Features of regeneration of the rat remnant liver in the early periods after its maximum permissible resection

Khramykh T.P.; Ermolaev P.A.; Barskaya L.O.

doi:https://doi.org/10.17116/operhirurg201820319

Khramykh T.P.

Omsk State Medical University, Ministry of Health of Russia, Omsk, Russia

Ermolaev P.A.

Regional Clinical Hospital, Omsk, Russia

Barskaya L.O.

Omsk State Medical University, Ministry of Health of Russia, Omsk, Russia

Features of regeneration of the rat remnant liver in the early periods after its maximum permissible resection

Authors:

Khramykh T.P., Ermolaev P.A., Barskaya L.O.

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Journal: Russian Journal of Operative Surgery and Clinical Anatomy. 2018;2(3): 9‑13

DOI: 10.17116/operhirurg201820319

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To cite this article:

Khramykh TP, Ermolaev PA, Barskaya LO. Features of regeneration of the rat remnant liver in the early periods after its maximum permissible resection. Russian Journal of Operative Surgery and Clinical Anatomy. 2018;2(3):9‑13. (In Russ.)
https://doi.org/10.17116/operhirurg201820319

Подписка 2026 Оперативная хирургия и клиническая анатомия (Пироговский научный журнал) (Russian Journal of Operative Surgery and Clinical Anatomy)

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Abstract:

Objective. To experimentally reveal the features of regeneration of the rat remnant liver in the early periods after its maximum permissible resection. Material and methods. Atypical 80% liver resection using the original procedure was performed in 60 outbred albino male adult rats. After 6 and 12 hours, 1, 3 and 7 days after surgery, the liver remnants were taken for histological analysis and their sections were stained with hematoxylin and eosin. Results. The leading morphological signs were found to be acute parenchymal dyscirculatory disorders at 6 and 12 hours postresection, hepatocyte dystrophy with some necrotic foci at 1 and 3 days, and hepatocyte regenerative changes as hypertrophy at 7 days. Conclusion. The findings are indicative of the regenerative capabilities of the adult rat liver after its maximum permissible resection as parenchymal hypertrophy, the signs of which were detected on the 7th postoperative day.

Keywords:

liver resection

liver regeneration

rats

Authors:

Khramykh T.P.

Omsk State Medical University, Ministry of Health of Russia, Omsk, Russia

Ermolaev P.A.

Regional Clinical Hospital, Omsk, Russia

Barskaya L.O.

Omsk State Medical University, Ministry of Health of Russia, Omsk, Russia

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