Scales for assessing the genetic risk of developing type 2 diabetes mellitus

Kurilova O.V.; Kiseleva A.V.; Meshkov A.N.; Sotnikova E.A.; Ershova A.I.; Ivanova A.A.; Limonova A.S.; Drapkina O.M.

doi:https://doi.org/10.17116/profmed202124121115

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Abstract:

Type 2 diabetes mellitus (T2DM) is an independent risk factor for cardiovascular diseases, the presence of which significantly increases cardiovascular risk. The main risk factors for the development of T2DM include obesity, unhealthy diet, reduced physical activity, and genetic predisposition. The heritability of type 2 diabetes, according to twin studies, reaches 72%. Currently, the most effective method for searching for genetic factors of complex diseases is a genome-wide search for associations, based on the results of which genetic risk scales can be created to identify individuals with a high risk of developing T2DM. The data obtained in the course of studies of the genetic factors of T2DM can be used for screening, prevention and development of new targeted pharmacotherapy with possible individually optimized treatment. The purpose of this review is to present relevant data on the contribution of heredity to the development of T2DM and to assess the genetic risk of its development.

Keywords:

GWAS

genetic risk scale

type 2 diabetes mellitus

Authors:

Kurilova O.V.

FSI «National Medical Research Center for Preventive Medicine» of the Ministry of Healthcare of the Russian Federation

Kiseleva A.V.

FSI «National Medical Research Center for Preventive Medicine» of the Ministry of Healthcare of the Russian Federation

Meshkov A.N.

National Medical Research Center for Therapy and Preventive Medicine

Sotnikova E.A.

FSI «National Medical Research Center for Preventive Medicine» of the Ministry of Healthcare of the Russian Federation

Ershova A.I.

National Medical Research Center for Therapy and Preventive Medicine

Ivanova A.A.

Federal Scientific Clinical Center for Children and Adolescents

ORCID: 0000-0003-1493-8481

Limonova A.S.

National Medical Research Center for Therapy and Preventive Medicine

Drapkina O.M.

National Medical Research Center for Therapy and Preventive Medicine;
A.I. Yevdokimov Moscow State University of Medicine and Dentistry

SPIN RSCI: 4456-1297
Scopus AuthorID: 57208852308
ResearcherID: G-8443-2016
ORCID: 0000-0002-4453-8430

Received:

08.11.2021

Accepted:

22.11.2021

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