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Koen I.A.

Pirogov Russian National Research Medical University

Ustyugov A.Yu.

The Russian National Research Medical University named after N.I. Pirogov

Manturova N.E.

Pirogov Russian National Research Medical University;
Institute of Plastic Surgery and Cosmetology

Influence of the patient’s somatic factors on the properties of lipoaspirate

Authors:

Koen I.A., Ustyugov A.Yu., Manturova N.E.

More about the authors

Journal: Plastic Surgery and Aesthetic Medicine. 2021;(3): 102‑108

DOI: 10.17116/plast.hirurgia2021031102

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Table of contents

INFLUENCE OF THE PATIENT’S SOMATIC FACTORS ON THE PROPERTIES OF LIPOASPIRATE
INFLUENCE OF THE PATIENT’S SOMATIC FACTORS ON THE PROPERTIES OF LIPOASPIRATE

To cite this article:

Koen IA, Ustyugov AYu, Manturova NE. Influence of the patient’s somatic factors on the properties of lipoaspirate. Plastic Surgery and Aesthetic Medicine. 2021;(3):102‑108. (In Russ., In Engl.)
https://doi.org/10.17116/plast.hirurgia2021031102

 
Подписка 2025-2 (Plastic Surgery and Aesthetic Medicine)
 
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Adipose tissue transplantation has been widely used for several decades. However, one of the unsolved problems is still unpredictable resorption of adipose tissue after transplantation. Technique and conditions of lipoaspiration procedure are not the only factors affecting the results of adipose tissue engraftment following autologous transplantation. Other predictors are age, gender, body mass index, menopausal status, estrogen level, choice of donor area for transplantation, chronic diseases, such as diabetes mellitus, uptake of cytostatics, etc. To date, there are various contradictory data indicating possible influence of individual patient factors on proliferative activity, viability of adipocytes and adipose derived stem cells during liposuction for subsequent autotransplantation of adipose tissue. The purpose of this article is critical evaluation of these data.

Keywords:

lipoaspirate
adipose derived stem cells
adipocytes
donor area

Authors:

Koen I.A.

Pirogov Russian National Research Medical University

Ustyugov A.Yu.

The Russian National Research Medical University named after N.I. Pirogov

Manturova N.E.

Pirogov Russian National Research Medical University;
Institute of Plastic Surgery and Cosmetology

Received:

16.03.2021

Accepted:

22.04.2021

List of references:

  1. Yoshimura K, Suga H, Eto H. Adipose-derived stem/progenitor cells: roles in adipose tissue remodeling and potential use for soft tissue augmentation. Regen Med. 2009;4(2):265-273.  https://doi.org/10.2217/17460751.4.2.265
  2. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003;112(12):1796-1808. https://doi.org/10.1172/JCI200319246
  3. Xu H, Barnes GT, Yang Q, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest. 2003;112(12):1821-1830. https://doi.org/10.1172/JCI200319451
  4. Orlova YuM, Ustyugov AYu, Zorina AI, Zorin VL, Pospelov AL. Kletochnye preparaty iz zhirovoj tkani. Plastic Surgery and Aesthetic Medicine. 2019;3:62-69.  https://doi.org/10.17116/plast.hirurgia201903162
  5. Silina EV, Manturova NE, Litvitskiy PF, Stupin VA. Comparative analysis of the effectiveness of some biological injected wound healing stimulators and criteria for its evaluation. Drug Des Devel Ther. 2020;14:4869-4883. https://doi.org/10.2147/DDDT.S277047
  6. Silina E, Manturova N, Stupin V. Mesenchymal stem cells application in wound tissue healing in old animals. Stem Cells Cloning Adv Appl. 2020; 13:103-116.  https://doi.org/10.2147/SCCAA.S267967
  7. Laloze J, Varin A, Gilhodes J, et al. Cell-Assisted Lipotransfer: Friend or Foe in Fat Grafting? Systematic Review and Meta-Analysis. 2018;12(2):1237-1250. First published: 18 July 2017. https://doi.org/10.1002/term.2524
  8. Strong AL, Cederna PS, Rubin JP, Coleman SR, Levi B. The Current state of fat grafting: A review of harvesting, processing, and injection techniques. Plast Reconstr Surg. 2015;136(4):897-912.  https://doi.org/10.1097/PRS.0000000000001590
  9. Geissler PJ, Davis K, Roostaeian J, Unger J, Huang J, Rohrich RJ. Improving fat transfer viability: The role of aging, body mass index, and harvest site. Plast Reconstr Surg. 2014;134(2):227-232.  https://doi.org/10.1097/PRS.0000000000000398
  10. Aust L, Devlin B, Foster SJ, et al. Yield of human adipose-derived adult stem cells from liposuction aspirates. Cytotherapy. 2004;6(1):7-14.  https://doi.org/10.1080/14653240310004539
  11. Faustini M, Bucco M, Chlapanidas T, et al. Nonexpanded mesenchymal stem cells for regenerative medicine: Yield in stromal vascular fraction from adipose tissues. Tissue Eng Part C Methods. 2010;16(6):1515-1521. https://doi.org/10.1089/ten.tec.2010.0214
  12. Harris LJ, Zhang P, Abdollahi H, et al. Availability of adipose-derived stem cells in patients undergoing vascular surgical procedures. J Surg Res. 2010; 163(2):105-112.  https://doi.org/10.1016/j.jss.2010.04.025
  13. Mojallal A, Lequeux C, Shipkov C, et al. Influence of age and body mass index on the yield and proliferation capacity of Adipose-derived stem cells. Aesthetic Plast Surg. 2011;35(6):1097-1105. https://doi.org/10.1007/s00266-011-9743-7
  14. Padoin AV, Braga-Silva J, Martins P, et al. Sources of processed lipoaspirate cells: Influence of donor site on cell concentration. Plast Reconstr Surg. 2008;122(2):614-618.  https://doi.org/10.1097/PRS.0b013e31817d5476
  15. Schipper BM, Marra KG, Zhang W, Donnenberg AD, Rubin JP. Regional anatomic and age effects on cell function of human adipose-derived stem cells. Ann Plast Surg. 2008;60(5):538-544.  https://doi.org/10.1097/SAP.0b013e3181723bbe
  16. Van Harmelen V, Skurk T, Röhrig K, et al. Effect of BMI and age on adipose tissue cellularity and differentiation capacity in women. Int J Obes. 2003;27(8):889-895.  https://doi.org/10.1038/sj.ijo.0802314
  17. Yoshimura K, Shigeura T, Matsumoto D, et al. Characterization of freshly isolated and cultured cells derived from the fatty and fluid portions of liposuction aspirates. J Cell Physiol. 2006;208(1):64-76.  https://doi.org/10.1002/jcp.20636
  18. Yu G, Wu X, Dietrich MA, et al. Yield and characterization of subcutaneous human adipose-derived stem cells by flow cytometric and adipogenic mRNA analyzes. Cytotherapy. 2010;12(4):538-546.  https://doi.org/10.3109/14653241003649528
  19. Kawagishi-Hotta M, Hasegawa S, Igarashi T, et al. Enhancement of individual differences in proliferation and differentiation potentials of aged human adipose-derived stem cells. Regen Ther. 2017;6:29-40.  https://doi.org/10.1016/j.reth.2016.12.004
  20. Alt EU, Senst C, Murthy SN, et al. Aging alters tissue resident mesenchymal stem cell properties. Stem Cell Res. 2012;8(2):215-225.  https://doi.org/10.1016/j.scr.2011.11.002
  21. Madonna R, Renna FV, Cellini C, et al. Age-dependent impairment of number and angiogenic potential of adipose tissue-derived progenitor cells. Eur J Clin Invest. 2011;41(2):126-133.  https://doi.org/10.1111/j.1365-2362.2010.02384.x
  22. Choudhery MS, Badowski M, Muise A, Pierce J, Harris DT. Donor age negatively impacts adipose tissue-derived mesenchymal stem cell expansion and differentiation. J Transl Med. 2014;12(1):1-14.  https://doi.org/10.1186/1479-5876-12-8
  23. Hauner H, Entenmann G, Wabitsch M, et al. Promoting effect of glucocorticoids on the differentiation of human adipocyte precursor cells cultured in a chemically defined medium. J Clin Invest. 1989;84(5):1663-1670. https://doi.org/10.1172/JCI114345
  24. Girolamo L De, Lopa S, Arrigoni E, Sartori MF, Baruffaldi Preis FW, Brini AT. Human adipose-derived stem cells isolated from young and elderly women: Their differentiation potential and scaffold interaction during in vitro osteoblastic differentiation. Cytotherapy. 2009;11(6):793-803.  https://doi.org/10.3109/14653240903079393
  25. Zhu M, Kohan E, Bradley J, Hedrick M, Benhaim P, Zuk P. The effect of age on osteogenic, adipogenic and proliferative potential of female adipose-derived stem cells. J Tissue Eng Regen Med. 2009;3(4):290-301.  https://doi.org/10.1002/term.165
  26. Erickson GR, Gimble JM, Franklin DM, Rice HE, Awad H, Guilak F. Chondrogenic potential of adipose tissue-derived stromal cells in vitro and in vivo. Biochem Biophys Res Commun. 2002;290(2):763-769.  https://doi.org/10.1006/bbrc.2001.6270
  27. Deslex S, Negrel R, Ailhaud G. Development of a chemically defined serum-free medium for differentiation of rat adipose precursor cells. Exp Cell Res. 1987;168(1):15-30.  https://doi.org/10.1016/0014-4827(87)90412-5
  28. Djian P, Roncari DAK, Hollenberg CH. Influence of anatomic site and age on the replication and differentiation of rat adipocyte precursors in culture. J Clin Invest. 1983;72(4):1200-1208. https://doi.org/10.1172/JCI111075
  29. Sharpless NE, DePinho RA. How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol. 2007;8(9):703-713.  https://doi.org/10.1038/nrm2241
  30. Pandey AC, Semon JA, Kaushal D, et al. MicroRNA profiling reveals age-dependent differential expression of nuclear factor B and mitogen-activated protein kinase in adipose and bone marrow-derived human mesenchymal stem cells. Stem Cell Res Ther. 2011;2(6):1-18.  https://doi.org/10.1186/scrt90
  31. Zhao Y, Waldman SD, Flynn LE. The effect of serial passaging on the proliferation and differentiation of bovine adipose-derived stem cells. Cells Tissues Organs. 2012;195(5):414-427.  https://doi.org/10.1159/000329254
  32. Kornicka K, Marycz K, Tomaszewski KA, Marędziak M, Smieszek A. The Effect of Age on Osteogenic and Adipogenic Differentiation Potential of Human Adipose Derived Stromal Stem Cells (hASCs) and the Impact of Stress Factors in the Course of the Differentiation Process. Oxid Med Cell Longev. 2015;2015. https://doi.org/10.1155/2015/309169
  33. Van Harmelen V, Röhrig K, Hauner H. Comparison of Proliferation and Differentiation Capacity of Human Adipocyte Precursor Cells from the Omental and Subcutaneous Adipose Tissue Depot of Obese Subjects. Metabolism. 2004;53(5):632-637.  https://doi.org/10.1016/j.metabol.2003.11.012
  34. Aksu AE, Rubin JP, Dudas JR, Marra KG. Role of gender and anatomical region on induction of osteogenic differentiation of human adipose-derived stem cells. Ann Plast Surg. 2008;60(3):306-322.  https://doi.org/10.1097/SAP.0b013e3180621ff0
  35. Rodriguez-Cuenca S, Monjo M, Proenza AM, Roca P. Depot differences in steroid receptor expression in adipose tissue: Possible role of the local steroid milieu. Am J Physiol Endocrinol Metab. 2005;288(1):200-207.  https://doi.org/10.1152/ajpendo.00270.2004
  36. Brown LM, Gent L, Davis K, Clegg DJ. Metabolic impact of sex hormones on obesity. Brain Res. 2010;1350:77-85.  https://doi.org/10.1016/j.brainres.2010.04.056
  37. Luo S, Hao L, Li X, et al. Adipose tissue-derived stem cells treated with estradiol enhance survival of autologous fat transplants. Tohoku J Exp Med. 2013;231(2):101-110.  https://doi.org/10.1620/tjem.231.101
  38. Zhou J, Lu P, Ren H, et al. 17Β-Estradiol Protects Human Eyelid-Derived Adipose Stem Cells Against Cytotoxicity and Increases Transplanted Cell Survival in Spinal Cord Injury. J Cell Mol Med. 2014;18(2):326-343.  https://doi.org/10.1111/jcmm.12191
  39. Bills JD, Derderian C, Barker J, Lowe A, Lavery LA, Davis KE. The role of estrogen in the modulation of autologous fat graft outcomes. Plast Reconstr Surg. 2015;135(1):103e-113e. https://doi.org/10.1097/PRS.0000000000000792
  40. Frazier TP, Gimble JM, Devay JW, Tucker HA, Chiu ES, Rowan BG. Body mass index affects proliferation and osteogenic differentiation of human subcutaneous adipose tissue-derived stem cells. BMC Cell Biol. 2013;14:34.  https://doi.org/10.1186/1471-2121-14-34
  41. Isakson P, Hammarstedt A, Gustafson B, Smith U. Impaired preadipocyte differentiation in human abdominal obesity: Role of Wnt, tumor necrosis factor-α, and inflammation. Diabetes. 2009;58(7):1550-1557. https://doi.org/10.2337/db08-1770
  42. Pérez LM, Bernal A, San Martín N, Gálvez BG. Obese-derived ASCs show impaired migration and angiogenesis properties. Arch Physiol Biochem. 2013; 119(5):195-201.  https://doi.org/10.3109/13813455.2013.784339
  43. Pérez LM, Bernal A, De Lucas B, et al. Altered metabolic and stemness capacity of adipose tissue-derived stem cells from obese mouse and human. PLoS One. 2015;10(4):1-22.  https://doi.org/10.1371/journal.pone.0123397
  44. Roldan M, Macias‐Gonzalez M, Garcia R, Tinahones FJ, Martin M. Obesity short‐circuits stemness gene network in human adipose multipotent stem cells. FASEB J. 2011;25(12):4111-4126. https://doi.org/10.1096/fj.10-171439
  45. Ding DC, Chou HL, Hung WT, Liu HW, Chu TY. Human adipose-derived stem cells cultured in keratinocyte serum free medium: Donor’s age does not affect the proliferation and differentiation capacities. J Biomed Sci. 2013; 20(1):1-11.  https://doi.org/10.1186/1423-0127-20-59
  46. Jung JA, Kim YW, Cheon YW, Kang SR. Effects of the diabetic condition on grafted fat survival: An experimental study using streptozotocin-induced diabetic rats. Arch Plast Surg. 2014;41(3):241-247.  https://doi.org/10.5999/aps.2014.41.3.241
  47. West CC, Hardy WR, Murray IR, et al. Prospective purification of perivascular presumptive mesenchymal stem cells from human adipose tissue: Process optimization and cell population metrics across a large cohort of diverse demographics. Stem Cell Res Ther. 2016;7(1):1-12.  https://doi.org/10.1186/s13287-016-0302-7
  48. Morin CL, Pagliassotti MJ, Windmiller D, Eckel RH. Adipose tissue-derived tumor necrosis factor-α activity is elevated in older rats. Journals Gerontol Ser A Biol Sci Med Sci. 1997;52(4):190-195.  https://doi.org/10.1093/gerona/52A.4.B190
  49. Faust IM, Johnson PR, Stern JS, Hirsch J. Diet-induced adipocyte number increase in adult rats: A new model of obesity. Am J Physiol Endocrinol Metab Gastrointest Physiol. 1978;235(3):279-286.  https://doi.org/10.1152/ajpendo.1978.235.3.e279
  50. Hirsch J, Batchelor B. Adipose tissue cellularity in human obesity. Clin Endocrinol Metab. 1976;5(2):299-311.  https://doi.org/10.1016/S0300-595X(76)80023-0
  51. Van Tienen FHJ, Van Der Kallen CJH, Lindsey PJ, Wanders RJ, Van Greevenbroek MM, Smeets HJM. Preadipocytes of type 2 diabetes subjects display an intrinsic gene expression profile of decreased differentiation capacity. Int J Obes. 2011;35(9):1154-1164. https://doi.org/10.1038/ijo.2010.275
  52. Ferrer-Lorente R, Bejar MT, Tous M, Vilahur G, Badimon L. Systems biology approach to identify alterations in the stem cell reservoir of subcutaneous adipose tissue in a rat model of diabetes: Effects on differentiation potential and function. Diabetologia. 2014;57(1):246-256.  https://doi.org/10.1007/s00125-013-3081-z
  53. Minamino T, Orimo M, Shimizu I, et al. A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med. 2009;15(9):1082-1087. https://doi.org/10.1038/nm.2014
  54. Shimizu I, Yoshida Y, Suda M, Minamino T. DNA damage response and metabolic disease. Cell Metab. 2014;20(6):967-977.  https://doi.org/10.1016/j.cmet.2014.10.008
  55. Poglio S, Galvani S, Bour S, et al. Adipose tissue sensitivity to radiation exposure. Am J Pathol. 2009;174(1):44-53.  https://doi.org/10.2353/ajpath.2009.080505
  56. Tsuji W, Schnider JT, McLaughlin MM, et al. Effects of immunosuppressive drugs influence on viability and susceptibility of adipose and bone marrow-derived mesenchymal stem cells. Front Immunol. 2015;6(MAR):1-8.  https://doi.org/10.3389/fimmu.2015.00131
  57. Pike S, Zhang P, Wei Z, et al. In vitro effects of tamoxifen on adipose-derived stem cells. Wound Repair Regen. 2015;23(5):728-736.  https://doi.org/10.1111/wrr.12322
  58. Liang W, Xia H, Li J, Zhao RC. Human adipose tissue derived mesenchymal stem cells are resistant to several chemotherapeutic agents. Cytotechnology. 2011;63(5):523-530.  https://doi.org/10.1007/s10616-011-9374-5
  59. Shukla L, Morrison WA, Shayan R. Adipose-Derived Stem Cells in Radiotherapy Injury: A New Frontier. Front Surg. 2015;2(January):10-13.  https://doi.org/10.3389/fsurg.2015.00001
  60. Eto H, Kato H, Suga H, et al. The fate of adipocytes after nonvascularized fat grafting: Evidence of early death and replacement of adipocytes. Plast Reconstr Surg. 2012;129(5):1081-1092. https://doi.org/10.1097/PRS.0b013e31824a2b19
  61. Panettiere P, Marchetti L, Accorsi D. The serial free fat transfer in irradiated prosthetic breast reconstructions. Aesthetic Plast Surg. 2009;33(5):695-700.  https://doi.org/10.1007/s00266-009-9366-4
  62. Rigotti G, Marchi A, Galiè M, et al. Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: A healing process mediated by adipose-derived adult stem cells. Plast Reconstr Surg. 2007;119(5):1409-1422. https://doi.org/10.1097/01.prs.0000256047.47909.71
  63. Cushman M, Costantino JP, Bovill EG, et al. Effect of tamoxifen on venous thrombosis risk factors in women without cancer: The Breast Cancer Prevention Trial. Br J Haematol. 2003;120(1):109-116.  https://doi.org/10.1046/j.1365-2141.2003.03976.x
  64. Durán H, Cárdenas-Camarena L, Bayter-Marin JE, Ramos-Gallardo G, Robles-Cervantes JA. Microscopic and Macroscopic Fat Embolism: Solving the Puzzle with Case Reports. Plast Reconstr Surg. 2018;142(4):569-577.  https://doi.org/10.1097/PRS.0000000000004810
  65. Small K, Choi M, Petruolo O, Lee C, Karp N. Is there an ideal donor site of fat for secondary breast reconstruction? Aesthetic Surg J. 2014;34(4):545-550.  https://doi.org/10.1177/1090820X14526751
  66. Lim AA, Fan K, Allam KA, et al. Autologous fat transplantation in the craniofacial patient: The UCLA experience. J Craniofac Surg. 2012;23(4):1061-1066. https://doi.org/10.1097/SCS.0b013e31824e695b
  67. Li K, Gao J, Zhang Z, et al. Selection of donor site for fat grafting and cell isolation. Aesthetic Plast Surg. 2013;37(1):153-158.  https://doi.org/10.1007/s00266-012-9991-1
  68. Jurgens WJFM, Oedayrajsingh-Varma MJ, Helder MN, et al. Effect of tissue-harvesting site on yield of stem cells derived from adipose tissue: Implications for cell-based therapies. Cell Tissue Res. 2008;332(3):415-426.  https://doi.org/10.1007/s00441-007-0555-7
  69. Tsekouras A, Mantas D, Tsilimigras DI, Moris D, Kontos M, Zografos GC. Comparison of the viability and yield of adipose-derived stem cells (ASCs) from different donor areas. In Vivo (Brooklyn). 2017;31(6):1229-1234. https://doi.org/10.21873/invivo.11196
  70. Travnickova M, Pajorova J, Zarubova J, Krocilova N, Molitor M, Bacakova L. The Influence of Negative Pressure and of the Harvesting Site on the Characteristics of Human Adipose Tissue-Derived Stromal Cells from Lipoaspirates. Stem Cells Int. 2020;2020:1016231. https://doi.org/10.1155/2020/1016231
  71. Karastergiou K, Fried SK, Xie H, et al. Distinct developmental signatures of human abdominal and gluteal subcutaneous adipose tissue depots. J Clin Endocrinol Metab. 2013;98(1):362-371.  https://doi.org/10.1210/jc.2012-2953
  72. Rohrich RJ, Sorokin ES, Brown SA. In search of improved fat transfer viability: A quantitative analysis of the role of centrifugation and harvest site. Plast Reconstr Surg. 2004;113(1):391-395.  https://doi.org/10.1097/01.PRS.0000097293.56504.00
  73. Ullmann Y, Shoshani O, Fodor A, et al. Searching for the favorable donor site for fat injection: In vivo study using the nude mice model. Dermatologic Surg. 2005;31(10):1304-1307. https://doi.org/10.1097/00042728-200510000-00007

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