The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 101-59-87
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2024
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Karpova E.P.

Tulupov D.A.

Russian Medical Academy for Continuous Professional Education

Gulieva A.P.

Russian Medical Academy of Continuous Professional Education

Dolginov D.M.

Children’s City Clinical Hospital named after. N.F. Filatov Department of Health of the City of Moscow

Kovalenko L.A.

Filatov Children’s City Clinical Hospital;
Russian Medical Academy for Continuous Professional Education

Grabovskaya V.A.

Children’s City Clinical Hospital named after. N.F. Filatov Department of Health of the City of Moscow

Dostiev V.F.

Children’s City Clinical Hospital named after. N.F. Filatov Department of Health of the City of Moscow

The frequency of adverse events associated with the use of nasal decongestants in children during the COVID-19 pandemic (2019—2020)

Authors:

Karpova E.P., Tulupov D.A., Gulieva A.P., Dolginov D.M., Kovalenko L.A., Grabovskaya V.A., Dostiev V.F.

More about the authors

Journal: Russian Rhinology. 2022;30(4): 261‑266

DOI: 10.17116/rosrino202230041261

Views: 914

Downloaded: 17

Download PDF (RU)
Contact the author
Table of contents

To cite this article:

Karpova EP, Tulupov DA, Gulieva AP, Dolginov DM, Kovalenko LA, Grabovskaya VA, Dostiev VF. The frequency of adverse events associated with the use of nasal decongestants in children during the COVID-19 pandemic (2019—2020). Russian Rhinology. 2022;30(4):261‑266. (In Russ.)
https://doi.org/10.17116/rosrino202230041261

Подписка 2025 (Russian Rhinology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Mediasphera_Net
Close metadata
Recommended articles:
Morphology of the myocardium of the inte­rventricular septum in children with hype­rtrophic cardiomyopathy. Russian Journal of Archive of Pathology. 2023;(6):5-15
SARS-CoV-2-induced non-bacterial endo­myocarditis with the deve­lopment of acquired heart defe­cts. Russian Journal of Archive of Pathology. 2023;(6):52-61
Medi­cal reha­bilitation of children with obstructive uropathy. Problems of Balneology, Physiotherapy and Exercise Therapy. 2023;(5):21-26
Alopecia and COVID-19: possible etiopathogenetic variants and therapeutic approach. Problems of Balneology, Physiotherapy and Exercise Therapy. 2023;(5):56-63
Medi­cal reha­bilitation features of patients suffered from new coro­navirus infe­ction. Problems of Balneology, Physiotherapy and Exercise Therapy. 2023;(5):64-69
New coro­navirus infe­ction in the II trimester of pregnancy: peri­natal and mate­rnal consequences. Russian Bulletin of Obstetrician-Gynecologist. 2023;(6):34-41
Type 2 diabetes mellitus and COVID-19: lethality predictors. Russian Journal of Preventive Medi­cine. 2023;(11):53-56
Symptoms in the SARS-CoV-2 survivors with critical lung damage (CT-4). Russian Journal of Preventive Medi­cine. 2023;(11):69-77
Left ventricular thro­mbosis and acute heart failure in patients after SARS-CoV-2 infe­ction. Russian Journal of Preventive Medi­cine. 2023;(11):78-81
Histological evaluation of esophageal stri­cture in children with caustic burn. Piro­gov Russian Journal of Surgery. 2023;(12):43-51

Adverse effects caused by the use of nasal vasoconstrictor drugs are not uncommon in pediatric practice. Nasal decongestant poisoning is one of the most common causes of hospitalization of preschool children in the toxicology department. The restrictive sanitary and epidemiological measures introduced during the COVID-19 pandemic significantly reduced the incidence of acute respiratory infections, which could have affected both the frequency of using vasoconstrictors and the frequency of adverse events caused by the nasal decongestants usage.

PURPOSE OF THE STUDY

To study the impact of restrictive sanitary and epidemiological measures on the proportion of complications due to the nasal vasoconstrictor drugs usage in the structure of toxicological pathology of a multidisciplinary hospital.

PATIENTS AND METHODS

A retrospective data analysis of patients medical records of the toxicology department and annual reports was carried out. The number of hospitalized patients with poisoning by decongestants, the age of patients, the active substance of the drug, the features of the use of the drug, which probably influenced the development of the side effect, were taken into account. The results were compared with similar data obtained in the period before the COVID-19 pandemic.

RESULTS

A clear trend towards a decrease in the absolute number of children with nasal decongestant poisoning was revealed. The greatest risk of poisoning with nasal vasoconstrictor drugs falls on the age group of children from 1 year to 3 years. In more than 75% of cases, complications occurred with the use of naphazoline drugs. In most episodes, the poisoning mechanism was not associated with medical prescriptions, but was a consequence of the decisions of the child’s parents.

CONCLUSION

To reduce the risks of developing adverse events associated with the action of nasal decongestants, it is necessary to strictly follow the regimen for the use of the drug indicated in its instructions, not to exceed a single dose and frequency of use. Also, the use of drugs based on naphazoline should be avoided due to their greatest child toxicity.

Keywords:

children
nasal vasoconstrictors
naphazoline
COVID-19
SARS-CoV-2

Authors:

Karpova E.P.

Tulupov D.A.

Russian Medical Academy for Continuous Professional Education

Gulieva A.P.

Russian Medical Academy of Continuous Professional Education

Dolginov D.M.

Children’s City Clinical Hospital named after. N.F. Filatov Department of Health of the City of Moscow

Kovalenko L.A.

Filatov Children’s City Clinical Hospital;
Russian Medical Academy for Continuous Professional Education

Grabovskaya V.A.

Children’s City Clinical Hospital named after. N.F. Filatov Department of Health of the City of Moscow

Dostiev V.F.

Children’s City Clinical Hospital named after. N.F. Filatov Department of Health of the City of Moscow

Received:

14.05.2022

Accepted:

10.07.2022

List of references:

  1. Smith MM, Ishman SL. Pediatric Nasal Obstruction. Otolaryngol Clin North Am. 2018;51(5):971-985.  https://doi.org/10.1016/j.otc.2018.05.005
  2. Dykewicz MS, Wallace DV, Amrol DJ, Baroody FM, Bernstein JA, Craig TJ, Dinakar C, Ellis AK, Finegold I, Golden DBK, Greenhawt MJ, Hagan JB, Horner CC, Khan DA, Lang DM, Larenas-Linnemann DES, Lieberman JA, Meltzer EO, Oppenheimer JJ, Rank MA, Shaker MS, Shaw JL, Steven GC, Stukus DR, Wang J; Chief Editor(s): Dykewicz MS, Wallace DV; Joint Task Force on Practice Parameters: Dinakar C, Ellis AK, Golden DBK, Greenhawt MJ, Horner CC, Khan DA, Lang DM, Lieberman JA, Oppenheimer JJ, Rank MA, Shaker MS, Stukus DR, Wang J; Workgroup Contributors: Dykewicz MS, Wallace DV, Amrol DJ, Baroody FM, Bernstein JA, Craig TJ, Finegold I, Hagan JB, Larenas-Linnemann DES, Meltzer EO, Shaw JL, Steven GC. Rhinitis 2020: A practice parameter update. J Allergy Clin Immunol. 2020;146(4):721-767.  https://doi.org/10.1016/j.jaci.2020.07.007
  3. Trabalon M, Schaal B. It takes a mouth to eat and a nose to breathe: abnormal oral respiration affects neonates’ oral competence and systemic adaptation. Int J Pediatr. 2012;2012:207605. https://doi.org/10.1155/2012/207605
  4. Leboulanger N. Nasal obstruction in children. Eur Ann Otorhinolaryngol Head Neck Dis. 2016;133(3):183-186.  https://doi.org/10.1016/j.anorl.2015.09.011
  5. Baranov AA, Lobzin YuV, Namazova-Baranova LS, Tatochenko VK, i soavt. Ostraya respiratornaya virusnaya infekciya (ORVI). Klinicheskie rekomendacii (proekt). 2020. Accessed September 26, 2022. (In Russ.). https://www.pediatr-russia.ru/information/klin-rek/proekty-klinicheskikh-rekomendatsiy/ОРВИ%20дети%20СПР.v1_2019%20-%20финал.pdf
  6. Karneeva OV, Gurov AV, Karpova EP, Tulupov DA, Ryazancev SV, Garashchenko TI, Polyakov DP, Kim IA. Ostryj sinusit. Klinicheskie rekomendacii. Minzdrav Rossii. M. 2021. Accessed September 26, 2022. (In Russ.). https://cr.minzdrav.gov.ru/schema/313_2
  7. Geppe NA, Karpova EP, Dronov IA, Abdulkerimov HT, Arhipov VV, Vavilova VP, Garashchenko TI, Gurov AV, Dronov IA, Drynov GI, Il’enkova NA, Il’enko LI, Karpova EP, Kiselev AB, Kolosova NG, Kondyurina EG, Malahov AB, Nikiforova GN, Radcig EYu, Revyakina VA, Ryazancev SV, Svistushkin VM, Tulupov DA, Car’kova SA, Chebotareva TA. Konsensus po zatrudnennomu dyhaniyu u detej. Nazal’naya obstrukciya mul’tidisciplinarnaya problema. Rezolyuciya soveta ekspertov. Voprosy prakticheskoy pediatrii. 2021;16(6):149-160. (In Russ.). https://doi.org/10.20953/1817-7646-2021-6-149-160
  8. Tulupov DA, Fedotov FA, Karpova EP, Grabovskaya VA. Sovremennye aspekty primeneniya nazal’nyh sosudosuzhivayushchih i vspomogatel’nyh preparatov v pediatricheskoj praktike. Medicinskij Sovet. 2018;2:114-117. (In Russ.). https://doi.org/10.21518/2079-701X-2018-2-114-117
  9. Karneeva OV, Gurov AV, Polyakov DP, Tulupov DA, i soavt. Ostryj srednij otit. Klinicheskie rekomendacii. Nacional’naya medicinskaya associaciya otorinolaringologov. M. 2021. Accessed September 26, 2022. (In Russ.). https://cr.minzdrav.gov.ru/recomend/314_2
  10. Nosulya EV. Medikamentoznyj rinit. Vestnik otorinolaringologii. 2017;82(3):84-90. (In Russ.). https://doi.org/10.17116/otorino201782384-90
  11. Varvianskaia AV, Lopatin AS. Topical nasal decongestants: Comparative characteristics and a review of side effects. Rossiyskaya rinologiya. 2015;23(4):50-56. (In Russ.). https://doi.org/10.17116/rosrino201523450-56
  12. Alvarez-Pitti J, Rodríguez-Varela A, Morales-Carpi C, Lurbe E, Estañ L. Naphazoline intoxication in children. Eur J Pediatr. 2006;165(11):815-816.  https://doi.org/10.1007/s00431-006-0185-1
  13. Tulupov DA, Karpova EP. About safety of use of nasal decongestant in practice of pediatricians. Rossiyskaya rinologiya. 2014;1:12-14. (In Russ.).
  14. Karpova EP, Tulupov DA, Vorob’eva MP, Fedotov FA, Dolginov DM, Bykov MV, Grabovskaya VA. About the safety of application of nasal decongestants in the practice of pediatricians. Vestnik otorinolaringologii. 2018;83(2):46-50. (In Russ.). https://doi.org/10.17116/otorino201883246-50
  15. Torretta S, Capaccio P, Coro I, Bosis S, Pace ME, Bosi P, Pignataro L, Marchisio P. Incidental lowering of otitis-media complaints in otitis-prone children during COVID-19 pandemic: not all evil comes to hurt. Eur J Pediatr. 2021;180(2):649-652.  https://doi.org/10.1007/s00431-020-03747-9
  16. Zimmermann P, Curtis N. Coronavirus Infections in Children Including COVID-19: An Overview of the Epidemiology, Clinical Features, Diagnosis, Treatment and Prevention Options in Children. Pediatr Infect Dis J. 2020;39(5):355-368.  https://doi.org/10.1097/INF.0000000000002660
  17. Miller LE, Bhattacharyya N. Antibiotic Prescribing for Acute Rhinosinusitis: In-Person Versus Virtual Visits During Covid-19. Laryngoscope. 2021;131(7):2121-2124. https://doi.org/10.1002/lary.29323
  18. Nikolaeva SV, Usenko DV, Shabalina SV, Khlypovka YuN, Gorelov AV. Mono- and mixed respiratory tract infections in children: relevance of the problem during the COVID-19 pandemics. Infectious diseases. 2021;19(1): 135-138. (In Russ.). https://doi.org/10.20953/1729-9225-2021-1-135-138

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register


We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.