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Strakhova L.A.

Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology

Blinova T.V.

Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology

Ivanova Yu.V.

Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology

Rudoy M.D.

Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology

Troshin V.V.

Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology

Biomarkers of endothelial dysfunction in workers exposed to industrial noise

Authors:

Strakhova L.A., Blinova T.V., Ivanova Yu.V., Rudoy M.D., Troshin V.V.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2022;25(5): 93‑100

DOI: 10.17116/profmed20222505193

Read: 824 times

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Table of contents

BIOMARKERS OF ENDOTHELIAL DYSFUNCTION IN WORKERS EXPOSED TO INDUSTRIAL NOISE
BIOMARKERS OF ENDOTHELIAL DYSFUNCTION IN WORKERS EXPOSED TO INDUSTRIAL NOISE

To cite this article:

Strakhova LA, Blinova TV, Ivanova YuV, Rudoy MD, Troshin VV. Biomarkers of endothelial dysfunction in workers exposed to industrial noise. Russian Journal of Preventive Medicine. 2022;25(5):93‑100. (In Russ.)
https://doi.org/10.17116/profmed20222505193

 
 
 
Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

PURPOSE OF THE STUDY

To assess the relationship between the levels of type 1 endothelin (ET-1) and total nitric oxide (NOx) metabolites and blood pressure (BP) in young and middle-aged people working in conditions of industrial noise exposure.

MATERIAL AND METHODS

Under observation were 120 workers of one of the metallurgical plants of the Nizhny Novgorod region — men aged 25 to 51 years old, who were exposed to industrial noise in the course of their work, as well as men (34 people aged 28 to 52 years old) working outside the impact harmful production factors. In blood serum, the concentration of ET-1 and the content of NOx were determined.

RESULTS

High levels of ET-1 in the blood serum and low levels of the NOx/ET-1 ratio were found in workers exposed to industrial noise with a high normal level of blood pressure and arterial hypertension.

CONCLUSION

Indicators of endothelial dysfunction type 1 endothelin and nitric oxide can be proposed for use as biomarkers of the risk of developing arterial hypertension in young and middle-aged people working in conditions of industrial noise exposure and for monitoring the state of the cardiovascular system during therapeutic and preventive measures., as well as in the development of new strategies for the prevention of cardiovascular diseases.

Keywords:

industrial noise
type 1 endothelin
nitric oxide
endothelial dysfunction
blood pressure
risk factor

Authors:

Strakhova L.A.

Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology

Blinova T.V.

Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology

Ivanova Yu.V.

Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology

Rudoy M.D.

Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology

Troshin V.V.

Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology

Received:

01.02.2022

Accepted:

15.03.2022

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References:

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