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Zil'berman L.I.

FGBU "Éndokrinologicheskiĭ nauchnyĭ tsentr" Minzdrava RF

Kuraeva T.L.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr Minzdravsotsrazvitiia Rossiĭskoĭ Federatsii, Moskva

Peterkova V.A.

Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Federal clinical recommendations on diagnostics and treatment of type 2 diabetes mellitus in the children and adolescents

Authors:

Zil'berman L.I., Kuraeva T.L., Peterkova V.A.

More about the authors

Journal: Problems of Endocrinology. 2014;60(5): 57‑68

DOI: 10.14341/probl201460557-68

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Table of contents

FEDERAL CLINICAL RECOMMENDATIONS ON DIAGNOSTICS AND TREATMENT OF TYPE 2 DIABETES MELLITUS IN THE CHILDREN AND ADOLESCENTS
FEDERAL CLINICAL RECOMMENDATIONS ON DIAGNOSTICS AND TREATMENT OF TYPE 2 DIABETES MELLITUS IN THE CHILDREN AND ADOLESCENTS

To cite this article:

Zil'berman LI, Kuraeva TL, Peterkova VA. Federal clinical recommendations on diagnostics and treatment of type 2 diabetes mellitus in the children and adolescents. Problems of Endocrinology. 2014;60(5):57‑68. (In Russ.)
https://doi.org/10.14341/probl201460557-68

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Abstract:

Type 2 diabetes mellitus (DM2) morbidity has increased over the past years. Its rapid growth affects young subjects among those of other age groups including adolescents and pre-pubertal children. The diseases develops in the association with obesity and metabolic syndrome but remains asymptomatic during a long period. Therefore, its detection requires an active diagnostic search. The present clinical recommendations highlight the major problems pertaining to the diagnostic and treatment strategies for the management of the patients presenting with type 2 diabetes mellitus.

Keywords:

type 2 diabetes mellitus
children and adolescents
hyperinsulinemia
insulin resistance
biguanides.

Authors:

Zil'berman L.I.

FGBU "Éndokrinologicheskiĭ nauchnyĭ tsentr" Minzdrava RF

Kuraeva T.L.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr Minzdravsotsrazvitiia Rossiĭskoĭ Federatsii, Moskva

Peterkova V.A.

Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

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References:

  1. Dedov I.I., Kuraeva T.L., Peterkova V.A. Sakharnyĭ diabet u deteĭ i podrostkov. M: GéOTAR-Media 2007.
  2. Dedov I.I., Remizov O.V., Peterkova V.A. Geneticheskaia geterogennost' i kliniko-metabolicheskie aspekty sakharnogo diabeta s autosomno-dominantnym nasledovaniem (tip MODY) u deteĭ i podrostkov. Pediatriia 2000; 6: 77-83.
  3. Dedov I.I., Remizov O.V., Peterkova V.A. Sakharnyĭ diabet 2-go tipa u deteĭ i podrostkov. Sakharnyĭ diabet 2001; 4: 26-32.
  4. Eremina I.A., Zil'berman L.I., Dubinina I.A. i dr. Osobennosti sakharnogo diabeta 2-go tipa bez ozhireniia u deteĭ i podrostkov. Vserossiĭskiĭ diabetologicheskiĭ kongress, 6-ĭ: Materialy. M 2013; 299.
  5. Eremina I.A., Kuraeva T.L. Metformin v lechenii sakharnogo diabeta 2-go tipa u deteĭ i podrostkov. Probl éndokrinol 2013; 59: 1: 8-13.
  6. Adelman R.D., Restaino I.G., Alon U.S. et al. Proteinuria and focal segmental glomerulosclerosis in severely obese adolescents. J Pediatr 2001; 138: 4: 481-485. doi:10.1067/mpd.2001.113006.
  7. American Diabetes Association. Type 2 diabetes in children and adolescents. Am Diabet Ass Diabet Care 2000; 23: 3: 381-389. doi: 10.2337/diacare.23.3.381.
  8. Banerjee S., Raghavan S., Wasserman E.J., Linder B.L., Saenger P., DiMartino-Nardi J. Hormonal findings in African American and Caribbean Hispanic girls with premature adrenarche: implications for polycystic ovarian syndrome. Pediatrics 1998; 102: 3: E35. Doi: 10.1542/peds.102.2e36.
  9. Banerji M.A. Diabetes in African Americans: unique pathophysiologic features. Curr Diabet Rep 2004; 4: 3: 219-223.
  10. Berenson G.S., Srnivasan S.R. Cardiovascular risk factors in youth with implications for aging: the Bogalusa Heart Study. Neurobiol Aging 2005; 26: 3: 303-307. Doi: 10.1016/j.neurobiolaging.2004.05.009.
  11. Braun B., Zimmermann M.B., Kretchmer N., Spargo R.M., Smith R.M., Gracey M. Risk factors for diabetes and cardiovascular disease in young Australian aborigines: a 5-year follow-up study. Diabet Care 1996; 19: 5: 472-479.
  12. Chan J.C., Cheung C.K., Swaminathan R., Nicholls M.G., Cockram C.S. Obesity albuminuria, and hypertension among Hong Kong Chinese with noninsulin dependent diabetes mellitus (NIDDM). Postgrad Med J 1993; 69: 809: 204-210. doi: 10.1136/pgmj.69.809.204.
  13. Dahlquist G., Blom L., Tuvemo T., Nyström L., Sandström A., Wall S. The Swedish childhood diabetes study--results from a nine year case register and a one year case-referent study indicating that type 1 (insulin-dependent) diabetes mellitus is associated with both type 2 (non-insulin-dependent) diabetes mellitus and autoimmune disorders. Diabetologia 1989; 32: 1: 2-6.
  14. Dietz W.H., Gross W.L., Kirkpatrick J.A. Blount disease (tibia vara): another skeletal disorder associated with childhood obesity. Pediatr 1982; 101: 5: 735-737.
  15. Drake A.J., Smith A., Betts P.R., Crowne E.C., Shield J.P. Type 2 diabetes in obese white children. Arch Dis Child 2002; 86: 3: 207-208. doi:10.1136/adc.86.3.207.
  16. Druet C., Tubiana-Rufi N., Chevenne D., Rigal O., Polak M., Levy-Marchal C. Characterization of insulin secretion and resistance in type 2 diabetes of adolescents. J Clin Endocrinol Metabol 2006; 91: 2: 401-404. Doi: 10.1210/jc.2005-1672.
  17. Duncan G.E. Prevalence of diabetes and impaired fasting glucose levels among US adolescents: National Health and Nutrition Examination Survey, 1999-2002. Arch Pediatr Adolesc Med 2006; 160: 5: 523-528. doi:10.1001/archpedi.160.5.523.
  18. Ehtisham S., Hattersley A.T., Dunger D.B., Barrett T.G. British Society for Paediatric Endocrinology and Diabetes Clinical Trials Group. First UK survey of paediatric type 2 diabetes and MODY. Arch Dis Child 2004; 89: 6: 526-529. doi:10.1136/adc.2003.027821.
  19. Eppens M.C., Craig M.E., Jones T.W., Silink M., Ong S., Ping Y.J. International Diabetes Federation Western Pacific Region Steering Committee. Type 2 diabetes in youth from the Western Pacific region: glycemic control, diabetes care and complications. Curr Med Res Opinion 2006; 22: 5: 1013-1020.
  20. Freedman D.S., Khan L.K., Dietz W.H., Srinivasan S.R., Berenson G.S. Relationship of childhood obesity to coronary heart disease risk factors in adulthood: the Bogalusa heart study. Pediatrics 2001; 108: 3: 712-718. doi: 10.1542/peds.108.3.712.
  21. Goldberg I.J. Diabetic dyslipidemia: causes and consequences. J Clin Endocrinol Metabol 2001; 86: 3: 965-971.
  22. Goran M.I., Bergman R.N., Avila Q., Watkins M., Ball G.D., Shaibi G.Q., Weigensberg M.J., Cruz M.L. Impaired glucose tolerance and reduced cell function in overweight Latino children with a positive family history for type 2 diabetes. J Clin Endocrinol Metabol 2004; 89: 1: 207-212. Doi: 10.1210/jc.2003-031402.
  23. Gottlieb M.S. Diabetes in offspring and siblings of juvenile- and maturity-onset type diabetics. J Chronic Dis 1980; 33: 6: 331-339.
  24. Gress T.W., Nieto F.J., Shahar E., Wofford M.R., Brancati F.L. Hypertension and antihypertensive therapy as risk factors for type 2 diabetes mellitus. Atherosclerosis Risk in Community Study. N Engl J Med 2000; 342: 13: 905-912. Doi: 10.1056/NEJM200003303421301.
  25. Hathout E.H., Thomas W., El-Shahawy M., Nahab F., Mace J.W. Diabetic autoimmune markers in children and adolescents with type 2 diabetes. Pediatrics 2001; 107: 6: E102. doi: 10.1542/peds.107.6.e102.
  26. Ibáñez L., Potau N., Marcos M.V., de Zegher F. Exaggerated adrenarche and hyperinsulinism in adolescent girls born small for gestational age. J Clin Endocrinol Metabol 1999; 84: 12: 4739-4741. Doi: 10.1210/jcem.84.12.6341.
  27. Invitti C., Guzzaloni G., Gilardini L., Morabito F., Viberti G. Prevalence and concomitants of glucose intolerance in European obese children and adolescents. Diabet Care 2003; 26: 1: 118-124. doi: 10.2337/diacare.26.1.118.
  28. Juonala M., Järvisalo M.J., Mäki-Torkko N., Kähönen M., Viikari J.S., Raitakari O.T. Risk factors identified in childhood and decreased carotid artery elasticity in adulthood: the Cardiovascular Risk in Young Finns Study. Circulation 2005; 112: 10: 1486-1493. doi: 10.1161/CIRCULATIONAHA.104.502161.
  29. Kadiki O., Reddy M., Marzouk A. Incidence of insulindependent diabetes (IDDM) and nonAinsulindependent diabetes (NLDDM) (0-34 years at onset) in Benghazi, Libya. Diabet Res Clin Pract 1996; 32: 3: 165-173. Doi: 10.1016/0168-8227(96)01262-4.
  30. Kirpichnikov D., Sowers J.R. Diabetes mellitus and diabetesAassociated vascular disease. Trends Endocrinol Metabol 2001; 12: 5: 225-230. Doi: 10.1016/S1043-2760(01)00391-5.
  31. Kitagawa T., Owada M., Urakami T., Yamauchi K. Increased incidence of nonAinsulin dependent diabetes mellitus among Japanese schoolchildren correlates with an increased intake of animal protein and fat. Clin Pediatr 1998; 37: 2: 111-115.
  32. Laakso M. Lipids in type 2 diabetes. Semin Vasc Med 2002; 2: 1: 59-66.
  33. Landin-Olsson M. Latent autoimmune diabetes in adults. Ann N Y Acad Sci 2002; 958: 112-116. Doi: 10.1111/j.1749-6632.2002.tb02953.x.
  34. Lee S., Bacha F., Gungor N., Arslanian S.A. Waist circumference is an independent predictor of insulin resistance in black and white youths. J Pediatr 2006;148(2):188-94. doi:10.1016/j.jpeds.2005.10.001.
  35. Lewy V., Danadian K., Witchel S.F., Arslanian S. Early metabolic abnormalities in adolescent girls with polycystic ovarian syndrome. J Pediatr 2001; 138: 1: 38-44. doi:10.1067/mpd.2001.109603.
  36. Loder R.T., Aronson D.D., Greenfield M.L. The epidemiology of bilateral slipped capital femoral epiphysis. A study of children in Michigan. J Bone Joint Surg 1993; 75: 8: 1141-1147.
  37. McGrath N.M., Parker G.N., Dawson P. Early presentation of type 2 diabetes mellitus in young New Zealand Maori. Diabet Res Clin Pract 1999; 43: 3: 205-209. Doi: 10.1016/S0168-8227(99)00003-0.
  38. Miller J., Silverstein J., Rosenbloom A.L. Type 2 diabetes in the child and adolescent. In: Endocrinology: Fifth edition. NY: Marcel Dekker 2007; 1: 169-188.
  39. Misra A., Vikram N.K., Arya S., Pandey R.M., Dhingra V., Chatterjee A., Dwivedi M., Sharma R., Luthra K., Guleria R., Talwar K.K. High prevalence of insulin resistance in postpubertal Asian Indian children is associated with adverse truncal body fat patterning, abdominal adiposity and excess body fat. Int J Obes 2004; 28: 1217-1226.
  40. Morales A., Rosenbloom A.L. Death caused by hyperglycemic hyperosmolar state at the onset of type 2 diabetes. J Pediar 2004; 144: 2: 270-273. doi:10.1016/j.jpeds.2003.10.061.
  41. Norman R.J., Dewailly D., Legro R.S., Hickey T.E. Polycystic ovary syndrome. Lancet 2007; 370: 9588: 685-697. doi:10.1016/S0140-6736(07)61345-2.
  42. Pinhasahamiel O., Zeitler P. The global spread of type 2 diabetes mellitus in children and adolescents. J Pediatr 2005; 146: 5: 693-700. doi:10.1016/j.jpeds.2004.12.042.
  43. Pinhasahamiel O., Zeitler P. Acute and chronic complications of type 2 diabetes mellitus in children and adolescents. Lancet 2007; 369: 9575: 1823-1831. doi:10.1016/S0140-6736(07)60821-6.
  44. Plourde G. Impact of obesity on glucose and lipid profiles in adolescents at different age groups in relation to adulthood. BMC Fam Pract 2002; 3: 18. doi:10.1186/1471-2296-3-18.
  45. Poredos P. Endothelial dysfunction and cardiovascular disease. Pathophysiol Haemost Thrombol 2002; 32: 5-6: 274-277. Doi:10.1159/000073580.
  46. Ramachandran A., Snehalatha C., Satyavani K., Sivasankari S., Vijay V. Type 2 diabetes in Asian-Indian urban children. Diabet Care 2003; 26: 4: 1022-1025. doi:10.2337/diacare.26.4.1022.
  47. Reinehr T., Schober E., Wiegand S., Thon A., Holl R. DPV-Wiss Study Group. Beta-cell autoantibodies in children with type 2 diabetes mellitus: subgroup or misclassification? Arch Dis Child 2006; 91: 473-477.
  48. Rosenbloom A.L. Obesity, insulin resistance, beta cell autoimmunity, and the changing clinical epidemiology of childhood diabetes. Diabet Care 2003; 26: 10: 2954-2956. doi:10.2337/diacare.26.10.2954.
  49. Rosenbloom A.L., Joe J.R., Young R.S., Winter W.E. Emerging epidemic of type 2 diabetes in youth. Diabet Care 1999; 22: 2: 345-354. doi: 10.2337/diacare.22.2.345.
  50. Salomaa V.V., Strandberg T.E., Vanhanen H., Naukkarinen V., Sarna S., Miettinen T.A. Glucose tolerance and blood pressure: long-term followup in middle-age men. BMJ 1991; 302: 6775: 493-496.
  51. Sayeed M., Hunsain M., Banu A., Rumi M.A., Azad Khan A.K. Prevalence of diabetes in a suburban population of Bangladesh. Diabet Res Clin Pract 1997; 34: 3: 149-155. Doi: 10.1016/S0168-8227(96)01337-X.
  52. Shalitin S., Abrahami M., Lilos P., Phillip M. Insulin resistance and impaired glucose tolerance in obese children and adolescents referred to a tertiary care center in Israel. Int J Obes 2005; 29: 6: 571-578. doi:10.1038/sj.ijo.0802919.
  53. Smith J.C., Field C., Braden D.S., Gaymes C.H., Kastner J. Coexisting health problems in obese children and adolescents that might require special treatment considerations. Clin Pediatr 1999; 38: 5: 305-307.
  54. Baranowski T., Cooper D.M., Harrell J., Hirst K., Kaufman F.R., Goran M., Resnicow K. STOPP-T2D Prevention Study Group. Presence of diabetes risk factors in a large U.S. eighth-grade cohort. Diabet Care 2006; 29: 2: 212-217. doi:10.2337/diacare.29.02.06.dc05-1037.
  55. Strauss R., Barlow S., Dietz W.H. Prevalence of abnormal serum aminotransferase values in overweight and obese adolescents. J Pediatr 2000; 136: 6: 727-733.
  56. Sugihara S., Sasaki N., Kohno H., Amemiya S., Tanaka T., Matsuura N. Committee for the Medical Treatment of Childhood-Onset Type 2 Diabetes Mellitus, The Japanese Society for Pediatric Endocrinology.Survey of current medical treatments for childhood-onset type 2 diabetes mellitus in Japan. Clin Pediatr Endocrinol 2005; 14: 2: 65-75. doi: 10.1297/cpe.14.65.
  57. Tounian P., Aggoun Y., Dubern B., Varille V., Guy-Grand B., Sidi D., Girardet J.P., Bonnet D. Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: a prospective study. Lancet 2001; 358: 9291: 1400-1404. doi:10.1016/S0140-6736(01)06525-4.
  58. Tresaco B., Bueno G., Moreno L.A., Garagorri J.M., Bueno M. Insulin resistance and impaired glucose tolerance in obese children and adolescents. J Physiol Biochem 2003; 59: 3: 217-224.
  59. Turner R., Stratton I., Horton V., Manley S., Zimmet P., Mackay I.R., Shattock M., Bottazzo G.F., Holman R. UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulinrequirement in type 2 diabetes. UK Prospective Diabetes Study Group. Lancet 1997; 350: 9087: 1288-1293. doi:10.1016/S0140-6736(97)03062-6.
  60. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk ofcomplications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998; 352: 9131: 837-853. doi:10.1016/S0140-6736(98)07019-6.
  61. Umpaichitra V., Banerji M.A., Castells S. Autoantibodies in children with type 2 diabetes mellitus. J Pediatr Endocrinol Metabol 2002; Suppl: 1: 525-530.
  62. Visser M., Bouter L., Mcquillan G.M., Wener M.H., Harris T.B. Low-grade systemic inflammation in overweight children. Pediatrics 2001; 107: 1: E13. doi: 10.1542/peds.107.1.e13.
  63. Wabitsch M., Hauner H., Hertrampf M., Muche R., Hay B., Mayer H., Kratzer W., Debatin K.M., Heinze E. Type II diabetes mellitus and impaired glucose regulation in Caucasian children and adolescents with obesity living in Germany. Int J Obes 2004; 28: 2: 307-313.
  64. Wei J.N., Sung F.C., Li C.Y., Chang C.H., Lin R.S., Lin C.C., Chiang C.C., Chuang L.M. Low birth weight and high birth weight infants are both at an increased risk to have type 2 diabetes among schoolchildren in Taiwan. Diabet Care 2003; 26: 2: 343-348. doi:10.2337/diacare.26.2.343.
  65. Weiss R., Dufour S., Taksali S.E., Tamborlane W.V., Petersen K.F., Bonadonna R.C., Boselli L., Barbetta G., Allen K., Rife F., Savoye M., Dziura J., Sherwin R., Shulman G.I., Caprio S. Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning. Lancet 2003; 362: 9388: 951-957. doi:10.1016/S0140-6736(03)14364-4.
  66. Wiegand S., Maikowski U., Blankenstein O., Biebermann H., Tarnow P., Grüters A. Type 2 diabetes and impaired glucose tolerance in European children and adolescents with obesity - a problem that is no longer restricted to minority groups. Eur J Endocrinol 2004; 151: 2: 199-206. doi: 10.1530/eje.0.1510199.
  67. Wierzbicki A.S., Nimmo L., Feher M.D., Cox A., Foxton J., Lant A.F. Association of angiotensin-converting enzyme DD genotype with hypertension in diabetes. J Hum Hypertens 1995; 9: 8: 671-673.
  68. Winter W., Maclaren N., Riley W.J., Clarke D.W., Kappy M.S., Spillar R.P. Maturity onset diabetes of youth in black Americans. N Engl J Med 1987; 316: 6: 285-291. Doi: 10.1056/NEJM198702053160601.
  69. Writing Group for the SEARCH for Diabetes in Youth Study Group, Dabelea D., Bell R.A., D'Agostino R.B.Jr., Imperatore G., Johansen J.M., Linder B., Liu L.L., Loots B., Marcovina S., Mayer-Davis E.J., Pettitt D.J., Waitzfelder B. Incidence of diabetes in youth in the United States. JAMA 2007; 297: 24: 2716-2724. doi:10.1001/jama.297.24.2716.
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