Efficacy and potential of olopatadine-mometasone combination nasal spray for the treatment of allergic rhinitis

The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Search result: 0

Nosulya E.V.

Sverzhevky Research Clinical Institute of Otorhinolaryngology

ORCID: 0000-0002-3897-8384

Kunelskaya V.Ya.

L.I. Sverzhevskiy Research Institute of Clinical Otorhinolaryngology

ORCID: 0000-0001-5640-6833

Kim I.A.

N.I. Pirogov Russian National Research Medical University;
National Medical Research Center of Otorhinolaryngology of Federal Medical-Biological Agency

ORCID: 0000-0003-1078-6388

Luchsheva Yu.V.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology

ORCID: 0000-0002-8412-710X

Kozulina I.E.

LLC "GUTA-CLINIC"

Efficacy and potential of olopatadine-mometasone combination nasal spray for the treatment of allergic rhinitis

Authors:

Nosulya E.V., Kunelskaya V.Ya., Kim I.A., Luchsheva Yu.V., Kozulina I.E.

More about the authors

Journal: Russian Rhinology. 2021;29(3): 167‑172

DOI: 10.17116/rosrino202129031167

Read: 5091 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Nosulya EV, Kunelskaya VYa, Kim IA, Luchsheva YuV, Kozulina IE. Efficacy and potential of olopatadine-mometasone combination nasal spray for the treatment of allergic rhinitis. Russian Rhinology. 2021;29(3):167‑172. (In Russ.)
https://doi.org/10.17116/rosrino202129031167

Подписка 2026 Российская ринология (Russian Rhinology)

Использование инфографики авторами научных работ

Close metadata

Recommended articles:

A Randomized Controlled Trial Comparing Budesonide and Mometasone Furoate Nasal Spray in the Treatment of Chronic Rhinosinusitis with Nasal Polyposis: Evaluating Symptom Scores and Quality of Life. Russian Rhinology. 2025;(1):12-17

Differentiated approach to the choice of agents for pathogenetic drug therapy in patients with allergic rhinitis. Russian Rhinology. 2025;(1):18-26

Efficacy and safety of mometasone and olopatadine combination for nasal use in patients with allergic rhinitis caused by sensitization to epidermal allergens in continuous exposure. Russian Rhinology. 2025;(1):48-56

Influence of age and sex on values of SNOT-22 sinonasal test domains in children and adolescents with bronchial asthma. Russian Rhinology. 2025;(3):197-204

Comparative analysis of the effectiveness of treatment for exudative otitis media and eustachitis associated with concomitant allergic rhinitis. Russian Bulletin of Otorhinolaryngology. 2025;(5):48-55

Possibilities of combined physiotherapy treatment of allergic rhinitis. Russian Bulletin of Otorhinolaryngology. 2025;(6):72-76

Abstract:

OBJECTIVE

To summarize the current data concerning the efficacy, safety, and potential for use of a fixed combination nasal spray of olopatadine hydrochloride (665 mcg) and mometasone furoate (25 mcg) in allergic rhinitis.

DATA SOURCES

The materials from the Web of Science, Russian Science Citation Index, and PubMed databases were reviewed. The search was performed by keywords: allergic rhinitis, olopatadine hydrochloride, mometasone furoate.

RESULTS

Analysis of the published clinical trials results demonstrates the value and benefits of the fixed combination of intranasal glucocorticosteroid (mometasone furoate) and intranasal antihistamine drug (olopatadine hydrochloride) (GSP 301) in allergic rhinitis. The components of the drug product (olopatadine hydrochloride and mometasone furoate) provide rapid and pronounced relief of the AR symptoms during the entire treatment course.

CONCLUSION

The therapeutic efficacy and good safety profile of the drug product warrant its use as the drug of choice in allergic rhinitis.

Keywords:

allergic rhinitis

olopatadine hydrochloride

mometasone furoate

Authors:

Nosulya E.V.

Sverzhevky Research Clinical Institute of Otorhinolaryngology

ORCID: 0000-0002-3897-8384

Kunelskaya V.Ya.

L.I. Sverzhevskiy Research Institute of Clinical Otorhinolaryngology

ORCID: 0000-0001-5640-6833

Kim I.A.

N.I. Pirogov Russian National Research Medical University;
National Medical Research Center of Otorhinolaryngology of Federal Medical-Biological Agency

ORCID: 0000-0003-1078-6388

Luchsheva Yu.V.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology

ORCID: 0000-0002-8412-710X

Kozulina I.E.

LLC "GUTA-CLINIC"

Received:

07.08.2021

Accepted:

17.08.2021

Close metadata

References:

Tan BK, Chandra RK, Pollak J, Kato A, Conley DB, Peters AT, Grammer LC, Avila PC, Kern RC, Stewart WF, Schleimer RP, Schwartz BS. Incidence and associated premorbid diagnoses of patients with chronic rhinosinusitis. The Journal of Allergy and Clinical Immunology. 2013;131(5):1350-1360. https://doi.org/10.1016/j.jaci.2013.02.002
Emanuel IA, Shah SB. Chronic rhinosinusitis: allergy and sinus computed tomography relationships. Otolaryngology–Head and Neck Surgery. 2000;123(6):687-691. https://doi.org/10.1067/mhn.2000.110961
Sedaghat AR, Phipatanakul W, Cunningham MJ. Characterization of aeroallergen sensitivities in children with allergic rhinitis and chronic rhinosinusitis. Allergy & Rhinology (Providence). 2014;5:143-145.
Gutman M, Torres A, Keen KJ, Houser SM. Prevalence of allergy in patients with chronic rhinosinusitis. Otolaryngology–Head and Neck Surgery. 2004;130:545-552.
Hoover GE, Newman LJ, Platts-Mills TA, Phillips CD, Gross CW, Wheatley LM. Chronic sinusitis: Risk factors for extensive disease. The Journal of Allergy and Clinical Immunology. 1997;100(2):185-191. https://doi.org/10.1016/s0091-6749(97)70223-9
Newman LJ, Platts-Mills TA, Phillips CD, Hazen KC, Gross CW. Chronic sinusitis. Relationship of computed tomographic findings to allergy, asthma, and eosinophilia. Journal of the American Medical Association. 1994;271(5):363-367.
DeYoung K, Wentzel JL, Schlosser RJ, Nguyen SA, Soler ZM. Systematic review of immunotherapy for chronic rhinosinusitis. The American Journal of Rhinology & Allergy. 2014;28(2):145-150. https://doi.org/10.2500/ajra.2014.28.4019
Khan DA. Allergic rhinitis and asthma: epidemiology and common pathophysiology. Allergy and Asthma Proceedings. 2014;35(5):357-361. https://doi.org/10.2500/aap.2014.35.3794
Meltzer EO, Szwarcberg J, Pill MW. Allergic rhinitis, asthma, and rhinosinusitis: diseases of the integrated airway. Journal of Managed Care & Specialty Pharmacy. 2004;10(4):310-317. https://doi.org/10.18553/jmcp.2004.10.4.310
Sadeghi-Shabestari M, Jabbari Moghaddam Y, Ghaharri H. Is there any correlation between allergy and adenotonsillar tissue hypertrophy? International Journal of Pediatric Otorhinolaryngology. 2011;75(4):589-591. https://doi.org/10.1016/j.ijporl.2011.01.026
Cho KS, Kim SH, Hong SL, Lee J, Mun SJ, Roh YE, Kim YM, Kim HY. Local Atopy in Childhood Adenotonsillar Hypertrophy. The American Journal of Rhinology & Allergy. 2018;32(3):160-166. https://doi.org/10.1177/1945892418765003
Olusesi AD, Undie NB, Amodu JE. Allergy history as a predictor of early onset adenoids/adenotonsillar hypertrophy among Nigerian children. International Journal of Pediatric Otorhinolaryngology. 2013;77(6):1032-1035. https://doi.org/10.1016/j.ijporl.2013.04.004
Lee DJ, Chung YJ, Yang YJ, Mo JH. The Impact of Allergic Rhinitis on Symptom Improvement in Pediatric Patients After Adenotonsillectomy. Clinical and Experimental Otorhinolaryngology. 2018;11(1):52-57. https://doi.org/10.21053/ceo.2017.00500
Mariño-Sánchez F, Valls-Mateus M, Cardenas-Escalante P, Haag O, Ruiz-Echevarría K, Jiménez-Feijoo R, Lozano-Blasco J, Giner-Muñoz MT, Plaza-Martin AM, Mullol J. Influence of nasal septum deformity on nasal obstruction, disease severity, and medical treatment response among children and adolescents with persistent allergic rhinitis. International Journal of Pediatric Otorhinolaryngology. 2017;95:145-154. https://doi.org/10.1016/j.ijporl.2017.02.005
Karatzanis AD, Fragiadakis G, Moshandrea J, Zenk J, Iro H, Velegrakis GA. Septoplasty outcome in patients with and without allergic rhinitis. Rhinology. 2009;47(4):444-449. https://doi.org/10.4193/Rhin08.126
Kim DH, Kim BY, Shin JH, Kim SW, Kim SW. Intranasal azelastine and mometasone exhibit a synergistic effect on a murine model of allergic rhinitis. American Journal of Otolaryngology. 2017;38(2):198-203. https://doi.org/10.1016/j.amjoto.2017.01.008
Berdnikova NG, Blohin BM, Garashchenko TI, Geppe NA, Kim IA, Nenasheva NM, Nosulya EV, Ovchinnikov AYu, Ryazancev SV, Svistushkin VM, Fedoskova TG. Rezolyuciya ekspertnogo soveta. Mesto preparatov Momat Rino (mometazon) i Momat Rino Advans (azelastin + mometazon) v terapii allergicheskogo rinita srednej/tyazheloj stepeni tyazhesti v ambulatornoj praktike. Consilium Medicum. 2017;19(3):40-43. (In Russ.).
Nosulya EV, Kim IA. Sovremennye topicheskie preparaty v stupenchatoj terapii allergicheskogo rinita. Vestnik otorinolaringologii. 2017;2:65-69. (In Russ.). https://doi.org/10.17116/otorino201782265-69
Meltzer EO. Pharmacotherapeutic strategies for allergic rhinitis: matching treatment to symptoms, disease progression, and associated conditions. Allergy and Asthma Proceedings. 2013;34(4):301-311. https://doi.org/10.2500/aap.2013.34.3676
Nenasheva NM. Lechenie allergicheskogo rinita s pozicii novyh mezhdunarodnyh rukovodstv: rol’ topicheskoj kombinirovannoj terapii. Effektivnaya farmakoterapiya. 2018;6:40-48. Accessed August 10, 2021. (In Russ.). https://umedp.ru/articles/lechenie_allergicheskogo_rinita_s_pozitsii_novykh_mezhdunarodnykh_rukovodstv_rol_topicheskoy_kombini.html
Hampel FC, Pedinoff AJ, Jacobs RL, Caracta CF, Tantry SK. Olopatadine-mometasone combination nasal spray: Evaluation of efficacy and safety in patients with seasonal allergic rhinitis. Allergy and Asthma Proceedings. 2019;40(4):261-272. https://doi.org/10.2500/aap.2019.40.4223
Gross GN, Berman G, Amar NJ, Caracta CF, Tantry SK. Efficacy and safety of olopatadine-mometasone combination nasal spray for the treatment of seasonal allergic rhinitis. Annals of Allergy, Asthma & Immunology. 2019;122(6):630-638. https://doi.org/10.1016/j.anai.2019.03.017
Andrews CP, Mohar D, Salhi Y, Tantry SK. Efficacy and safety of twice-daily and once-daily olopatadine-mometasone combination nasal spray for seasonal allergic rhinitis. Annals of Allergy, Asthma & Immunology. 2020;124(2):171-178. https://doi.org/10.1016/j.anai.2019.11.007
Segall N, Prenner B, Lumry W, Caracta CF, Tantry SK. Long-term safety and efficacy of olopatadine-mometasone combination nasal spray in patients with perennial allergic rhinitis. Allergy and Asthma Proceedings. 2019;40(5):301-310. https://doi.org/10.2500/aap.2019.40.4233
Patel P, Salapatek AM, Talluri RS, Tantry SK. Pharmacokinetics of intranasal mometasone in the fixed-dose combination GSP 301 versus two monotherapy intranasal mometasone formulations. Allergy and Asthma Proceedings. 2018;39(3):232-239. https://doi.org/10.2500/aap.2018.39.4134
Nenasheva NM, Nazarova EV, Terekhova EP, Sebekina OV, Peredel’skaya MYu, Bitieva EA. Effektivnost’ i bezopasnost’ kombinirovannogo preparata GSP 301 NS u pacientov s sezonnym allergicheskim rinitom:rezul’taty mnogocentrovogo randomizirovannogo otkrytogo klinicheskogo issledovaniya. Prakticheskaya allergologiya. 2021;1:66-77. (In Russ.).
Meltzer EO. Allergic Rhinitis: Burden of Illness, Quality of Life, Comorbidities, and Control. Immunology and Allergy Clinics of North America. 2016;36(2):235-248. https://doi.org/10.1016/j.iac.2015.12.002
Astaf’eva NG, Baranov AA, Vishneva EA, Dajhes NA, Zhestkov AV, Il’ina NI, Karneeva OV, Karpova EP, Kim IA, Kryukov AI, Kurbacheva OM, Meshkova RYa, Namazova-Baranova LS, Nenasheva NM, Novik GA, Nosulya EV, Pavlova KS, Pampura AN, Svistushkin VM, Selimzyanova LR, Haitov MR, Haitov RM. Allergicheskij rinit. Rossijskaya rinologiya. 2020;28(4):246-256. (In Russ.). https://doi.org/10.17116/rosrino202028041246
Carr W, Bernstein J, Lieberman P, Meltzer E, Bachert C, Price D, Munzel U, Bousquet J. A novel intranasal therapy of azelastine with fluticasone for the treatment of allergic rhinitis. The Journal of Allergy and Clinical Immunology. 2012;129(5):1282-1289. https://doi.org/10.1016/j.jaci.2012.01.077
Nenasheva NM, Il’ina NI, Fedoskova TG. Effektivnost’ sovmestnogo primeneniya intranazal’nogo kortikosteroida i antigistaminnogo preparata u vzroslyh bol’nyh sezonnym allergicheskim rinitom na primere fiksirovannoj kombinacii mometazona furoata i azelastina gidrohlorida v vide nazal’nogo spreya (rezul’taty klinicheskogo issledovaniya). Rossijskij allergologicheskij zhurnal. 2016;2:54-62. (In Russ.).

Log in to the site using your account in one of the services

Registration

Last Name

Name

Middle Name

E-mail

Phone

Address

Country

Zip

City

Region

Street

Home

Apartmen

Legal entity name

ИНН

КПП

Password

Password

Repeat password

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.