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Menzhinskaya I.V.

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia

Adamyan L.V.

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia;
Russian University of Medicine, Moscow, Russia

Antonova A.A.

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia

Avetisyan D.S.

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia

Autoantibodies to vascular endothelial growth factor in women with premature ovarian insufficiency

Authors:

Menzhinskaya I.V., Adamyan L.V., Antonova A.A., Avetisyan D.S.

More about the authors

Journal: Russian Journal of Human Reproduction. 2026;32(3): 6‑14

DOI: 10.17116/repro2026320316

Read: 259 times

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Table of contents

AUTOANTIBODIES TO VASCULAR ENDOTHELIAL GROWTH FACTOR IN WOMEN WITH PREMATURE OVARIAN INSUFFICIENCY
AUTOANTIBODIES TO VASCULAR ENDOTHELIAL GROWTH FACTOR IN WOMEN WITH PREMATURE OVARIAN INSUFFICIENCY

To cite this article:

Menzhinskaya IV, Adamyan LV, Antonova AA, Avetisyan DS. Autoantibodies to vascular endothelial growth factor in women with premature ovarian insufficiency. Russian Journal of Human Reproduction. 2026;32(3):6‑14. (In Russ.)
https://doi.org/10.17116/repro2026320316

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Vascular endothelial growth factors (VEGF), particularly VEGF-A, play a key role in angiogenesis processes associated with folliculogenesis and embryo implantation. Impaired angiogenesis, as well as the autoimmune mechanism, are important components in the pathogenesis of premature ovarian insufficiency (POI), but their relationship remains unexplored.

OBJECTIVE

To evaluate the frequency and level of autoantibodies to VEGF-A in patients with POI compared to women with normal ovarian reserve.

MATERIAL AND METHODS

Using a modified enzyme-linked immunosorbent assay with recombinant human VEGF-A, serum autoantibodies (M, G) to VEGF-A were analyzed in women with POI (Group 1, n=52) and normal ovarian reserve (Group 2, n=30).

RESULTS

Groups 1 was characterized by diminished ovarian reserve, a high rate of primary infertility, endocrine and allergic diseases, ART programs, and surgical operations. Anti-VEGF-A antibodies were detected more frequently in Group 1 (36.5%) than in Group 2 (6.7%). The detection rate and level of IgG were higher in POI; the likelihood of their detection was 11.8 times higher than in the comparison group, and 8.3 times higher in patients with POI and autoimmune thyroiditis.

CONCLUSION

Autoantibodies to VEGF-A were detected in patients with POI, their prevalence and levels were higher than in women with normal ovarian reserve. Antibodies may be a risk factor for POI and have clinical, diagnostic and pathogenetic significance. Further study of autoantibodies to regulatory angiogenic molecules in obstetric and gynecological pathology is necessary.

Keywords:

premature ovarian insufficiency
diminished ovarian reserve
vascular endothelial growth factor
anti-VEGF-A autoantibodies

Authors:

Menzhinskaya I.V.

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia

Adamyan L.V.

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia;
Russian University of Medicine, Moscow, Russia

Antonova A.A.

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia

Avetisyan D.S.

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia

Received:

23.04.2026

Accepted:

10.05.2026

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