Endometriosis-associated pain and adhesions — new pathogenetic aspects and therapeutic approach

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Endometriosis is a genetic determined disease defined as the presence of endometrium-like tissue outside of the uterine cavity. Although the etiology of endometriosis remains elusive, immunological dysfunction and hormone imbalance are considered to cause an estrogen-dependent chronic inflammation leading to fibrosis and adhesion formation. Thus, endometriosis pathogenesis is not still fully elucidated, this article describes the role of immune system in endometriosis-associated pelvic pain and adhesions. At the same time, the impact of fibrosis on disease progression as well as on pain and infertility is considered. Furthermore, the efficacy of combined therapy with use of bovhyaluronidase azoximer is evaluated for treatment of pain and infertility, and prevention of endometriosis-related adhesions.

Keywords:

endometriosis

fibrosis

endometriosis-associated pain

adhesions

cytokine

bovhyaluronidase azoximer

Authors:

Yarmolinskaya M.I.

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology;
I.I. Mechnikov North-Western State Medical University

ORCID: 0000-0002-6551-4147

Adamyan L.V.

Moscow State Medical and Dental University named after A.I. Evdokimov

SPIN RSCI: 9836-2713
Scopus AuthorID: 7006372422
ResearcherID: Q-1722-2018
ORCID: 0000-0002-3253-4512

Received:

26.02.2023

Accepted:

01.03.2023

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