Objective. To conduct preclinical testing of the mandibular exoskeleton using cadaver material to justify its application in patients with mandibular fractures and posttraumatic defects. Materials and methods. The mandibular exoskeleton of original design (priority application №2017125716 dated July 14, 2017) was developed. Fracture and mechanical loading were experimentally modelled using 10 native human mandibular anatomical specimens. The surgical technique was modelled on 3 human male cadavers, by observing all ethical principles. Results. The mandibular exoskeleton allows anatomically precise reposition, rigid, stable fixation, and dosed compression and distraction of mandibular fragments. The low-traumatic surgical technique and preservation of mandibular movements give reason to expect the acceleration of reparative osteogenesis processes. Conclusion. The efficiency of using the mandible exoskeleton requires further evaluation in clinical trials in patients with mandibular fractures and post-traumatic defects.