OBJECTIVE
To investigate the diagnostic value of transrectal ultrasound (TRUS), multiparametric magnetic resonance imaging (mpMRI), total prostate-specific antigen (tPSA), and prostate-specific antigen density (PSAD) in the detection of localized and locally advanced prostate cancer (PC).
Subjects and methods. To estimate the information value of methods for diagnosing PC, 44 patients aged 46 to 81 years (65.73±8.36 years) were examined retrospectively in 2019 and 2020. Patients were selected on the basis of the results of mpMRI, TRUS, and tPSA performed no more than 3 months before TRUS-guided multifocal prostate biopsy, followed by morphological and histochemical studies. Because of the insufficient information value of TRUS in determining distant processes in PC, this study will carry out a statistical analysis only for localized and locally advanced neoplasms.
RESULTS
The sensitivity, specificity, and positive predictive value, negative predictive value, and accuracy of TRUS and mpMRI were 90, 50, 34.6, 94.4, and 63.6% (p=0.024; f=0.031) and 77.8, 53.8, 53.8, 77.8, and 63.6% (p=0.036; f=0.061), respectively. There was a direct, statistically significant moderate correlation (rs=0.540) for tPSA and morphological diagnosis in the age group of 71-81 years (n=14; p=0.046). There was a direct, statistically significant moderate correlation between TRUS, mpMRI, and morphological diagnosis (rs=0.351) (n=44; p=0.019) and rs=0.373 (n=44; p=0.013), respectively. Statistically significant results could not be obtained for PSAD.
CONCLUSION
The findings allow the authors recommend using tPSA, TRUS, and mpMRI to diagnose localized and locally advanced PC.