The relevance of aesthetic treatments with dermal fillers, botulinum toxin, energy-based devices, and cometic threads to improve the appearance of the patient and, as a result, the quality of life, is confirmed by several studies in recent years. Protocols for their use, considering the multi-level impact in different areas of the face, are becoming increasingly widespread and in demand in clinical practice. To date, there is insufficient data on the algorithm for choosing a treatment strategy in combined programs from the point of view of the efficacy and safety of procedures for patients of various types of aging. Analysis of published studies and recommendations of the authors, based on personal experience, will enable wider use of combined programs with a good profile of efficacy and safety. A combination of fillers and thread lifting is possible in one treatment session, but the methods should be used in different areas of the face. To make the combined effect safer, it is advisable to separate the time of these procedures. It is not recommended to treat the upper face with botulinum toxin and thread lifting within one session due to the anesthesia that accompanies thread implantation. When planning combined treatment protocol, the period of rehabilitation after implantation of the threads with the possible prescription of antibiotic therapy should be taken into account. The sequence or synergy of the methods is determined individually, considering aesthetic indications, anatomical and age characteristics, and individual preferences of the physician and the patient.