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Peshikov O.V.

South Ural State Medical University

Peshikova M.V.

South Ural State Medical University

The role of different microorganisms in the development of fallopian tube pathology (literature review)

Authors:

Peshikov O.V., Peshikova M.V.

More about the authors

Journal: Russian Journal of Human Reproduction. 2022;28(4): 39‑47

DOI: 10.17116/repro20222804139

Read: 1832 times

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Table of contents

THE ROLE OF DIFFERENT MICROORGANISMS IN THE DEVELOPMENT OF FALLOPIAN TUBE PATHOLOGY (LITERATURE REVIEW)
THE ROLE OF DIFFERENT MICROORGANISMS IN THE DEVELOPMENT OF FALLOPIAN TUBE PATHOLOGY (LITERATURE REVIEW)

To cite this article:

Peshikov OV, Peshikova MV. The role of different microorganisms in the development of fallopian tube pathology (literature review). Russian Journal of Human Reproduction. 2022;28(4):39‑47. (In Russ.)
https://doi.org/10.17116/repro20222804139

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The pathogenesis of the development of various infectious processes in the fallopian tubes has its own characteristics, taking into account both the characteristics of the pathogen and the morphological structure of the fallopian tubes. The impairment of the ciliary epithelium, changes in the muscle layer of the organ, the development of adhesions in the pelvic cavity can damage the reproductive function. The consequences of the inflammatory process in the fallopian tubes can cause the development of ectopic pregnancy, as well as tubo-peritoneal infertility. To date, a variety of mechanisms of direct and immune-mediated infectious damage of the fallopian tubes and developing complications have been described. The attention of researchers in publications of recent years is focused on the microbiome of fallopian tubes and relationship between their infectious pathology and the development of tumors of the female reproductive system. This article is devoted both to the study of the role of microorganisms in fallopian tube damage and to review of the mechanisms of their infectious and inflammatory impairment from modern positions.

Keywords:

fallopian tube
Chlamydia trachomatis
Neisseria gonorrhoeae
Herpes simplex virus
Cytomegalovirus
reproduction

Authors:

Peshikov O.V.

South Ural State Medical University

Peshikova M.V.

South Ural State Medical University

Received:

30.05.2021

Accepted:

06.06.2022

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References:

  1. Ashshi AM, Batwa SA, Kutbi SY, Malibary FA, Batwa M, Refaat B. Prevalence of 7 sexually transmitted organisms by multiplex real-time PCR in fallopian tube specimens collected from Saudi women with and without ectopic pregnancy. BMC Infectious Diseases. 2015;15:569.  https://doi.org/10.1186/s12879-015-1313-1
  2. Vander Borght M, Wyns C. Fertility and infertility: definition and epidemiology. Clinical Biochemistry. 2018;62:2-10.  https://doi.org/10.1016/j.clinbiochem.2018.03.012
  3. Lyons RA, Saridogan E, Djahanbakhch O. The reproductive significance of human fallopian tube cilia. Human Reproduction Update. 2006;12(4):363-372.  https://doi.org/10.1093/humupd/dml012
  4. Lenz JD, Dillard JP. Pathogenesis of Neisseria gonorrhoeae and the host defense in ascending infections of human fallopian tube. Frontiers of Immunology. 2018;9:2710. https://doi.org/10.3389/fimmu.2018.02710
  5. Konovalova MV, Korabelnikova IA, Vorobtsova IN, Shovina DE, Shvyndina AA, Sokolova ME, Konovalov LV. Peculiarities of changes of the morphological structure of the fallopian tubes against the background of chronic inflammation. Vestnik Novgorodskogo gosudarstvennogo universiteta. 2019;113(1):44-46. (In Russ.). https://doi.org/10.34680/2076-8052.2019.1(113).44-46
  6. Hou HY, Chen YQ, Chen X, Hu CX, Yang ZH, Chen J, Kong XL. Related factors associated with pelvic adhesion and its influence on fallopian tube recanalization in infertile patients. Zhonghua Fu Chan Ke Za Zhi. 2012;47(11):823-828. 
  7. Anikin SS, Livshits IV, Rybalka AN. Etiology and pathogenesis of ectopic pregnancy and its influence on reproductive health of women. Krymskij zhurnal eksperimental’noj i klinicheskoj meditsiny. 2012;7-8(3-4):4-9. (In Russ.)
  8. Nizyaeva NV, Marei MV, Sukhikh GT, Shchegolev AI. Interstitial pacemaker cells. Vestnik Rossiiskoj akademii meditsinskikh nauk. 2014;69(7-8):17-24. (In Russ.). https://doi.org/10.15690/vramn.v69i7-8.1105
  9. Popescu LM, Faussone-Pellegrini MS. Telocytes — a case of serendipity: the winding way from interstitial cells of Cajal (ICC), via interstitial Cajal-like cells (ICLC) to telocytes. Journal of Cellular and Molecular Medicine. 2010;14(4):729-740.  https://doi.org/10.1111/j.1582-4934.2010.01059.x
  10. Popescu LM, Ciontea SM, Cretoiu D, Hinescu ME, Radu E, Ionescu N, Ceausu M, Gherghiceanu M, Braga RI, Vasilescu F, Zagrean L, Ardeleanu C. Novel type of interstitial cell (Cajal-like) in human fallopian tube. Journal of Cellular and Molecular Medicine. 2005;9(2):479-523.  https://doi.org/10.1111/j.1582-4934.2005.tb00376.x
  11. Varga I, Urban L, Kajanová M, Polák Š. Functional histology and possible clinical significance of recently discovered telocytes inside the female reproductive system. Archives of Gynecology and Obstetrics. 2016;294(2):417-422.  https://doi.org/10.1007/s00404-016-4106-x
  12. Kuznetsov RE, Skripchenko DV, Paklina OV, Chekmareva IA. Ultrastructural changes in the uterine tubes telocytes during inflammation. Moskovskaya meditsina. 2019;34(6):59. (In Russ.).
  13. Yang XJ, Xu JY, Shen ZJ, Zhao J. Immunohistochemical alterations of Cajal-like type of tubal interstitial cells in women with endometriosis and tubal ectopic pregnancy. Archives of Gynecology and Obstetrics. 2013;288(6):1295-1300. https://doi.org/10.1007/s00404-013-2878-9
  14. Peshikov OV. On the structure of uterine tube. Morfologiya. 2019;155(1):73-77. (In Russ.).
  15. Kharchenko EI, Adamyan LV, Bragina EE, Murvatov KD, Zhordania KI. The evaluation of the distal portion of fallopian tubes in women of reproductive age who have benign tumors and tumor-like lesions of the ovary viewed from the perspective of electron microscopy. Onkoginekologiya. 2014;2:43-54. (In Russ.).
  16. Asaturova AV, Ezhova LS, Faizullina NM, Adamyan LV, Khabas GN. Tube-peritoneal junction: morphological and immunohistochemical features, the role in pelvic serous carcinoma pathogenesis. Klinicheskaya i eksperimental’naya morfologiya. 2016;17(1):11-17. (In Russ.).
  17. Zhordania KI. Serous ovarian carcinoma or serous carcinoma of uterine (fallopian) tube? Onkoginekologiya. 2012;3:4-9. (In Russ.).
  18. Kurman RJ, Shih le-M. The origin and pathogenesis of epithelial ovarian cancer: A proposed unifying theory. The American Journal of Surgical Pathology. 2010;34(3):433-443.  https://doi.org/10.1097/pas.0b013e3181cf3d79
  19. Pathak S, Wilczyński JR, Paradowska E. Factors in oncogenesis: viral infections in ovarian cancer. Cancers. 2020;12(3):E561. https://doi.org/10.3390/cancers12030561
  20. Stewart LM, Stewart CJR, Spilsbury K, Cohen PA, Jordan S. Association between pelvic inflammatory disease, infertility, ectopic pregnancy and the development of ovarian serous borderline tumor, mucinous borderline tumor and low-grade serous carcinoma. Gynecologic Oncology. 2020;156(3):611-615.  https://doi.org/10.1016/j.ygyno.2020.01.027
  21. Banerjee S, Tian T, Wei Z, Shih N, Feldman MD, Alwine JC, Coukos G, Robertson ES. The ovarian cancer oncobiome. Oncotarget. 2017;22(8):36225-36245. https://doi.org/10.18632/oncotarget.16717
  22. Askhakov MS, Chebotarev VV. The modern view on course, diagnosis and treatment of chlamydial infection. Vestnik molodogo uchenogo. 2018;22(3):26-32. (In Russ.).
  23. Witkin SS, Minis E, Athanasiou A, Leizer J, Linhares IM. Chlamydia trachomatis: the persistent pathogen. Clinical and Vaccine Immunology. 2017;24(10):00203-17.  https://doi.org/10.1128/CVI.00203-17
  24. Taylor-Robinson D, Jensen JS, Svenstrup H, Stacey CM. Difficulties experienced in defining the microbial cause of pelvic inflammatory disease. International Journal of STD & AIDS. 2012;23(1):18-24.  https://doi.org/10.1258/ijsa.2011.011066
  25. Cooper MD, Rapp J, Jeffery-Wiseman C, Barnes RC, Stephens DS. Chlamydia trachomatis infection of human fallopian tube organ cultures. Journal of General Microbiology. 1990;136(6):1109-1115. https://doi.org/10.1099/00221287-136-6-1109
  26. Jerchel S, Knebel G, König P, Bohlmann MK, Rupp J. A human fallopian tube model for investigation of C. trachomatis infections. Journal of Visualized Experiments. 2012;66:4036. https://doi.org/10.3791/4036
  27. Patton DL, Halbert SA, Kuo CC, Wang SP, Holmes KK. Host response to primary Chlamydia trachomatis infection of the fallopian tube in pig-tailed monkeys. Fertility and Sterility. 1983;40(6):829-840. 
  28. Hvid M, Baczynska A, Deleuran B, Fedder J, Knudsen HJ, Christiansen G, Birkelund S. Interleukin-1 is the initiator of fallopian tube destruction during Chlamydia trachomatis infection. Cellular Microbiology. 2007;12(9):2795-2803. https://doi.org/10.1111/j.1462-5822.2007.00996.x
  29. Ault KA, Tawfik OW, Smith-King MM, Gunter J, Terranova PF. Tumor necrosis factor-alpha response to infection with Chlamydia trachomatis in human fallopian tube organ culture. American Journal of Obstetrics and Gynecology. 1996;175(5):1242-1245. https://doi.org/10.1016/s0002-9378(96)70035-2
  30. Beatty WL, Byrne GI, Morrison RP. Morphologic and antigenic characterization of interferon gamma-mediated persistent Chlamydia trachomatis infection in vitro. Proceedings of the National Academy of Sciences of the United States of America. 1993;90(9):3998-4002. https://doi.org/10.1073/pnas.90.9.3998
  31. Karlin S, Brocchieri L. Heat shock protein 60 sequence comparisons: duplications, lateral transfer, and mitochondrial evolution. Proceedings of the National Academy of Sciences of the United States of America. 2000;97(21):11348-11353. https://doi.org/10.1073/pnas.97.21.11348
  32. Yi Y, Zhong G, Brunham RC. Continuous B-cell epitopes in Chlamydia trachomatis heat shock protein 60. Infection and Immunity. 1993;61(3):1117-1120. https://doi.org/10.1128/IAI.61.3.1117-1120.1993
  33. Witkin SS, Jeremias J, Toth M, Ledger WJ. Proliferative response to conserved epitopes of the Chlamydia trachomatis and human 60-kilodalton heat-shock proteins by lymphocytes from women with salpingitis. American Journal of Obstetrics and Gynecology. 1994;171(2):455-460.  https://doi.org/10.1016/0002-9378(94)90282-8
  34. Linhares IM, Witkin SS. Immunopathogenic consequences of Chlamydia trachomatis 60 kDa heat shock protein expression in the female reproductive tract. Cell Stress and Chaperones. 2010;15(5):467-473.  https://doi.org/10.1007/s12192-010-0171-4
  35. Hoenderboom BM, Van Benthem BHB, Van Bergen JEAM, Dukers-Muijrers NHTM, Getz HM, Hoebe CJPA, Hogewoning AA, Land JA, Van Der Sande MAB, Morre SA, Van Den Broek IVF. Relation between Chlamydia trachomatis infection and pelvic inflammatory disease, ectopic pregnancy and tubal factor infertility in a Dutch cohort of women previously tested for chlamydia in a chlamydia screening trial. Akusherstvo i ginekologiya. Novosti. Mneniya. Obuchenie. 2019;7(4(26):8-19. (In Russ.). https://doi.org/10.1136/sextrans-2018-053778
  36. Begum N, Anwary SA, Alfazzaman M, Mahzabin Z, Deeba F, Mostafa MA, Akhter M, Rahman MM. Correlation between seropositivity of Chlamydia trachomatis and tubal and/or pelvic pathology detected by diagnostic laparoscopy in subfertile women. Mymensingh Medical Journal: MMJ. 2017;26(4):840-845. 
  37. Vivoda M, Arsić B, Garalejić E, Cirković I, Djukić S. Examination of possible role of the chlamydial stress proteins in pathogenesis of ectopic pregnancy. Srpski Arhiv za Celokupno Lekarstvo. 2014;142(1-2):54-58.  https://doi.org/10.2298/sarh1402054v
  38. Ahmad SF, Brown JK, Campbell LL, Koscielniak M, Oliver C, Wheelhouse N, Entrican G, McFee S, Wills GS, McClure MO, Horner PJ, Gaikoumelou S, Lee KF, Critchley HOD, Duncan WC, Horne AW. Pelvic chlamydial infection predisposes to ectopic pregnancy by upregulating integrin β1 to promote embryo-tubal attachment. EBioMedicine. 2018;29:159-165.  https://doi.org/10.1016/j.ebiom.2018.02.020
  39. Dixon RE, Ramsey KH, Schripsema JH, Sanders KM, Ward SM. Time-dependent disruption of oviduct pacemaker cells by chlamydia infection in mice. Biology of Reproduction. 2010;83(2):244-253.  https://doi.org/10.1095/biolreprod.110.083808
  40. Jonsson S, Lundin E, Elgh F, Ottander U, Idahl A. Chlamydia trachomatis and anti-MUC1 serology and subsequent risk of high-grade serous ovarian cancer: A population-based case-control study in Northern Sweden. Translational Oncology. 2020;13(1):86-91.  https://doi.org/10.1016/j.tranon.2019.09.007
  41. Idahl A, Le Cornet C, González Maldonado S, Waterboer T, Bender N, Tjønneland A, Hansen L, Boutron-Ruault MC, Fournier A, Kvaskoff M, Boeing H, Trichopoulou A, Valanou E, Peppa E, Palli D, Agnoli C, Mattiello A, Tumino R, Sacerdote C, Onland-Moret NC, Gram IT, Weiderpass E, Quirós JR, Duell EJ, Sánchez MJ, Chirlaque MD, Barricarte A, Gil L, Brändstedt J, Riesbeck K, Lundin E, Khaw KT, Perez-Cornago A, Gunter MJ, Dossus L, Kaaks R, Fortner RT. Serologic markers of Chlamydia trachomatis and other sexually transmitted infections and subsequent ovarian cancer risk: results from the EPIC cohort. International Journal of Cancer. 2020;147(8):2042-2052. https://doi.org/10.1002/ijc.32999
  42. Laban M, Ibrahim EA, Hassanin AS, Nasreldin MA, Mansour A, Khalaf WM, Eldin AMB, Hussain SH, Elsafty MS, Hasanien AS. Chlamydia trachomatis infection in primary fallopian tube and high-grade serous ovarian cancers: A pilot study. International Journal of Women’s Health. 2019;11:199-205.  https://doi.org/10.2147/IJWH.S188938
  43. Askhakov MS, Chebotarev VV. The modern view on course, diagnosis and treatment of gonococcal infection. Vestnik molodogo uchenogo. 2017;17(3):50-55. (In Russ.).
  44. McGee ZA, Johnson AP, Taylor-Robinson D. Pathogenic mechanisms of Neisseria gonorrhoeae: observations on damage to human fallopian tubes in organ culture by gonococci of colony type 1 or type 4. The Journal of Infectious Diseases. 1981;143(3):413-422.  https://doi.org/10.1093/infdis/143.3.413
  45. Sinha RK, Rosenthal RS. Release of soluble peptidoglycan from growing gonococci: demonstration of anhydro-muramyl-containing fragments. Infection and Immunity. 1980;29(3):914-925.  https://doi.org/10.1128/iai.29.3.914-925.1980
  46. Mårdh PA, Baldetorp B, Håkansson CH, Fritz H, Weström L. Studies of ciliated epithelia of the human genital tract. 3: Mucociliary wave activity in organ cultures of human Fallopian tubes challenged with Neisseria gonorrhoeae and gonococcal endotoxin. British Journal of Venereal Diseases. 1979;55(4):256-264.  https://doi.org/10.1136/sti.55.4.256
  47. Cooper MD, McGraw PA, Melly MA. Localization of gonococcal lipopolysaccharide and its relationship to toxic damage in human fallopian tube mucosa. Infection and Immunity. 1986;51(2):425-430.  https://doi.org/10.1128/iai.51.2.425-430.1986
  48. Melly MA, McGee ZA, Rosenthal RS. Ability of monomeric peptidoglycan fragments from Neisseria gonorrhoeae to damage human fallopian-tube mucosa. The Journal of Infectious Diseases. 1984;149(3):378-386.  https://doi.org/10.1093/infdis/149.3.378
  49. Maisey K, Nardocci G, Imarai M, Cardenas H, Rios M, Croxatto HB, Heckels JE, Christodoulides M, Velasquez LA. Expression of proinflammatory cytokines and receptors by human fallopian tubes in organ culture following challenge with Neisseria gonorrhoeae. Infection and Immunity. 2003;71(1):527-532.  https://doi.org/10.1128/iai.71.1.527-532.2003
  50. McGee ZA, Clemens CM, Jensen RL, Klein JJ, Barley LR, Gorby GL. Local induction of tumor necrosis factor as a molecular mechanism of mucosal damage by gonococci. Microbial Pathogenesis. 1992;12(5):333-341.  https://doi.org/10.1016/0882-4010(92)90096-7
  51. Reyes PA, Vargas MF, García KP, Rubilar PS, Navarrete PA, Fuentes PM, Ríos MA, Orihuela PA, Vargas RH, Rubio VH, Heckels J, Christodoulides M, Cárdenas H, Velasquez LA. Apoptosis related genes expressed in cultured fallopian tube epithelial cells infected in vitro with Neisseria gonorrhoeae. Biological Research. 2007;40(3):319.  https://doi.org/10.4067/S0716-97602007000400006
  52. Rodríguez-Tirado C, Maisey K, Rodríguez FE, Reyes-Cerpa S, Reyes-López FE, Imarai M. Neisseria gonorrhoeae induced disruption of cell junction complexes in epithelial cells of the human genital tract. Microbes and Infection. 2012;14(3):290-300.  https://doi.org/10.1016/j.micinf.2011.11.002
  53. Juica NE, Rodas PI, Solar P, Borda P, Vargas R, Muñoz C, Paredes R, Christodoulides M, Velasquez LA. Neisseria gonorrhoeae challenge increases matrix metalloproteinase-8 expression in fallopian tube explants. Frontiers in Cellular and Infection Microbiology. 2017;7:399.  https://doi.org/10.3389/fcimb.2017.00399
  54. Edwards JL, Apicella MA. The molecular mechanisms used by Neisseria gonorrhoeae to initiate infection differ between men and women. Clinical Microbiology Reviews. 2004;17(4):965-981.  https://doi.org/10.1128/CMR.17.4.965-981.2004
  55. Lefrancq T, Orain I, Michalak S, Hourseau M, Fetissof F. Herpetic salpingitis and fallopian tube prolapse. Histopathology. 1999;34(6):548-550.  https://doi.org/10.1111/j.1365-2559.1999.00644.x
  56. Arestova IM, Kiseleva NI. Modern possibilities of combined chemotherapy and immune correction of urogenital herpes in obstetrics and gynecology. Meditsinskie novosti. 2013;9:21-27. (In Russ.).
  57. Clarke LM, Duerr A, Yeung KH, Brockman S, Barbosa C, Macasaet M. Recovery of cytomegalovirus and herpes simplex virus from upper and lower genital tract specimens obtained from women with pelvic inflammatory disease. The Journal of Infectious Diseases. 1997;176(1):286-288.  https://doi.org/10.1086/517268
  58. Paradowska E, Jabłońska A, Studzińska M, Wilczyński M, Wilczyński JR. Detection and genotyping of CMV and HPV in tumors and fallopian tubes from epithelial ovarian cancer patients. Scientific Reports. 2019;9(1):19935. https://doi.org/10.1038/s41598-019-56448-1
  59. Batwa SA, Ashshi AM, Kamfar FF, Ahmad J, Idris S, Khojah A, Al-Qadi NM, Refaat B. Prevalence of cytomegalovirus, and its effect on the expression of inducible and endothelial nitric oxide synthases in fallopian tubes collected from women with and without ectopic pregnancy. European Journal of Clinical Microbiology and Infectious Diseases. 2016;35(1):103-110.  https://doi.org/10.1007/s10096-015-2514-7
  60. Ashshi AM. Aberrant expression of interleukin-6 and its receptor in fallopian tubes bearing an ectopic pregnancy with and without tubal cytomegalovirus infection. Virusdisease. 2016;27(4):340-350.  https://doi.org/10.1007/s13337-016-0342-8
  61. Pelzer ES, Willner D, Buttini M, Hafner LM, Theodoropoulos C, Huygens F. The fallopian tube microbiome: implications for reproductive health. Oncotarget. 2018;9(30):21541-21551. https://doi.org/10.18632/oncotarget.25059
  62. Chen C, Song X, Wei W, Zhong H, Dai J, Lan Z, Li F, Yu X, Feng Q, Wang Z, Xie H, Chen X, Zeng C, Wen B, Zeng L, Du H, Tang H, Xu C, Xia Y, Xia H, Yang H, Wang J, Wang J, Madsen L, Brix S, Kristiansen K, Xu X, Li J, Wu R, Jia H. The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases. Nature Communications. 2017;8(1):875.  https://doi.org/10.1038/s41467-017-00901-0
  63. Khoury JE, Stikkelbroeck MM, Goodman A, Rubin RH, Cosimi AB, Fishman JA. Postmenopausal tubo-ovarian abscess due to Pseudomonas aeruginosa in a renal transplant patient: A case report and review of the literature. Transplantation. 2001;72(7):1241-1244. https://doi.org/10.1097/00007890-200110150-00010
  64. Goodwin K, Fleming N, Dumont T. Tubo-ovarian abscess in virginal adolescent females: A case report and review of the literature. Journal of Pediatric and Adolescent Gynecology. 2013;26(4):e99-102.  https://doi.org/10.1016/j.jpag.2013.02.004
  65. Cheong LHA, Emil SGS. Non-sexually transmitted tubo-ovarian abscess in an adolescent. Journal of Pediatric Surgery Case Reports. 2013;10(1):378-380.  https://doi.org/10.1016/j.epsc.2013.10.005
  66. Feuerstein JL, O’Gorman J, Jakus J. Sepsis secondary to Bacteroides fragilis tubo-ovarian abscess requiring hysterectomy and bilateral salpingo-oophorectomy. BMJ Case Reports. 2018;2018:bcr2017222460. https://doi.org/10.1136/bcr-2017-222460
  67. King JA, Olsen TG, Lim R, Nycum LR. Pseudomonas aeruginosa-infected IUD associated with pelvic inflammatory disease. A case report. The Journal of Reproductive Medicine. 2002;47(12):1035-1037.
  68. Meirow D, Moses A, Maayan S, Schenker JG. Chronic tuboovarian abscess due to Staphylococcus aureus: A case report and literature review. European Journal of Obstetrics and Gynecology and Reproductive Biology. 1989;33(3):275-279.  https://doi.org/10.1016/0028-2243(89)90142-1
  69. Chebotar IV. Mechanisms of antibiofilm immunity. Vestnik Rossijskoj akademii meditsinskikh nauk. 2012;67(12):22-29. (In Russ.).
  70. Shlepotina NM, Peshikova MV, Kolesnikov OL, Shishkova YuS. Modern conceptions about the mechanisms of interaction between biofilm and cellular immunity factors. Zhurnal mikrobiologii, epidemiologii i immunobiologii. 2020;97(1):83-90. (In Russ.). https://doi.org/10.36233/0372-9311-2020-97-1-83-90
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The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
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