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Adamyan L.V.

Department of Reproductive Medicine and Surgery, Faculty of Postgraduate Professional Education, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia

Aznaurova Ya.B.

Federal State University Scientific Center of obstetrics, gynecology and perynathology named after V.I. Kulakov, Ministry of Health of the Russian Federation, Moscow, Russia, 117997

Biomarkers of endometriosis — current trends

Authors:

Adamyan L.V., Aznaurova Ya.B.

More about the authors

Journal: Russian Journal of Human Reproduction. 2018;24(1): 57‑62

Read: 3859 times


To cite this article:

Adamyan LV, Aznaurova YaB. Biomarkers of endometriosis — current trends. Russian Journal of Human Reproduction. 2018;24(1):57‑62. (In Russ.)
https://doi.org/10.17116/repro201824157-62

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References:

  1. Vercellini P, Viganò P, Somigliana E, Fedele L. Endometriosis: pathogenesis and treatment. Nat Rev Endocrinol. 2013;10:5:261-275. https://doi.org/10.1038/nrendo.2013.255
  2. Leyendecker G, Wildt L, Mall G. The pathophysiology of endometriosis and adenomyosis: tissue injury and repair. Arch Gynecol Obstet. 2009;280:4:529-538. https://doi.org/10.1007/s00404-009-1191-0
  3. Burney RO, Giudice LC. Pathogenesis and pathophysiology of endometriosis. Fertil Steril. 2012;98:3:511-519. https://doi.org/10.1016/j.fertnstert.2012.06.029
  4. Rahmioglu N, et al. World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project: III. Fluid biospecimen collection, processing, and storage in endometriosis research. Fertil Steril. 2014;102:5:1233-1243. https://doi.org/10.1016/j.fertnstert.2014.07.1208
  5. Becker CM, et al. World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: I. Surgical phenotype data collection in endometriosis research. Fertil Steril. 2014;102:5:1213-1222. https://doi.org/10.1016/j.fertnstert.2014.07.709
  6. Sinaii N. High rates of autoimmune and endocrine disorders, fibromyalgia, chronic fatigue syndrome and atopic diseases among women with endometriosis: a survey analysis. Hum Reprod. 2002;17:10:2715-2724. https://doi.org/10.1093/humrep/17.10.2715
  7. Parazzini F, Esposito G, Tozzi L, Noli S, Bianchi S. Epidemiology of endometriosis and its comorbidities. Eur J Obstet Gynecol Reprod Biol. 2017;209:3-7. https://doi.org/10.1016/j.ejogrb.2016.04.021
  8. Tietjen GE, Bushnell CD, Herial NA, Utley C, White L, Hafeez F. Endometriosis is associated with prevalence of comorbid conditions in migraine: CME. Headache. 2007;47:7:1069-1078. https://doi.org/10.1111/j.1526-4610.2007.00784.x
  9. May KE, Conduit-Hulbert SA, Villar J, Kirtley S, Kennedy SH, Becker CM. Peripheral biomarkers of endometriosis: a systematic review. Hum Reprod Update. 2010;16: 6:651-674. https://doi.org/10.1093/humupd/dmq009
  10. May KE, Villar J, Kirtley S, Kennedy SH, Becker CM. Endometrial alterations in endometriosis: A systematic review of putative biomarkers. Hum Reprod Update. 2011;17:5:637-653. https://doi.org/10.1093/humupd/dmr013
  11. Nisenblat V, Prentice L, Pmm B, Farquhar C, Johnson N. Combination of the non-invasive tests for the diagnosis of endometriosis (review). 2016;7. https://doi.org/10.1002/14651858.cd012281
  12. Vicente-Muñoz S, Morcillo I, Puchades-Carrasco L, Payá V, Pellicer A, Pineda-Lucena A. Pathophysiologic processes have an impact on the plasma metabolomic signature of endometriosis patients. Fertil Steril. 2016;106:7:1733-1741.e1. https://doi.org/10.1016/j.fertnstert.2016.09.014
  13. Vicente-Muñoz S, Morcillo I, Puchades-Carrasco L, Payá V, Pellicer A, Pineda-Lucena A. Nuclear magnetic resonance metabolomic profiling of urine provides a noninvasive alternative to the identification of biomarkers associated with endometriosis. Fertil Steril. 2015;104:5:1202-1209 https://doi.org/10.1016/j.fertnstert.2015.07.1149
  14. Kocbek V, Vouk K, Mueller MD, Rižner TL, Bersinger N. Elevated glycodelin-A concentrations in serum and peritoneal fluid of women with ovarian endometriosis. Gynecol Endocrinol. 2013;29:5:455-459. https://doi.org/10.3109/09513590.2013.769516
  15. Vodolazkaia A, et al. Evaluation of a panel of 28 biomarkers for the non-invasive diagnosis of endometriosis. Hum Reprod. 2012;27:9:2698-2711. https://doi.org/10.1093/humrep/des234
  16. Paiva P, Lappas M, Barker G. Using symptom scores, lifestyle measures and biochemical markers to create a test for endometriosis. J Endometr. 2014;6:3:135-143. https://doi.org/10.5301/je.5000194
  17. Philippoussis F, Gagne D, Hugo P. Concentrations of alpha-fetoprotein, insulin-like growth factor binding protein-3, c-erbB-2, and epidermal growth factor in serum of patients with endometriosis. J Soc Gynecol Investig. 2004;11:3:175-181. https://doi.org/10.1016/j.jsgi.2003.10.005
  18. Khan KN, Masuzaki H, Fujishita A, Kitajima M, Miura S. Peritoneal fluid and serum levels of hepatocyte growth factor may predict the activity of endometriosis. Acta Obstet Gynecol Scand. 2006;85:4:458-466. https://doi.org/10.1080/00016340500432556
  19. Kalu E, et al. Cytokine profiles in serum and peritoneal fluid from infertile women with and without endometriosis. J Obstet Gynaecol Res. 2007;33:4:490-495. https://doi.org/10.1111/j.1447-0756.2007.00569.x
  20. Steff AM, Gagne D, Page M, Rioux A, Hugo P, Hugo D. Serum concentrations of insulin-like growth factor-1, soluble tumor necrosis factor receptor-1 and angiogenin in endometriosis patients. Am J Reprod Immunol. 2004;51:2:166-173. https://doi.org/10.1046/j.8755-8920.2003.00138.x
  21. Da Silva CM, Vilaca Belo A, Passos Andrade S, L. da S.-Campos P, Cristina Franca Ferreira M, Filho A. Identification of local angiogenic and inflammatory markers in the menstrual blood of women with endometriosis. Biomed Pharmacother. 2014;68:7:899-904. https://doi.org/10.1016/j.biopha.2014.08.005
  22. Wessels VR, Kay NA, Leyland SK, Agarwal W, Foster G. Assessing brain-derived neurotrophic factor as a novel clinical marker of endometriosis. Fertil Steril. 2016;105:1:119-128e5. https://doi.org/10.1016/j.fertnstert.2015.09.003
  23. Lima AP, Rosa E, Silva AAM. FSH, LH, estradiol, progesterone, and histamine concentrations in serum, peritoneal fluid and follicular fluid of women with and without endometriosis [Concentrações de FSH, LH, estradiol, progesterona e histamina no soro, no fluido peritoneal e no fluido. Rev Bras Ginecol e Obstet. 2006;28:11:643-651. https://doi.org/10.1590/S0100-72032006001100003
  24. Hapangama DK, TurnerMA, Drury JA, Quenby S, Martin-Ruiz C, Endometriosis is associated with aberrant endometrial expression of telomerase and increased telomere length. Hum Reprod. 2008;23:7:1511-1519. https://doi.org/10.1093/humrep/den172
  25. Szubert M, Suzin J, Duechler M, Szuawska A, et al. Evaluation of selected angiogenic and inflammatory markers in endometriosis before and after danazol treatment. Reprod Fertil Dev. 2014;26:3:414-420. https://doi.org/10.1071/rd12258
  26. Drosdzol-Cop A, Skrzypulec-Plinta V. Serum and peritoneal fluid immunological markers in adolescent girls with chronic pelvic pain. Obstet Gynecol Surv. 2012;67:6:374-381. https://doi.org/10.1097/ogx.0b013e31825cb12b
  27. Andreoli CG, Genro VK, Souza CA, Michelon T, Scheffel C. T helper (Th)1, Th2, and Th17 interleukin pathways in infertile patients with minimal/mild endometriosis. Fertil Steril. 2011;95:8:2477-2480. https://doi.org/10.1016/j.fertnstert.2011.02.019
  28. Suen JL, Chang Y, Chiu PR, Hsieh TH, Hsi E, et al. Serum level of IL-10 is increased in patients with endometriosis, and IL-10 promotes the growth of lesions in a murine model. Am J Pathol. 2014;184:2:464-471. https://doi.org/10.1016/j.ajpath.2013.10.023
  29. Othman E, Homung D, Salem HT, Khalifa EA, Metwally TH. Serum cytokines as biomarkers for nonsurgical prediction of endometriosis. Eur J Obstet Gynecol Reprod Biol. 2008;137:2:240-246. https://doi.org/10.1016/j.ejogrb.2007.05.001
  30. Lin J, Zhang XM, Deng L, Chen ZY. Determination of interleukine-16 levels in peritoneal fluid and serum of women with endometriosis. Zhejiang Daxue Xuebao [Journal Zhejiang Univ. (Medical Sci.). 2005;34:3:260-262.
  31. Fairbanks F, Abrao MS, Podgaec S, Dias JAJr, de Oliveira RM. Interleukin-12 but not interleukin-18 is associated with severe endometriosis. Fertil Steril. 2009;91:2:320-324. https://doi.org/10.1016/j.fertnstert.2007.11.060
  32. Wang WT, Zhao YN, Han BW, Hong SJ, Chen YQ, Wang X. Circulating microRNAs identified in a genomewide serum microRNA expression analysis as noninvasive biomarkers for endometriosis [Study on polymorphism of human leukocyte antigen I in patients with endometriosis. J Clin Endocrinol Metab. 2013;98:1:281-289. https://doi.org/10.1210/jc.2012-2415
  33. Jia SZ, Yang Y, Lang J, Sun P. Plasma miR-17-5p, miR-20a and miR-22 are down-regulated in women with endometriosis. Hum Reprod. 2013;28:2:322-330. https://doi.org/10.1093/humrep/des413
  34. Chen Y., et al. Evaluation of circulating endometrial cells as a biomarker for endometriosis. Chin Med J (Engl). 2017;130:19:2339-2345. https://doi.org/10.4103/0366-6999.215325
  35. Foda AA. Role of some biomarkers in chronic pelvic pain for early detection of endometriosis in infertile women. Middle East Fertil Soc J. 2012;17:3:187-194. https://doi.org/10.1016/j.mefs.2012.06.002
  36. Agic A, Djalali S, Wolfler MM, Halis G. Combination of CCR1 mRNA, MCP1, and CA125 measurements in peripheral blood as a diagnostic test for endometriosis. Reprod Sci. 2008;15:9:906-911. https://doi.org/10.1177/1933719108318598
  37. Adamyan LV, Farkhat KN, Makiyan ZN, Savilova AM. The external genital endometriosis: theories and molecular investigations (a review). Problemy reproduktsii. 2015;21:5:8-16. (In Russ.) https://doi.org/10.17116/repro20152158-16
  38. Zairatyants OV, Adamyan LV, Sonova MM, Borzenkova IP, Opalenov КV, Barsanova TG, Movtayeva KhR. Cytochrome P-450 aromatase expression in the ectopic and eutopic endometrium in endometriosis. Arkhiv patologii. 2008;70:5:16-20. (In Russ.)
  39. Ozhan E, Kokcu A, Yanik K, Gunaydin M. Investigation of diagnostic potentials of nine different biomarkers in endometriosis. Eur J Obstet Gynecol Reprod Biol. 2014;178:128-133. https://doi.org/10.1016/j.ejogrb.2014.04.037
  40. Hatok J, Zubor P, Galo S, Kirschnerova R, Danko J. Endometrial aromatase mRNA as a possible screening tool for advanced endometriosis and adenomyosis. Gynecol Endocrinol. 2011;27:5: 331-336. https://doi.org/10.3109/09513590.2010.491925
  41. Hudelist G, Czerwenka K, Keckstein J, Haas C, Retter A, Gschwantler-Kaulich D. Expression of aromatase and estrogen sulfotransferase in eutopic and ectopic endometrium: evidence for unbalanced estradiol production in endometriosis. Reprod Sci. 2007;14:8:798-805. https://doi.org/10.1177/1933719107309120
  42. Visnovsky J, Galo S, Zubor P, Hatok J, et al. Semiquantitative analysis of mRNA aromatase expression in eutopic endometrium as a diagnostic marker of endometriosis and estrogen dependent diseases. Ces Gynecol. 2008;73:4:213-217.
  43. Matsuzaki S, Canis M, Pouly JL, Dechelotte PJ. Analysis of aromatase and 17beta-hydroxysteroid dehydrogenase type 2 messenger ribonucleic acid expression in deep endometriosis and eutopic endometrium using laser capture microdissection. Fertil Steril. 2006;85:2:308-313. https://doi.org/10.1016/j.fertnstert.2005.08.017
  44. Meola J, Hidalgo Gdos S, Silva JC, Silva LE, RA F. Caldesmon: new insights for diagnosing endometriosis. Bioloy Reprod. 2013;88:5:122. https://doi.org/10.1095/biolreprod.112.103598
  45. Gilabert-Estelles J, Ramon LA, Espana F, Gilabert J, Reganon E, Castello R, Chirivella M. Expression of angiogenic factors in endometriosis: relationship to fibrinolytic and metalloproteinase systems. Hum Reprod. 2007;22:8:2120-2127. https://doi.org/10.1093/humrep/dem149
  46. Laudanski P, Charkiewicz R, Kuzmicki M, Swiatecka J, Mroczko B. Profiling of selected angiogenesis-related genes in proliferative eutopic endometrium of women with endometriosis. Eur J Obstet Gynecol Reprod Biol. 2014;172:1:85-92. https://doi.org/10.1016/j.ejogrb.2013.10.007
  47. Da Silva CM, Belo AV, Andrade SP, Campos PP, Ferreira MCF, Da Silva-Filho AL. Identification of local angiogenic and inflammatory markers in the menstrual blood of women with endometriosis. Biomed Pharmcotherapy. 2014;68:7:899-904. https://doi.org/10.1016/j.biopha.2014.08.005
  48. Ramon LA, Braza-Boils A, Gilabert-Estelles J, Espana F, Chirivella M. microRNAs expression in endometriosis and their relation to angiogenic factors. Hum Reprod. 2011;26:5:1082-1090. https://doi.org/10.1097/ogx.0b013e31824021f9
  49. Борисова А.В., Козаченко А.В., Стародубцева Н.Л., Коган Е.А., Чаговец В.В., Салимова Д.Ф., Кононихин А.С., Адамян Л.В. Сравнительный анализ молекулярного состава эктопического и эутопического эндометрия методами масс-спектрометрии и иммуногистохимии у пациентов с наружным генитальным эндометриозом. Проблемы репродукции. 2017;1:54-60. [Borisova АV, Kozachenko AV, Starodubtseva NL, Kogan ЕА, Chagovets VV, Salimova DF, Kononikhin АS, Adamyan LV. Comparative analysis of the molecular composition of ectopic and eutopic endometrium evaluated by mass spectrometry and immunohistochemistry in endometriosis. Problemy reproduktsii. 2017;1:54-60. (In Russ.]. https://doi.org/10.17116/repro201723154-60
  50. Takahashi K, Nagata H, Abu-Masa A, Yamasaki H. Clinical usefulness of Ca125 levels in the menstrual discharge in patients with endometriosis. Fertil Steril. 1990;54:2:360-362. https://doi.org/10.1016/s0015-0282(16)53721-2
  51. Tamaresis JS, Irwin JC, Goldfien GA, Rabban JT, Nezhat C. Molecular classification of endometriosis and disease stage using high-dimensional genomic data. Endocrinology. 2014;155:4386-4399. https://doi.org/10.1210/en.2014-1490
  52. Kuznetsova MV, Pshenichnyuk EYu, Burmenskaya OV, Asaturova AV, Trofimov DYu, Adamyan LV. Study of gene expressions in the eutopic endometrium of women with endometrioid ovarian cysts. Problemy reproduktsii. 2017;8:93-102. (In Russ.) https://doi.org/10.18565/aig.2017.8.93-102
  53. Herndon CN, Aghajanova L, Vo KC, Giudice LC. Global Transcriptome Abnormalities of the Eutopic Endometrium From Women With Adenomyosis. Reprod Sci. 2016;23:10:1289-1303. https://doi.org/10.1016/j.fertnstert.2010.07.838
  54. Adamyan LV, Spitsyn VA, Andreeva EN. Geneticheskie aspekty ginekologicheskikh zabolevanii. M.: GEOTAR-Media; 2008. (In Russ.)
  55. Yun BH, Lee YS, Chon SJ, Jung YS, Yim SY, Kim HY et al. Evaluation of elevated urinary enolase I levels in patients with endometriosis. Biomarkers. 2014;19:1:16-21. https://doi.org/10.3109/1354750x.2013.863973
  56. Cho S, Choi YS, Yim SY, Yang HI, Jeon YE, Lee KE. Urinary vitamin D-binding protein is elevated in patients with endometriosis. Hum Reprod. 2012;27:2:515-522, https://doi.org/10.1093/humrep/der345
  57. Cho SH, Oh YJ, Nam A, Kim HY, Park JH, Kim JH, et al. Evaluation of serum and urinary angiogenic factors in patients with endometriosis. Am J Reprod Immunol. 2007;58:6:497-504. https://doi.org/10.1111/j.1600-0897.2007.00535.x
  58. Potlog-Nahari C, Stratton P, Winkel C, Widra Z, Connors S. Urine vascular endothelial growth factor-A is not a useful marker for endometriosis. Fertil Steril. 2004;81:6:1507-1512. https://doi.org/10.1016/j.fertnstert.2003.10.040
  59. Grande G, Vincenzoni F, Milardi D, Pompa D, Ricciardi D, Fruscella E, Mancini F, Pontecorvi A, Castagnola M, Marana R. Cervical mucus proteome in endometriosis. Clin Proteomics. 2017;14:1:7. https://doi.org/10.1186/s12014-017-9142-4

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