Objective — to increase in efficiency and safety of treatment of a chronic nonspecific endometritis at patients with disorders of fertility. Material and methods. 115 patients with reproductive disturbances in the anamnesis (infertility, not incubation of pregnancy, failure of extracorporal fertilization and transfer of embryos) against the background of nonspecific inflammation of an endometrium are examined. Patients are randomly divided into 2 groups: into the 1st group 62 women to whom carried out the combined bacteriophage treatment — laser therapy, entered into the 2nd group — 53 patients receiving traditional treatment with inclusion of antibiotics of a broad spectrum of activity (doxycycline metronidazole in standard doses), immunomodulators, vitamin and mineral complexes, physical therapy. Patients of both groups are comparable according to kliniko-anamnestic data and initial parameters of inspection. Results. Patients of both groups had the leading microorganisms in an endometrium Staphylococcus spp. (23%), Escherichia coli (17%), Enterococcus (12%). With a smaller frequency Streptococcus spp., Klebsiella and others in the form of monocultures — met at 6.8% or associations from 2—3 microorganisms — in 93.2% of cases. Results of treatment estimated 2.5—3 months later after a course of treatment. When using a combination of bacteriophages and laser therapy in complex treatment of HE the expressed clinical regress of a disease happened in the form of reduction of pain and disappearances are more white in 92% of cases, in the form of normalization of menstrual function at 78.9% of women of the 1st group whereas at women of the 2nd group — in 62 and 67% of cases respectively. The full elimination of activators and endometrial managed to be reached at 93.4% of patients of the 1st group and at 72% of patients of the 2nd group. Conclusions. The technique of treatment of a chronic endometritis offered by us with use of a combination of bacteriophage treatment and laser therapy allows to ensure efficiency and safety of treatment due to suppression of growth of nonspecific microflora, improvement of microcirculation in bodies of a small pelvis, normalization of a trophicity of an internal cover of a uterus, optimization of an immune response, decrease in frequency of probable system side effects (from purpose of traditional therapy).