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Yarmolinskaya M.I.
D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology;
I.I. Mechnikov North-Western State Medical University
Adamyan L.V.
Moscow State Medical and Dental University named after A.I. Evdokimov
Endometriosis-associated pain and adhesions — new pathogenetic aspects and therapeutic approach
Journal: Russian Journal of Human Reproduction. 2023;29(2): 93‑100
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To cite this article:
Yarmolinskaya MI, Adamyan LV. Endometriosis-associated pain and adhesions — new pathogenetic aspects and therapeutic approach. Russian Journal of Human Reproduction.
2023;29(2):93‑100. (In Russ.)
https://doi.org/10.17116/repro20232902193
Endometriosis is a genetic determined disease defined as the presence of endometrium-like tissue outside of the uterine cavity. Although the etiology of endometriosis remains elusive, immunological dysfunction and hormone imbalance are considered to cause an estrogen-dependent chronic inflammation leading to fibrosis and adhesion formation. Thus, endometriosis pathogenesis is not still fully elucidated, this article describes the role of immune system in endometriosis-associated pelvic pain and adhesions. At the same time, the impact of fibrosis on disease progression as well as on pain and infertility is considered. Furthermore, the efficacy of combined therapy with use of bovhyaluronidase azoximer is evaluated for treatment of pain and infertility, and prevention of endometriosis-related adhesions.
Keywords:
Authors:
Yarmolinskaya M.I.
D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology;
I.I. Mechnikov North-Western State Medical University
Adamyan L.V.
Moscow State Medical and Dental University named after A.I. Evdokimov
Received:
26.02.2023
Accepted:
01.03.2023
List of references:
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