Distant outcomes in patients suffered from COVID-19 with extremely severe lung damage (CT grade 4)

Komissarova K.V.

O.M. Filatov City Clinical Hospital No. 15;
Pirogov Russian National Research Medical University

ORCID: 0009-0000-4277-3456

Godzenko A.V.

O.M. Filatov City Clinical Hospital No. 15

Doroshenko D.A.

O.M. Filatov City Clinical Hospital No. 15;
Pirogov Russian National Research Medical University

SPIN RSCI: 9451-7029
Scopus AuthorID: 6506309334
ResearcherID: C-7826-2016
ORCID: 0000-0001-8045-1423

Gordeev I.G.

O.M. Filatov City Clinical Hospital No. 15;
Pirogov Russian National Research Medical University

ORCID: 0000-0002-3233-4369

Averkov O.V.

O.M. Filatov City Clinical Hospital No. 15;
Pirogov Russian National Research Medical University

ORCID: 0000-0002-3010-755X

Vechorko V.I.

O.M. Filatov City Clinical Hospital No. 15;
Pirogov Russian National Research Medical University

ORCID: 0000-0003-3568-5065

Gildeeva G.N.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0002-2537-2850

Distant outcomes in patients suffered from COVID-19 with extremely severe lung damage (CT grade 4)

Authors:

Komissarova K.V., Godzenko A.V., Doroshenko D.A., Gordeev I.G., Averkov O.V., Vechorko V.I., Gildeeva G.N.

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Journal: Russian Journal of Preventive Medicine. 2023;26(10): 55‑61

DOI: 10.17116/profmed20232610155

Downloaded: 48

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To cite this article:

Komissarova KV, Godzenko AV, Doroshenko DA, Gordeev IG, Averkov OV, Vechorko VI, Gildeeva GN. Distant outcomes in patients suffered from COVID-19 with extremely severe lung damage (CT grade 4). Russian Journal of Preventive Medicine. 2023;26(10):55‑61. (In Russ.)
https://doi.org/10.17116/profmed20232610155

Подписка 2025 (Russian Journal of Preventive Medicine)

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OBJECTIVE

To assess the long-term outcomes in patients suffered from novel coronavirus infection (COVID-19) with total lung damage (CT 4 grade) and to search for factors impacting on outcomes.

MATERIAL AND METHODS

The outcomes of 341 patients (173 (60.7%) women and 168 (39.3%) men; age median was 63 (53-71) years), who were treated in Filatov City Clinical Hospital №15 regarding 4 grade CT lung damage caused by SARS-CoV-2, were assessed after 6 and 12 months of hospital discharge, in the periods from 04.04.2020 to 01.07.2020, from 01.10.2020 to 22.01.2021 and from 15.06.2021 to 28.08.2021. The data of survived (289) and deceased (52) patients were compared by demographic parameters, comorbid pathology, clinical features of the disease obtained from the medical history in retrospective phase of the study.

RESULTS

The proportion of patients equal 84.8% (95% CI 80.5-88.4) were alive at six-month point. After 12 months, 100% of patients were alive. In most cases the mortality occurred during 45 days after hospital discharge (35 cases; 70.0% (95% CI 55.4-82.1)). The factors associated with mortality after 6 months were age, comorbidity and grade of CT at admission to the hospital.

CONCLUSION

The mortality rate after 12 months of hospital discharge was 15.2%. Increase of mortality rate during 45 days after hospital discharge and analysis of death causes demonstrate the need for post-hospital monitoring of patients with 4 grade CT, especially those with risk factors.

Keywords:

novel coronavirus infection

SARS-CoV-2

COVID-19

extremely severe course

4 grade CT

distant outcomes

prospective observation

Authors:

Komissarova K.V.

O.M. Filatov City Clinical Hospital No. 15;
Pirogov Russian National Research Medical University

ORCID: 0009-0000-4277-3456

Godzenko A.V.

O.M. Filatov City Clinical Hospital No. 15

Doroshenko D.A.

O.M. Filatov City Clinical Hospital No. 15;
Pirogov Russian National Research Medical University

SPIN RSCI: 9451-7029
Scopus AuthorID: 6506309334
ResearcherID: C-7826-2016
ORCID: 0000-0001-8045-1423

Gordeev I.G.

O.M. Filatov City Clinical Hospital No. 15;
Pirogov Russian National Research Medical University

ORCID: 0000-0002-3233-4369

Averkov O.V.

O.M. Filatov City Clinical Hospital No. 15;
Pirogov Russian National Research Medical University

ORCID: 0000-0002-3010-755X

Vechorko V.I.

O.M. Filatov City Clinical Hospital No. 15;
Pirogov Russian National Research Medical University

ORCID: 0000-0003-3568-5065

Gildeeva G.N.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0002-2537-2850

Received:

26.06.2023

Accepted:

11.08.2023

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