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Pshenichnyuk E.Yu.

V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow

Asaturova A.V.

V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia

Adamyan L.V.

Department of Reproductive Medicine and Surgery, Faculty of Postgraduate Professional Education, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia

Zaĭtsev N.V.

Orenburgskiĭ oblastnoĭ klinicheskiĭ onkologicheskiĭ dispanser

Predictive factors of ovarian endometrioma recurrence after laparoscopic excision: risk factors and prevention

Authors:

Pshenichnyuk E.Yu., Asaturova A.V., Adamyan L.V., Zaĭtsev N.V.

More about the authors

Journal: Russian Journal of Human Reproduction. 2018;24(2): 97‑107

DOI: 10.17116/repro201824297-107

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Table of contents

PREDICTIVE FACTORS OF OVARIAN ENDOMETRIOMA RECURRENCE AFTER LAPAROSCOPIC EXCISION: RISK FACTORS AND PREVENTION
PREDICTIVE FACTORS OF OVARIAN ENDOMETRIOMA RECURRENCE AFTER LAPAROSCOPIC EXCISION: RISK FACTORS AND PREVENTION

To cite this article:

Pshenichnyuk EYu, Asaturova AV, Adamyan LV, Zaĭtsev NV. Predictive factors of ovarian endometrioma recurrence after laparoscopic excision: risk factors and prevention. Russian Journal of Human Reproduction. 2018;24(2):97‑107. (In Russ.)
https://doi.org/10.17116/repro201824297-107

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Objective — examine the expression of proliferation and apoptosis factors (Ki-67, bcl-2), inflammation factors (NF-kβ p65, COX-2), adhesion factors (b-catenin), estrogen (ERα) and progesterone (PRα) receptors in ovarian endometrioma and determine predictive factors of recurrence of ovarian endometrioma from women of reproductive age during the follow-up period of 1.5 years after laparoscopic excision. Materials and methods. This study includes 109 patients of reproductive age with ovarian endometriosis. In this study histological and immunohistochemical methods are used. Immunohistochemical analysis of ovarian endometrioma was carried out using the Tissue-Tek Quick-Ray kit, which allows the preparation of paraffin blocks with a large number of tissue samples (tissue microarray). Specimens were prepared according to a standard protocol using the Immunostimulator Ventana Ultra. For the correct formulation of immunohistochemical reactions positive and negative controls were used. Statistical analysis was carried out using Statistica 10.0 and Microsoft Excel. Results. Diameter of ovarian endometrioma ≥4.5 cm, III—IV stage of the disease and presence of surgical interventions for endometriosis in the history are significant risk factors for recurrence of ovarian endometrioma during the follow-up period of 1.5 years after laparoscopic excision. According to immunohistochemical data, expression of PRα and β-catenin is significantly increased and expression of Ki-67, NF-kβ p65 and COX-2 is significantly lowered in ovarian endometrioma from patients with recurrent of ovarian endometrioma. Conclusion. Diameter of ovarian endometrioma, stage of the disease, presence of surgical interventions for endometriosis in the history, Ki-67, NF-kβ p65, СОХ-2, b-catenin and PRα may be potentially predictive factors for recurrence of ovarian endometrioma after laparoscopic excision. The immunohistochemical analysis of the Ki-67, NF-kβ p65, СОХ-2, β-catenin and PRα expression in ovarian endometrioma will allow to define patients with high risk of a recurrence of ovarian endometrioma and to individualize postoperative treatment of patients with ovarian endometrioma.

Keywords:

recurrence
predictive factors of recurrence
ovarian endometrioma
immunohistochemical analysis
Ki-67
bcl-2
NF-kβ p65
COX-2
β-catenin
ERα
PRα

Authors:

Pshenichnyuk E.Yu.

V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow

Asaturova A.V.

V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia

Adamyan L.V.

Department of Reproductive Medicine and Surgery, Faculty of Postgraduate Professional Education, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia

Zaĭtsev N.V.

Orenburgskiĭ oblastnoĭ klinicheskiĭ onkologicheskiĭ dispanser

Close metadata

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