Anomalous lipoprotein-X in type 2 diabetes mellitus

Ovsepian M.R.; Ébragimzade M.G.; Gabrielian A.B.; Oganesian M.G.; Gevorkian A.A.; Mamikonian A.A.; Boiadzhian A.S.

doi:https://doi.org/

Ovsepian M.R.

Institut molekuliarnoĭ biologii Natsional'noĭ akademii nauk Respubliki Armeniia (NAN RA), Erevan

Ébragimzade M.G.

Institut molekuliarnoĭ biologii Natsional'noĭ akademii nauk Respubliki Armeniia (NAN RA), Erevan

Gabrielian A.B.

Institut molekuliarnoĭ biologii Natsional'noĭ akademii nauk Respubliki Armeniia (NAN RA), Erevan

Oganesian M.G.

Institut molekuliarnoĭ biologii Natsional'noĭ akademii nauk Respubliki Armeniia (NAN RA), Erevan;
Rossiĭsko-Armianskiĭ (Slavianskiĭ) gosudarstvennyĭ universitet, Erevan

Gevorkian A.A.

Meditsinskiĭ tsentr "Armeniia" MZ Respubliki Armeniia, Erevan

Mamikonian A.A.

Meditsinskiĭ tsentr "Armeniia" MZ Respubliki Armeniia, Erevan

Boiadzhian A.S.

Institut molekuliarnoĭ biologii Natsional'noĭ akademii nauk Respubliki Armeniia (NAN RA), Erevan;
Rossiĭsko-Armianskiĭ (Slavianskiĭ) gosudarstvennyĭ universitet, Erevan

Anomalous lipoprotein-X in type 2 diabetes mellitus

Authors:

Ovsepian M.R., Ébragimzade M.G., Gabrielian A.B., Oganesian M.G., Gevorkian A.A., Mamikonian A.A., Boiadzhian A.S.

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Journal: Problems of Endocrinology. 2012;58(4): 18‑21

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To cite this article:

Ovsepian MR, Ébragimzade MG, Gabrielian AB, Oganesian MG, Gevorkian AA, Mamikonian AA, Boiadzhian AS. Anomalous lipoprotein-X in type 2 diabetes mellitus. Problems of Endocrinology. 2012;58(4):18‑21. (In Russ.)

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Abstract:

Type 2 diabetes mellitus (DM2) is the most common form of diabetes characterized by the disturbances of carbohydrate, protein, and lipid metabolism including dyslipidemia and elevation of the low-density lipoprotein (LDLP) levels. Lipoprotein-X (LP-X) represents an anomalous subclass of LDLP a distinctive feature of which is the high content of phospholipids and non-esterified cholesterol coupled with the low level of cholesterol ethers, triglycerides, and proteins. LP-X was detected in the blood of the patients with various diseases of the liver and biliary ducts associated with cholestasis. The results of our previous investigations suggest the presence of LP-X in the blood of the patients with familial Mediterranean fever and ischemic stroke complicated by concomitant diabetes mellitus. The objective of the present work was to elucidate whether LP-X actually occurs in the blood of the patients presenting with type 2 diabetes mellitus. We used the method of polyanionic precipitation of LDLP preliminarily separated by agar gel electrophoresis. The study has demonstrated for the first time the presence of LP-X in the blood of the patients with type 2 diabetes mellitus. Its possible pathogenetic role and mechanisms of LP-X generation in DM2 are discussed.

Keywords:

lipoprotein-X

low-density lipoproteins

type 2 diabetes mellitus

Authors:

Ovsepian M.R.

Institut molekuliarnoĭ biologii Natsional'noĭ akademii nauk Respubliki Armeniia (NAN RA), Erevan

Ébragimzade M.G.

Institut molekuliarnoĭ biologii Natsional'noĭ akademii nauk Respubliki Armeniia (NAN RA), Erevan

Gabrielian A.B.

Institut molekuliarnoĭ biologii Natsional'noĭ akademii nauk Respubliki Armeniia (NAN RA), Erevan

Oganesian M.G.

Institut molekuliarnoĭ biologii Natsional'noĭ akademii nauk Respubliki Armeniia (NAN RA), Erevan;
Rossiĭsko-Armianskiĭ (Slavianskiĭ) gosudarstvennyĭ universitet, Erevan

Gevorkian A.A.

Meditsinskiĭ tsentr "Armeniia" MZ Respubliki Armeniia, Erevan

Mamikonian A.A.

Meditsinskiĭ tsentr "Armeniia" MZ Respubliki Armeniia, Erevan

Boiadzhian A.S.

Institut molekuliarnoĭ biologii Natsional'noĭ akademii nauk Respubliki Armeniia (NAN RA), Erevan;
Rossiĭsko-Armianskiĭ (Slavianskiĭ) gosudarstvennyĭ universitet, Erevan

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