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Kalinnikova A.A.

Nizhegorodskaia gosudarstvennaia meditsinskaia akademiia

Strongin L.G.

Kafedra akusherstva i ginekologii Nizhegorodskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Petrov A.V.

State Research Institute of Highly Pure Biopreparations, Federal Biomedical Agency, St. Petersburg, Russia

Neliubina T.A.

Éndokrinologicheskoe otdelenie MLPU "Gorodskaia bol'nitsa #2" Dzerzhinska

Dynamics of glycemia following subcutaneous administration of Rinsulins NPH and P in comparison with insulins Protaphane and Actrapid at the onset of insulinotherapy in the patients with type 2 diabetes mellitus

Authors:

Kalinnikova A.A., Strongin L.G., Petrov A.V., Neliubina T.A.

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Journal: Problems of Endocrinology. 2011;57(5): 38‑41

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To cite this article:

Kalinnikova AA, Strongin LG, Petrov AV, Neliubina TA. Dynamics of glycemia following subcutaneous administration of Rinsulins NPH and P in comparison with insulins Protaphane and Actrapid at the onset of insulinotherapy in the patients with type 2 diabetes mellitus. Problems of Endocrinology. 2011;57(5):38‑41. (In Russ.)

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The introduction of novel insulin analogs into medical practice requires clinical data confirming their comparability with the currently used preparations. The objective of present work was to compare the hypoglycemic action of a single injection of Rinsulins NPH and P (Natsional'nye tekhnologii, Russia) on the one hand and insulins Protaphane and Actrapid (Novo Nordisk, Denmark) on the other hand in 18 insulin-naïve patients with type 2 diabetes mellitus treated in the hospital environment. The tested analogs were randomly administered to the patients within 4 days after hospitalization. Blood glucose levels were measured ten times each day. No significant difference in the dynamics of glycemia between the patients treated with either group of preparations was documented.

Keywords:

type 2 diabetes mellitus
insulin therapy
glycemia
efficacy

Authors:

Kalinnikova A.A.

Nizhegorodskaia gosudarstvennaia meditsinskaia akademiia

Strongin L.G.

Kafedra akusherstva i ginekologii Nizhegorodskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Petrov A.V.

State Research Institute of Highly Pure Biopreparations, Federal Biomedical Agency, St. Petersburg, Russia

Neliubina T.A.

Éndokrinologicheskoe otdelenie MLPU "Gorodskaia bol'nitsa #2" Dzerzhinska

List of references:

  1. Ametov A.S. Sovremennye metody terapii sakharnogo diabeta 2-go tipa. RMZh 2008; 16: 4: 170-178.
  2. Ametov A.S., Karpova E.V. Otsenka effektivnosti insulinoterapii u patsientov s sakharnym diabetom 2-go tipa: ot teorii k praktike. RMZh 2008; 16: 9: 1000-1006.
  3. Balabolkin M.I., Klebanova E.M. Insulinoterapiya sakharnogo diabeta na sovremennom etape. Lechashchii vrach 2006; №2.
  4. The Action to Control Cardiovascular Risk in Diabetes Study Group. Effects of Intensive Glucose Lowering in Type 2 Diabetes. N Engl J Med 2008; 358: 2545-2559.
  5. The ADVANCE Collaborative Group. Intensive Blood Glucose Control and Vascular Outcomes in Patients with Type 2 Diabetes. N Engl J Med 2008; 358: 2560-2572.
  6. Hompesch M., Troupin B., Heise T., Elbroend B., Endahl L., Haahr H., Heinemann L. Time-action profile of insulin detemir and NPH insulin in patients with type 2 diabetes from different ethnic groups. Diabetes Obes Metab 2006; 8: 5: 568-573.

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