The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.
Anikin D.A.
Krasnoyarsk State Medical University named after Prof. V.F. Voyno-Yasenetsky;
Regional Clinical Hospital
Sobko E.A.
Krasnoyarsk State Medical University named after prof. V.F. Voyno-Yasenetsky;
Regional Clinical Hospital
Free radical oxidation in the pathogenesis of metabolic syndrome
Journal: Russian Journal of Preventive Medicine. 2022;25(11): 98‑104
Views: 1975
Downloaded: 53
To cite this article:
Anikin DA, Demko IV, Solovyeva IA, Sobko EA, Gordeeva NV, Kraposhina AYu. Free radical oxidation in the pathogenesis of metabolic syndrome. Russian Journal of Preventive Medicine.
2022;25(11):98‑104. (In Russ.)
https://doi.org/10.17116/profmed20222511198
A review of domestic and foreign studies on the role of oxidative stress in the pathogenesis of the metabolic syndrome is presented. It is noted that metabolic syndrome is one of the factors determining cardiovascular risk since oxidative stress results from excessive accumulation of lipid and carbohydrate metabolism products. Various aspects of the effect of reactive oxygen and nitrogen forms and other free radicals on oxidative stress development in disorders comprising the metabolic syndrome complex are addressed. Thus, the mechanisms of chronic inflammation due to excessive secretion of proinflammatory cytokines and adipokines, activation of the transcription factor NF-κB, and antioxidant system dysfunction in obesity are described. Some mechanisms of adipokines’ effect on oxidative stress are considered individually: leptin, adiponectin, chimerin, and omentin type 1. In addition, the review describes polyol pathway activation variants and diacyl-glycerol-protein kinase C-signaling pathway of oxidative stress and mitochondrial dysfunction resulting in excess free radical production in insulin resistance, diabetes mellitus, and its macro- and microvascular complications.
Authors:
Anikin D.A.
Krasnoyarsk State Medical University named after Prof. V.F. Voyno-Yasenetsky;
Regional Clinical Hospital
Sobko E.A.
Krasnoyarsk State Medical University named after prof. V.F. Voyno-Yasenetsky;
Regional Clinical Hospital
Received:
31.05.2022
Accepted:
06.09.2022
List of references:
Close metadata
Email Confirmation
An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.
Email Confirmation
Log in to the site using your account in one of the services
We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.