Treatment of iron deficiency anemia with Ferro-Folgamma in pregnant women

Fedorova T.A.; Borzykina O.M.; Dubrovina N.V.; Ivanets T.Iu.; Gurbanova S.R.

doi:https://doi.org/10.17116/repro2018242112-117

Fedorova T.A.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

Borzykina O.M.

Research Centre of obstetrics, gynecology & ,perinatology named after acad. V.I. Kulakov» Moscow, Russia, 117997

Dubrovina N.V.

Federal State Budgetary Iinstitution «National medical research center of obstetrics, gynecology and perinatology acad. V.I. Kulakov», Moscow, Russia

Ivanets T.Iu.

FGBU "Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova" Minzdravsotsrazvitiia Rossii, Moskva

Gurbanova S.R.

Federal State Budgetary Iinstitution «National medical research center of obstetrics, gynecology and perinatology acad. V.I. Kulakov», Moscow, Russia

Treatment of iron deficiency anemia with Ferro-Folgamma in pregnant women

Authors:

Fedorova T.A., Borzykina O.M., Dubrovina N.V., Ivanets T.Iu., Gurbanova S.R.

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Journal: Russian Journal of Human Reproduction. 2018;24(2): 112‑117

DOI: 10.17116/repro2018242112-117

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To cite this article:

Fedorova TA, Borzykina OM, Dubrovina NV, Ivanets TIu, Gurbanova SR. Treatment of iron deficiency anemia with Ferro-Folgamma in pregnant women. Russian Journal of Human Reproduction. 2018;24(2):112‑117. (In Russ.)
https://doi.org/10.17116/repro2018242112-117

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)

Использование инфографики авторами научных работ

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Abstract:

Objective — to evaluate the clinical efficiency and tolerability of iron-containing Ferro-Folgamma preparation in the treatment of iron deficiency anemia (IDA) in pregnant women. Material and methods. The study group comprised 37 pregnant women aged 21 to 42 years with IDA in gestational age of 16—30 weeks. All patients showed an easy or moderate degree of IDA. Treatment of IDA was carried out with Ferro-Folgamma preparation 1 capsule per day for seven weeks. Results. Dynamic analysis of hematological and ferrokinetic parameters revealed an increase in the level of hemoglobin from 103.7±4.1 to 116.8±5.3 g/l (p<0.05), serum iron from 8.41±4.3 to 15.93±4.8 μmol/l (p<0,05), ferritin — from 11.9±6.3 to 23.8±5.1 mg/l (p<0.05), as well as the level of hematocrit and the number of erythrocytes by the seventh week of treatment. Improvement of health was observed after two weeks of taking the Ferro-Folgamma. Levels of bilirubin, enzymes ALAT, ASAT, alkaline phosphatase in the blood showed no any side effects of Ferro-Folgamma. Allergic reactions were not found in any of the patients. Eight (21.6%) women noted adverse reactions: constipation, nausea, heartburn. Conclusion. High efficiency and good tolerability of the Ferro-Folgamma preparation in the treatment of mild and moderate iron-deficiency anemia in pregnant women is shown.

Keywords:

iron deficiency anemia

pregnancy

Ferro-Folgamma

efficiency and tolerability

Authors:

Fedorova T.A.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

Borzykina O.M.

Research Centre of obstetrics, gynecology & ,perinatology named after acad. V.I. Kulakov» Moscow, Russia, 117997

Dubrovina N.V.

Federal State Budgetary Iinstitution «National medical research center of obstetrics, gynecology and perinatology acad. V.I. Kulakov», Moscow, Russia

Ivanets T.Iu.

FGBU "Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova" Minzdravsotsrazvitiia Rossii, Moskva

Gurbanova S.R.

Federal State Budgetary Iinstitution «National medical research center of obstetrics, gynecology and perinatology acad. V.I. Kulakov», Moscow, Russia

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References:

World Health Organization. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. Vitamin and Mineral Nutrition Information System. WHO/NMH/NHD/MNM/11.1. Geneva: World Health Organization; 2011. http://www.who.int/vmnis/indicators/haemoglobin.pdf
Stevens G, Finucane M, De-Regil L, Paciorek CJ, Flaxman SR, Branca F, Peña-Rosas JP, Bhutta ZA, Ezzati M. Global, regional, and national trends in total and severe anaemia prevalence in children and pregnant and non-pregnant women for 1995—2011: a systematic analysis of population-representative data. Lancet Global Health. 2013;1(1):e16-e25. https://doi.org/10.1016/s2214-109x(13)70001-9
Cogswell ME, Parvanta I, Ickes L, Yip R, Brittenham GM. Iron supplementation during pregnancy, anemia, and birthweight: a randomised controlled trial. American Journal of Clinical Nutrition. 2003;78:773-781.
Arnold DL, Williams MA, Miller RS, Qiu C, Sorensen TK. Maternal iron deficiency anaemia is associated with an increased risk of abruption placentae — a retrospective case control study. Journal of Obstetrics and Gynaecology Research. 2009;35:446-452.
Pavlovich SV. Diagnostika i terapiya anemii u beremennykh i rodil’nits. M. 2015. (In Russ.)
Beard JL. Why iron deficiency is important in infant development. Journal of Nutrition. 2008;138:2534-2536.
Muñoz M, Acheson AG, Auerbach M, Besser M, Habler O, Kehlet H, Liumbruno GM, Lasocki S, Meybohm P, Rao Baikady R, Richards T, Shander A, So-Osman C, Spahn DR, Klein AA. International consensus statement on the peri-operative management of anaemia and iron deficiency. Anaesthesia. 2017; 72(2):233-247. https://doi.org/10.1111/anae.13773
Vertkin AL, Godulan OV, Gorodetskii VV, Skotnikov AS. Iron deficiency anemia and the choice of drug for its correction. Russkii meditsinskii zhurnal. 2010;5:260-265. (In Russ.)
Pavord S, Myers B, Robinson S, Allard S, Strong J, Oppenheimer C; British Committee for Standards in Haematology. UK guidelines on the management of iron deficiency in pregnancy. British Journal of Haematology. 2012;156(5):588-600.
McLean E, Cogswell M, Egli I, Wojdyla D, de Benoist B. Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System 1993—2005. Public Health Nutrition. 2009;12: 444-454.
Breymann C, Honegger C, Holzgreve W, Surbek D. Diagnosis and treatment of iron-deficiency anaemia during pregnancy and postpartum. Archives of Gynecology and Obstetrics. 2010;282(5):577-580. https://doi.org/10.1007/s00404-010-1532-z
Patient Blood Management, Blood Matters Program, Department of Health, Victoria, Australia. http://www.health.vic.gov.au/bloodmatters/tools/management.htm
Clevenger B, Mallett SV, Klein AA, Richards T. Patient blood management to reduce surgical risk. British Journal of Surgery. 2015;102:1325-1337. https://doi.org/10.1002/bjs.9898
Reveiz L, Gyte GML, Cuervo L.G, Casasbuenas A. Treatments for iron-deficiency anaemia in pregnancy (Review). Cochrane Database of Systematic Reviews.2011;10:CD003094. https://doi.org/10.1002/14651858
Konovodova EN, Serov VN, Burlev VA, Tyutyunnik VL, Kang NE, Protopopova TA, Sukhikh GT. Diagnosis, prevention and treatment of iron-deficiency states in pregnant and postpartum women. Clinical protocol. Akusherstvo i ginekologiya. 2012;4(2):3-9 (In Russ.)
Levinа AA, Kazyukova TV, Tsvetaeva NV, Sergeeva AI, Mamukova YuI, Romanova EA, Cybulskiaya MM. Hepcidin as a regulator of iron homeostasis. Pediatriya. 2008;87(1):67-74. (In Russ.)
Leong W, Lönnerdal B. Hepcidin the recently identified peptide that appears to regulate iron absorption. The Journal of Nutrition. 2004;134(1):1-4.
Bothwell TH. Iron requirements in pregnancy and strategies to meet them. The American Journal of Clinical Nutrition. 2000;72(1 suppl.):257S-264S.
Stuklov NI, Semenova EN. Iron deficiency anemia, modern diagnostic and treatment strategy, criteria for therapeutic efficacy. Klinicheskaya meditsina. 2013;12:61-67. (In Russ.)
Ghinea MM. Treatment of iron deficiency anemia with Ferro-Folgamma. Romanian Journal of Internal Medicine. 2004;42(1):225-230.
Sokur TN, Dubrovina NV. Iron-deficient status of pregnant women, their prevention and treatment. Meditsinskii sovet. 2014;9:64-67. (In Russ.)
Budanov PV, Musaev ZM. Problems of efficiency of correction of (latent) iron deficiency in pregnant women. Trudnyi patsient. 2011;9:8-9. (In Russ.)
Stuklov NI, Semenova EN. Treatment of iron deficiency anemia. What is more important, performance or portability? Is there an optimal solution? Zhurnal mezhdunarodnoi meditsiny. 2013;1(2):47-55. (In Russ.)
Konovodova EN, Dokueva RS-E, Yakunina NA. Iron deficiency in obstetrics and gynecology practice. Russkii meditsinskii zhurnal. 2011;20:1228-1231. (In Russ.)
Vyalov SS. Iron deficiency: clinical picture, diagnosis and treatment. Klinicheskaya farmakologiya i terapiya. 2015;24(4):74-80. (In Russ.)
Bobrov SA, Repinа MA, Klitsenko OA. Serum ferritin as a factor in predicting the development of iron deficiency anemia in pregnant women. Zhurnal akusherstva i zhenskikh boleznei. 2011;60(3):49-55 (In Russ.)