Phenotypes of vascular aging in young people in terms of their relationship with body mass index

Evsevyeva M.E.; Eremin M.V.; Rostovtseva M.V.; Fursova E.N.; Rusidi A.V.; Italyantseva E.V.; Kudryavtseva V.D.

doi:https://doi.org/10.17116/profmed20212403152

Evsevyeva M.E.

Stavropol State Medical University

Eremin M.V.

Stavropol Regional Clinical Hospital

Rostovtseva M.V.

Stavropol State Medical University

Fursova E.N.

Stavropol State Medical University

Rusidi A.V.

Stavropol State Medical University

Italyantseva E.V.

Stavropol State Medical University

Kudryavtseva V.D.

Stavropol State Medical University

Phenotypes of vascular aging in young people in terms of their relationship with body mass index

Authors:

Evsevyeva M.E., Eremin M.V., Rostovtseva M.V., Fursova E.N., Rusidi A.V., Italyantseva E.V., Kudryavtseva V.D.

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Journal: Russian Journal of Preventive Medicine. 2021;24(3): 52‑58

DOI: 10.17116/profmed20212403152

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To cite this article:

Evsevyeva ME, Eremin MV, Rostovtseva MV, Fursova EN, Rusidi AV, Italyantseva EV, Kudryavtseva VD. Phenotypes of vascular aging in young people in terms of their relationship with body mass index. Russian Journal of Preventive Medicine. 2021;24(3):52‑58. (In Russ.)
https://doi.org/10.17116/profmed20212403152

Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)

Использование инфографики авторами научных работ

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OBJECTIVE

Assess whether young people (YP) belong to different vascular phenotypes depending on body mass index (BMI) and gender.

MATERIAL AND METHODS

96 boys and 175 girls (271 YPs in total) aged 18 to 25 were examined at the health center of the StSMU. All YPs were divided into quartile groups for the vascular stiffness index, the cardiovascular vascular index (CAVI) which was determined using the VaSera-1500 diagnostic complex (Fukuda Denshi, Japan). According to the latest recommendations of international experts the fourth quartile of this distribution corresponds to premature vascular aging or early vascular aging syndrome; and the first quartile corresponds to favorable vascular aging. The representation of young carriers of overweight, normal and deficient body weight (BW) in each of the four CAVI quartiles was analyzed. Data processing was carried out using the Statistica 10.0 software package (StatSoft Inc., USA).

RESULTS

Most YPs with signs of overweight and obesity are presented in the lower two quartiles and the overwhelming majority of YPs with insufficient BM are in the upper two CAVI-quartile groups. Normal weight YPs were distributed evenly across CAVI-quartile groups. Gender differences were revealed among YPs in terms of predisposition to EVA syndrome and favorable vascular aging depending on height and weight characteristics.

CONCLUSION

It is useful to take into account the obtained data when conducting prophylactic medical examination of young people in order to form more differentiated groups of CV risk for further implementation of individualized programs of preventive interventions, taking into account the peculiarities assessment of vascular aging phenotype of each young person.

Keywords:

vascular aging phenotypes

youth

body mass index

Authors:

Evsevyeva M.E.

Stavropol State Medical University

Eremin M.V.

Stavropol Regional Clinical Hospital

Rostovtseva M.V.

Stavropol State Medical University

Fursova E.N.

Stavropol State Medical University

Rusidi A.V.

Stavropol State Medical University

Italyantseva E.V.

Stavropol State Medical University

Kudryavtseva V.D.

Stavropol State Medical University

Received:

18.05.2020

Accepted:

04.09.2020

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References:

Shlyakhto EV, Zvartau NE, Villevalde SV, Yakovlev AN, Solovieva AE, Alieva AS, Avdonina NG, Medvedeva EA, Fedorenko AA, Kulakov VV, Karlina VA, Endubaeva GV, Zaitsev VV, Soloviev AE. Cardiovascular risk management system: prerequisites for developing, organization principles, target groups. Russian Journal of Cardiology. 2019;11:69-82. (In Russ.). https://doi.org/10.15829/1560-4071-2019-11-69-82
Order of the Ministry of health of the Russian Federation of April 24, 2018 No. 186 “About approval of the concept of predictive, preventive and personalized medicine”. (In Russ.).
Golubnitschaja O, Baban B, Boniolo G, Wang W, Bubnov R, Kapalla M, Krapfenbauer K, Mozaffari MS, Costigliola V. Medicine in the early twenty-first century: paradigm and anticipation — EPMA position paper 2016. EPMA Journal. 2016;7(1):23-27. https://doi.org/10.1186/s13167-016-0072-4
Golubnitschaja O, Costigliola V, EPMA. General report & recommendations in predictive, preventive and personalised medicine 2012: white paper of the European association for predictive, preventive and personalized medicine. EPMAJournal. 2012;3(1):14-18. https://doi.org/10.1186/1878-5085-3-14
Evsevyeva ME, Kumukova ZV. Features of the psychological status of young people with signs of arterial hypertension. Russian Psychiatric Journal. 2007; 3:53-57. (In Russ.).
Nilsson PM. Early vascular ageingin translation: from laboratory investigations to clinical applications in cardiovascular prevention. J Hypertens. 2013; 31(8):1517-1526. https://doi.org/10.1097/HJH.0b013e328361e4bd
Laurent S, Boutouyrie P, Cunha P, Lacolley P, Nilsson P. Concept of Extremes in Vascular Aging From Early Vascular Aging to Supernormal Vascular Aging. Hypertension. 2019;74:218-228. https://doi.org/10.1161/HYPERTENSIONAHA.119.12655
Nilsson P. Early vascular ageing — a concept in development. Eur Endocrinology. 2015;11(1):26-31. https://doi.org/10.17925/EE.2015.11.01.26
Van de Laar RJ, Stehouwer CD, Prins MH, van Mechelen W, Twisk JW, Ferreira I. Self-reported time spent watching television is associated with arterial stiffness in young adults: the Amsterdam Growth and Health Longitudinal Study. Br J Sports Med. 2014;48(3):256-264. https://doi.org/10.1136/bjsports-2013-092555
Evsevyeva ME, Eremin MV, Koshel VI, Sergeeva OV, Rusidi AV, Fursova EN. The syndrome of early vascular aging in students and their risk factors. Clinical Cardiology. 2018;41(S1):12-13.
Philip R, Alpert BS, Schwingshackl A, Huang X, Blakely D, Rovnaghi CR, Tran QT, Velasquez A, Arevalo A, Anand KJ. Inverse Relationship between Cardio-Ankle Vascular Index and Body Mass Index in Healthy Children. The Journal of Pediatrics. 2015;167(2):361-365. https://doi.org/10.1016/j.jpeds.2015.04.042
Strelnikov AA, Obrezan AG, Shaidakov EV. Screening and prevention of topical diseases. A guide for physicians. SPb: Spetslit; 2012. (In Russ.).
Druzhilov MA, Kuznetsova TYu. Visceral obesity as risk factor of early vascular aging. Cardiology. 2016;2(56):52-56. (In Russ.). https://doi.org/10.18565/cardio.2016.2.52-56
Strazhesko ID, Tkacheva ON, Akasheva DU, Dudinskaya EN, Agaltsov MV, Kruglikova AS, Brailova NV, Pykhtina VS, Plokhova EV, Sharashkina NV, Isaikina OYu, Vygodin VA, Boytsov SA. Relationship between different structural and functional characteristics of the arterial wall state and traditional cardiovascular risk factors in healthy people of different ages. Part 2. Rational Pharmacotherapy in Cardiology. 2016;12(3):244-252. (In Russ.). https://doi.org/10.20996/1819-6446-2016-12-3-244-252
Corden B, Keenan NG, de Marvao AS, Dawes TJ, Decesare A, Diamond T, Durighel G, Hughes AD, Cook SA, O’Regan DP. Body fat is associated with reduced aortic stiffness until middle age. Hypertension. 2013;61:1322-1327. https://doi.org/10.1161/HYPERTENSIONAHA.113.01177
Dangardt F, Osika W, Volkmann R, Gan LM, Friberg P. Obese children show increased intimal wall thickness and decreased pulse wave velocity. Clin Physiol Funct Imaging. 2008;28:287-293. https://doi.org/10.1111/j.1475-097X.2008.00806.x
Lurbe E, Torro I, Garcia-Vicent C, Alvarez J, Fernandez-Fornoso JA, Redon J. Blood pressure and obesity exert independent influences on pulse wave velocity in youth. Hypertension. 2012;60:550-555. Hypertension. 2012;60(2): 550-555. https://doi.org/10.1161/HYPERTENSIONAHA.112.194746
Serés L, López-Ayerbe J, Coll R, Rodríguez O, Manresa JM, Marrugat J, Alastrue A, Formiguera X, Valle V. Cardiopulmonary function and exercise capacity in patients with morbid obesity. Rev Esp Cardiol. 2003;56(6): 594-600. https://doi.org/10.1016/s0300-8932(03)76921-8
Meerson FZ. Pathogenesis and prevention of stress and ischemic heart injuries. M.: Meditsina; 1984. (In Russ.).
Meerson FZ. Adaptation, stress and prevention. M.: Nauka; 1981. (In Russ.).
Charakida M, Jones A, Falaschetti E, Khan T, Finer N, Sattar N, Hingorani A, Lawlor DA, Smith GD, Deanfield JE. Childhood obesity and vascular phenotypes: a population study. J Am Coll Cardiol. 2012;60(25): 2643-2650. https://doi.org/10.1016/j.jacc.2012.08.1017
Evsevyeva ME, Koshel VI, Eremin MV, Galkova IYu, Rusidi AV, Chudnovsky EV, Korobova EYu, Frantseva VO. Screening of students’ health resources and the formation of an intra-University preventive environment: clinical, educational, and educational-pedagogical aspects. Medical Bulletin of the North Caucasus. 2015;10(1):64-69. (In Russ.). https://doi.org/10.14300/mnnc.2015.10009
Pälve KS, Pahkala K, Magnussen CG, Koivistoinen T, Juonala M, Kähönen M, Lehtimäki T, Rönnemaa T, Viikari JS, Raitakari OT. Association of physical activity in childhood and early adulthood with carotid artery elasticity 21 years later: the cardiovascular risk in Young Finns Study. J Am Heart Assoc. 2014;3(2):e000594. https://doi.org/10.1161/JAHA.113.000594
Ferreira I, Twisk JW, Van Mechelen W, Kemper HC, Stehouwer CD. Current and adolescent levels of cardiopulmonary fitness are related to large artery properties at age 36: the Amsterdam Growth and Health Longitudinal Study. Eur J ClinInvest. 2002;32:723-731. https://doi.org/10.1046/j.1365-2362.2002.01066.x