Russ.).
Hancock RE, Nijnik A, Philpott DJ. Modulating immunity as a therapy for bacterial infections. Nature Reviews Microbiology. 2012;10(4):243-254. https://doi.org/10.1038/nrmicro2745
Cazzola M, Anapurapu S, Page CP. Polyvalent mechanical bacterial lysate for the prevention of recurrent respiratory infections: a meta-analysis. Pulmonary pharmacology & therapeutics. 2012;25(1):62-68. https://doi.org/10.1016/j.pupt.2011.11.002
Karaulov AV, Kalyuzhin OV. Immunotropnye preparaty: printsipy primeneniya i klinicheskaya effektivnost’. M.; 2007. (In Russ.).
Zaplatnikov AL. Immunokorrektory bakterial’nogo proiskhozhdeniya v profilaktike i lechenii respiratornykh infektsii u detei. Rossiiskii pediatricheskii zhurnal. 2002;1:45-48. (In Russ.).
Markova TP, Chuvirov DG. Pathogenetic mechanism of bacterial immune modulators’ action in children with common cold. Voprosy sovremennoi pediatrii. 2003;1:85-88. (In Russ.).
Del-Rio-Navarro BE, Espinosa Rosales F, Flenady V, Sienra-Monge JJ. Immunostimulants for preventing respiratory tract infection in children. Cochrane Database Syst Rev. 2006;4:CD004974. https://doi.org/10.1002/14651858.CD004974.pub2
Schopohl P, Melzig MF. The influence of toll-like receptor (TLR-) agonists on lysozyme activity, TNF-alpha secretion and intercellular adhesion in THP-1 cells. Die Pharmazie-An International Journal of Pharmaceutical Sciences. 2014;69(8):602-609. https://doi.org/10.1691/ph.2014.4523
Coviello S, Wimmenauer V, Polack FP, Irusta PM. Bacterial lysates improve the protective antibody response against respiratory viruses through Toll-like receptor 4. Human Vaccines & Immunotherapeutics. 2014;10(10):2896-2902. https://doi.org/10.4161/hv.29784
Kearney SC, Dziekiewicz M, Feleszko W. Immunoregulatory and immunostimulatory responses of bacterial lysates in respiratory infections and asthma. Annals of Allergy, Asthma & Immunology. 2015;114(5):364-369. https://doi.org/10.1016/j.anai.2015.02.008
Karaulov AV. Immunomodulators for prevention and treatment of respiratory infections in children. Farmateka. 2012;1:43-47. Accessed October 15, 2024. (In Russ.). https://pharmateca.ru/en/archive/article/8334
Garashchenko TI, Il’enko LI, Garashchenko MV. Profilakticheskoe primenenie Imudona u chasto i dlitel’no boleyushchikh shkol’nikov. Voprosy sovremennoi pediatrii. 2002;1(5):27-30. (In Russ.).
Drozdova MV, Timofeeva GI, Tyrnova EV, Polevshchikov AV, Ryazancev SV. Otsenka posledstvii mestnoi immunomodulyatsii preparatom Imudon v klinike khronicheskogo tonzillita u detei. Lechenie i profilaktika vospalitel’nykh zabolevanii slizistoi obolochki polosti rta i glotki u detei. M.; 2002. (In Russ.).
Markova TP, Chuvirov DG. Kliniko–immunologicheskoe obosnovanie primeneniya preparata Imudon u dlitel’no i chasto boleyushchikh detei. Detskii doktor. 2001;3:23-26. (In Russ.).
Daniel A, Rezki A. Effect of local immunotherapy on the production of secretory salivary immunoglobulins in gingival inflammation. L’Information dentaire. 1989;71(30):2609-2612.
Karaulov AV, Likov VF. Immunoterapiya respiratornykh zabolevanii. Rukovodstvo dlya vrachei. M.: izdatel’stvo otdeleniya RAEN «Lekarstva i pishchevye dobavki»; 2004. (In Russ.).
Namazova LS, Botvin’eva VV, Torshkhoeva RM. Chasto boleyushchie deti megapolisov; lechenie i profilaktika ostrykh respiratornykh infektsii. Pediatricheskaya farmakologiya. 2005;2(1):3-7. (In Russ.).
Luchikhin LA, Mal’chenko OV. Effektivnost’ preparata Imudon v lechenii bol’nykh s ostrymi i khronicheskimi vospalitel’nymi zabolevaniyami glotki. Vestnik otorinolaringologii. 2001;3:62-64. (In Russ.).
Garashchenko TI, Garashchenko MV, Ovechkina NV, Kats TG. Kliniko-immunologicheskaya effektivnost’ Imudona u chasto i dlitel’no boleyushchikh detei s patologiei limfoglotochnogo kol’tsa. Pediatriya. 2009;86(5):98-104. (In Russ.).
Sergeev YuV, Karaulov AV. Immunokorrigiruyushchaya terapiya pri infektsionnykh porazheniyakh polosti rta. Lechashchii vrach. 2000;4:54-55. Accessed October 15, 2024. (In Russ.). https://www.lvrach.ru/2000/04/4525954
Soldatsky YuL, Onufrieva EK, Gasparyan SF, Pogosova IE. Effectiveness of Imudon topical immune therapy in complex treatment of acute laryngitis in children. Current Pediatrics. 2005;5:70-72. (In Russ.).
Kalyuzhin OV. Topical bacterial lysates in the prevention and treatment of respiratory infections. Practical Medicine. 2016;2(2):69-74. (In Russ.).
Kladova OV, Kornyushin MA, Legkova TP, Ryzhova EA, Zemskova LA, Butakova EP, Bazanova AS, Zamahina EV, Uchajkin VF. Clinical efficacy of Imudon in patients with tonsillopharyngitison the background of acute respiratory diseases. Detskie infektsii. 2005;4(1):53-57. (In Russ.).
Drozdova MV, Preobrazhenskaya YuS, Ryazantsev SV, Pavlova SS. Inflammatory diseases of the pharynx in children. Meditsinskiy Sovet. 2022;1:51-57. (In Russ.). https://doi.org/10.21518/2079-701X-2022-16-1-51-57
Bulgakova VA, Balabolkin II, Sentsova T, Katosova LB, Ryleeva IK, Yukhtina NV, Bashilova NV. Topical immunotropic agents in treatment. Pediatricheskaya farmakologiya. 2006;3(4):56-62. Accessed October 15, 2024. (In Russ.). https://www.pedpharma.ru/jour/article/view/582
Sentsova TB, Balabolkin II, Bulgakova VA, Korotkova TN, Ryleeva IV. Clinical and immunological effectiveness of Imudon in infectious stomatitis in children with atopic diseases. Voprosy sovremennoi pediatrii. 2004;3(2):69-72. (In Russ.).