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Korableva N.P.

St. Petersburg State Pediatric Medical University

Romanenkov N.S.

St. Petersburg State Pediatric Medical University

Kremlev D.I.

St. Petersburg State Pediatric Medical University

Kosulin A.V.

St. Petersburg State Pediatric Medical University

Nekrasov A.A.

St. Petersburg State Pediatric Medical University

Kovalenko A.P.

St. Petersburg State Pediatric Medical University

Miroshnichenko M.S.

St. Petersburg State Pediatric Medical University

Arbekov P.V.

St. Petersburg State Pediatric Medical University

Prevention of pathological skin scars (experimental study)

Authors:

Korableva N.P., Romanenkov N.S., Kremlev D.I., Kosulin A.V., Nekrasov A.A., Kovalenko A.P., Miroshnichenko M.S., Arbekov P.V.

More about the authors

Journal: Plastic Surgery and Aesthetic Medicine. 2025;(1): 32‑38

DOI: 10.17116/plast.hirurgia202501132

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Table of contents

PREVENTION OF PATHOLOGICAL SKIN SCARS (EXPERIMENTAL STUDY)
PREVENTION OF PATHOLOGICAL SKIN SCARS (EXPERIMENTAL STUDY)

To cite this article:

Korableva NP, Romanenkov NS, Kremlev DI, et al. . Prevention of pathological skin scars (experimental study). Plastic Surgery and Aesthetic Medicine. 2025;(1):32‑38. (In Russ., In Engl.)
https://doi.org/10.17116/plast.hirurgia202501132

Подписка 2025-2 (Plastic Surgery and Aesthetic Medicine)
 
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OBJECTIVE

To estimate the efficacy of botulinum toxin type A in prevention of hypertrophic and keloid skin scars.

MATERIAL AND METHODS

Experimental animals were 3 rabbits Soviet Chinchilla breed. Five ellipsoid wounds were inflicted and then sutured on the outer surface of each ear. The right ear was control, and the left ear was experimental. After 7 days, 2 units of botulinum toxin type A were injected into the scars on the experimental ear. At the control points (14, 28, 42 days), scars were assessed visually. Biopsy was performed with assessment of fibroblasts and myofibroblasts.

RESULTS

Visual assessment of scars in the control group revealed hypertrophic scars in 4 out of 15 cases. In the experimental group, no hypertrophic scars were detected. In 42 days after botulinum toxin type A injection, there were fewer fibroblasts in the experimental group (p=0.01). The number of myofibroblasts in scar tissue of experimental animals in 14, 28 and 42 days after botulinum toxin type A injection was 2 times lower than in the control group (p=0.000003).

CONCLUSION

Botulinum toxin type A is effective for prevention of hypertrophic and keloid scars due to its effect on fibroblasts and myofibroblasts.

Keywords:

botulinum toxin type A
scar correction
hypertrophic scars
keloid scars
prevention of pathological scars

Authors:

Korableva N.P.

St. Petersburg State Pediatric Medical University

Romanenkov N.S.

St. Petersburg State Pediatric Medical University

Kremlev D.I.

St. Petersburg State Pediatric Medical University

Kosulin A.V.

St. Petersburg State Pediatric Medical University

Nekrasov A.A.

St. Petersburg State Pediatric Medical University

Kovalenko A.P.

St. Petersburg State Pediatric Medical University

Miroshnichenko M.S.

St. Petersburg State Pediatric Medical University

Arbekov P.V.

St. Petersburg State Pediatric Medical University

Received:

18.06.2024

Accepted:

12.07.2024

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